Home | Links | Contact Us | More About Intellectual Property | Bookmark

Search patents:

Home

Gene Therapy

CDNA-sequences-of-human-bone-matrix-proteins

Antisense inhibition of rank expression

OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly ...

Antisense inhibition of protein kinase C-theta expression

OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly ...

Antisense oligonucleotide modulation of human mdm2 expression

OF THE INVENTION Tumors often result from genetic changes in cellular regulatory genes. Among the ...

Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection

The term "alkyl" as used herein means straight and branched carbon chains of one to twenty carbons,...

Antibacterial agents comprising conjugates of glycopeptides and peptidic membrane associating elements

What is claimed is: 1. An antibacterial compound of formula V-L-W-X; wherein: V is a glycopeptide ...

System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment

In accordance with the above, a primary purpose of Applicants' claimed invention is to provide ...

Recombinant allergenic proteins from ragweed pollen

The present invention relates to allergenic proteins or peptides from ragweed, DNAs encoding all or ...

Nucleic acids encoding allergenic proteins from ragweed

The present invention relates to allergenic proteins or peptides from ragweed, DNAs encoding all or ...

Lactobacilli harboring aggregation gene as a vaccine delivery vehicle

OF THE INVENTION As used herein and in the claims, the term "animal" means mammals and avians, ...

Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria

What is claimed is: 1. An isolated and purified DNA molecule encoding a hybrid protein, said hybrid ...

CDNA sequences of human bone matrix proteins

Details

Inventors: Termine, John D.; Young, Marian F.; Fisher, Larry W.; Robey, Pamela G.;
Assignee: The United States of Americas as represented by the Secretary of Health (Washington, DC)
Primary Examiner: Parr; Margaret
Assistant Examiner: Sisson; Bradley L.
Attorney, Agent or Firm: Townsend and Townsend Khourie and Crew

Amino acid and cDNA sequences of a plurality of human bone matrix proteins and their uses have been described.

DETAILED DESCRIPTION It is, therefore, an object of the present invention to provide specific cDNA and deduced protein sequences which are diagnostic of such human diseases as osteoporosis, osteo/rheumatold arthritis, Paget's disease, atherosclerosis, periodontal disease and the like.
It is another object of the present invention to provide novel probes (sense and anti-sense RNA and DNA derived from the cDNA sequence), antibodies and bioassays for monitoring the level and distribution of certain human bone matrix proteins in the human body fluids or tissues.
Other objects and advantages will become evident from the following detailed description of the invention.

Related patents

	Antisense inhibition of PEPCK-mitochondrial expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...
	Methods of modulating tumor necrosis factor .alpha.-induced expression of cell adhesion molecules OF THE INVENTION The present invention employs specific inhibitors of Ha-ras, c-raf and JNK2, members of the TNF-.alpha. signaling pathway, to modulate cell adhesion ...
	Antisense modulation of telomeric repeat binding factor 1 expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...
	Antisense modulation of interleukin-5 signal transduction OF THE INVENTION The present invention comprehends antisense compounds capable of modulating IL-5 signal transduction, preferably by modulating expression of IL-5 or IL-...
	Antisense modulation of P38 mitogen activated protein kinase expression OF THE INVENTION p38 MAPKs play an important role in signal transduction in response to cytokines, growth factors and other cellular stimuli. Specific responses ...
	Antisense modulation of CD44 expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...
	Antisense modulation of Smad7 expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...
	Antisense modulation of nucleolin expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...
	Antisense modulation of hnRNP A1 expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...
	Antisense inhibition of E2F transcription factor 3 expression OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid ...

0.004
Archive: All patents - Links Copyright (c)2006 Eipa-patents.org - All rights reserved