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Gene Therapy

Capillary-membrane-stabilization-and-reduction-of-tissue-injury-through-use-of-IV-biodegradable-macromolecules-with-antioxidants-and-or-other-chemicals

Separating epithelium from stroma in LASEK surgery

A surgical method according to the invention includes application of a solution containing ethanol ...

Making a lightly oxidized starch additive by adding a cationic polymer to starch slurry prior to heating the slurry

We claim: 1. An improved process for making gelatinous cationic starch useful in surface sizing and ...

Glucaric acid monoamides and their use to prepare poly(glucaramides)

OF THE INVENTION The novel alkali metal N-aminohydrocarbyl- and N-aminoheterohydrocarbyl-D-...

Process for preparing poly (glucaramides)

OF THE INVENTION The novel alkali metal N-aminohydrocarbyl- and N-aminoheterohydrocarbyl-D-...

Sheet supplying apparatus with centrally disposed feeding force

An object of the present invention is to provide a sheet supplying apparatus which can surely ...

High efficiency retroviral vector which contains genetically engineered cellular non-coding sequence harboring splicing acceptor

The objective of the present invention is to provide a safe and highly efficient retroviral vector ...

Nucleic acid probes and amplification oligonucleotides for Neisseria species

OF THE INVENTION A. Definitions The following terms have the indicated meanings in the ...

Site-specific protein modification

OF THE INVENTION Site specific modification of proteins and peptides provides a powerful research ...

Nucleic acid encoding gamma retinoic acid receptor fusion protein

What is claimed is: 1. A nucleic acid encoding a chimeric receptor having an N-terminus domain, a DN...

Method for specifically altering the nucleotide sequence of RNA

OF THE INVENTION The following words and phrases are defined, for reference in describing the ...

Capillary membrane stabilization and reduction of tissue injury through use of IV biodegradable macromolecules with antioxidants and/or other chemicals

Details

Inventors: Zikria, Bashir; Zikria, Jemal D.;
Assignee:
Primary Examiner: Wilson; James O.
Assistant Examiner: Owens; Howard V.
Attorney, Agent or Firm: Sommer; Evelyn M.

In accordance with the invention there is provided a method of treating a human subject to prevent leakage of serum proteins from capillary endothelial junctions during a period of increased capillary permeability. The invention also provides a method for preventing the harmful effects of free radicals on cellular membranes and other organelles. The method comprises administering to a subject an effective amount of a composition comprising at least one polysaccharide selected from the group consisting of hydroxyethyl starch and dextran of varying molecular sizes and at least one member of the group consisting of superoxide dismutase, glutathione peroxidase, catalase, hydroxyethyl rutoside, cyclic adenosine monophosphate and vitamin C. The compositions contain the macromolecules in a molecular size and concentration to effectively stabilize the capillary membrane. The stabilization effect is accomplished by a biophysical/biochemical process due to the adhesiveness and configuration of the macromolecules and because of their size. The treatment is benign as the macromolecules and antioxidants and non-toxic and biodegradable.

DETAILED DESCRIPTION We claim: 1.
Method of treating a human subject to prevent leakage of serum proteins from capillary endothelial junctions while simultaneously preventing the harmful effect of free radicals on cellular membranes and other organelles during a period of increased capillary permeability which comprises administering to a subject in need of such treatment an effective amount of a composition comprising at least one polysaccharide selected from the group consisting of hydroxyethyl starch and dextran and at least one antioxidant selected from the group consisting of superoxide dismutase, glutathione peroxidase, catalase, hydroxyethyl rutoside, cyclic adenosine monophosphate and vitamin C, in admixture with a pharmaceutically acceptable liquid carrier.
2.
Method according to claim 1 wherein said polysaccharide is hydroxyethyl starch.
3.
Method according to claim 1 wherein said polysaccharide is dextran.
4.
Method according to claim 1 wherein said polysaccharide is hydroxyethyl starch and dextran.
5.
Method according to claim 1 wherein said antioxidant is superoxide dismutase.
6.
Method according to claim 1 wherein said antioxidant is catalase.
7.
Method according to claim 1 wherein said antioxidant is glutathione peroxidase.
8.
Method according to claim 1 wherein said antioxidant is vitamin C.
9.
Method according to claim 1 wherein said antioxidant is vitamin C and glutathione peroxidase.
10.
Method according to claim 1 wherein said liquid carrier is a member selected from the group consisting of 0.
9% saline, 5% dextrose and Ringer'lactate.
11.
Method according to claim 1 wherein said polysaccharide is present in said composition in amount of about 3 to about 50%.
12.
Method according to claim 1 wherein said polysaccharide is present in said composition in amount of about 6 to about 12%.
13.
Method according to claim 1 wherein said composition is administered by intravenous injection in an amount of about 500 to 1500 ml per treatment.
14.
Method according to claim 5 wherein said superoxide dismutase is administered in amount of about 5000 to about 20,000 IU/kg per treatment

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