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Cephalosporin compound and process for preparing the same
| Details |
Inventors: Wagatsuma, Mitsuyoshi; Hatsuno, Susumu; Yamaguchi, Totaro; Ohshima, Satoshi;
Assignee: Tanabe Seiyaku Co., Ltd. (Osaka, JP)
Primary Examiner:
Assistant Examiner:
Attorney, Agent or Firm:
A cephalosporin compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a carboxy(lower)alkyl group, a hydroxy(lower)alkyl group, a carbamoyl(lower)alkyl group, an N-(lower)alkyl-carbamoyl(lower)alkyl group, a cycloalkyl group, a carboxycycloalkyl group, or a tetrazolylmethyl group, R.sup.2 is a hydrogen atom, a lower alkyl group, a formyl group or a lower alkanol group, R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 are combined together to form an aralkylidene group, or a pharmaceutically acceptable salt thereof which is useful as an antimicrobial agent, and process for their preparation. |
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DETAILED DESCRIPTION What is claimed is: 1.
A cephalosporin compound selected from the group consisting of a (Z) isomer of a compound of the formula: ##STR20## wherein R.
sup.
1 is methyl or tetrazolylmethyl and R.
sup.
2 and R.
sup.
3 are a hydrogen atom, or a pharmaceutically acceptable salt thereof.
2.
The cephalosporin compound of claim 1, which is 7.
beta.
-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-amino- 1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid or a pharmaceutically acceptable salt thereof.
3.
The cephalosporin compound of claim 1, which is 7.
beta.
-[2-(2-aminothiazol-4-yl)-(Z)-2-(tetrazol-5-yl-methoxyimino)acetami do]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid or a pharmaceutically acceptable salt thereof.
4.
An antibacterial composition comprising an effective antibacterial amount of the cephalosporin compound selected from the group consisting of a (Z) isomer of a compound of the formula: ##STR21## wherein R.
sup.
1 is methyl or tetrazolylmethyl and R.
sup.
2 and R.
sup.
3 are a hydrogen atom, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
5.
A method of treating an infectious disease caused by gram-positive or gram-negative bacteria in animals or humans which comprises administering thereto an effective antibaterial amount of the cephalosporin compound selected from the group consisting of a (Z) isomer of a compound of the formula: ##STR22## wherein R.
sup.
1 is methyl or tetrazolylmethyl and R.
sup.
2 and R.
sup.
3 are hydrogen atom, or a pharmaceutically acceptable salt thereof.
Description:
This invention relates to a novel cephalosporin compound and a process for preparing the same.
More particularly, it relates to a novel cephalosporin compound of the formula: ##STR2## wherein R.
sup.
1 is a hydrogen atom, a lower alkyl group, a carboxy(lower)alkyl group, a hydroxy(lower)alkyl group, a carbamoyl(lower)alkyl group, an N-(lower)alkyl carbamoyl(lower)alkyl group, a cycloalkyl group, a carboxycycloalkyl group or a tetrazolylmethyl group, R
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Gene Therapy 
