 PNA diagnostic methods |
| The present invention provides methods for detecting nucleic acid sequences and/or determining ... |
|
| Histidine-containing peptide nucleic acids |
| OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the ... |
|
| Two-step hybridization and capture of a polynucleotide |
| According to one aspect of the invention, there is disclosed a method of capturing a target ... |
|
| Peptide nucleic acid conjugates |
| OF THE INVENTION According to the present invention a PNA oligomer is conjugated to a ligand ... |
|
| High throughput assay system |
| This invention provides compositions, apparatus and methods for concurrently performing multiple ... |
|
| Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
| As previously discussed, the limited solubility of PNA oligomers, and particularly purine-rich ... |
|
| Neurologically-active compounds |
| The inventors have found a class of compounds which are surprisingly selective GABAC receptor ... |
|
| Once a day antihistamine and decongestant formulation |
| The present invention is a controlled release pharmaceutical formulation comprising effective ... |
|
| Thermostable isomerase and use hereof, in particular for producing tagatose |
| What is claimed is: 1. An L-arabinose isomerase capable of isomerizing D-galactose to D-tagatose, ... |
|
| Linear liquid dispensing pump for dispensing liquid in nanoliter volumes |
| What is claimed is: 1. In a rotary/reciprocating liquid dispensing pump including: a relatively ... |
|
|
Composition and method for treatment and prevention of traumatic synovitis and damage to articular cartilage
| Details |
Inventors: Marcum, Frank D.;
Assignee:
Primary Examiner: Wilson; James O.
Assistant Examiner: White; Everett
Attorney, Agent or Firm: Seanor, DVM.; J. W.
The invention provides compositions useful for the treatment and/or prevention of damage to diarthrodial (synovial) joints and, in particular, traumatic synovitis, inflammation of the synovial membrane, and damage to the articular cartilage of the joint. Specifically, provided are compositions specially formulated for intra-articular and/or parenteral use in the treatment and/or prevention of traumaticsynovitis and/or damage to articular cartilage. Compositions adapted specifically for post surgical joint lavage or treatment and/or prevention of inflammatory arthritis, osteoarthritis (OA) and/or degenerative joint disease (DJD) are also provided. Compositions adapted for intra-articular and/or systemic administration comprised of therapeutic amounts of: chondroitin sulfate; N-acetyl D-glucosamine; and hyaluronan (hyaluronic acid) are provided. |
|
DETAILED DESCRIPTION OF THE INVENTION Additional objects, advantages and other novel features of the invention will be set forth in part in the description that follows and in part will become apparent to those skilled in the art upon examination of the foregoing or may be learned with the practice of the invention.
Additionally, throughout this document, various publications and patents have been cited, the contents of which are incorporated herein by reference in their entirety.
Set forth in greater detail below are specific details related to novel compositions and methods for treatment and/or prevention of damage to articular cartilage in man and in animals.
In particular, the present invention provides specific teachings related to novel compositions and methods for intra-operative or post surgical intra-articular treatment of osteoarthritis and degenerative joint disease in the subject surgical animal.
In addition, the present invention provides compositions and surprisingly novel methods for the parenteral (systemic) treatment and/or prevention of synovitis, e.
g.
, traumatic synovitis due to mild injury or stress.
The examples set forth herein are in no way intended to limit the scope of the invention.
Those of skill in the art will realize that, given the teachings provided herein, many variations of the methods are possible that will fall within the scope of the of the invention.
In one embodiment, the invention provides a composition adapted for intra-articular injection, that is useful for the treatment and/or prevention of damaged articular cartilage of diarthrodial joints, the composition comprising therapeutic amounts of: chondroitin sulfate; N-acetyl D-glucosamine; and hyaluronan.
In particular, the compositions of the invention are adapted for use as an intra-articular joint lavage for use during and/or following surgery (arthrotomy or arthroscopic surgery) of the joint.
The glucosaminoglycans present in the compositions provided herein help to contribute to the return of homeostasis of the joint through the increase in the glucosaminoglycan pool used by chondrocytes for proteoglycan synthesis
|
| Related patents |
|
|
DNA sequences comprising dystrophin minigenes and methods of use thereof
The present invention provides dystrophin minigenes that are significantly reduced in size without compromising essential functions in protecting muscles from dystrophic ...
|
|
|
Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same
1. A composition for use in preparing an intron containing vector, said composition comprising: a donor vector comprising at least one splice site and an acceptor vector ...
|
|
|
Pharmaceutical composition and method for hypermetabolic weight loss
The present invention relates to a device, pharmaceutical composition and method for metabolizing fatty acids into water, carbon dioxide and heat and thereby reducing an ...
|
|
|
Method for manufacturing glycoproteins having human-type glycosylation
What is claimed is: 1. A method of manufacturing a glycoprotein having a sugar chain, comprising a step in which a transformed plant cell is produced by introducing to a ...
|
|
|
Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
What is claimed is: 1. A compound of the formula: ##STR2## wherein: a is from 0 to 6,: b is from 0 to 4; R, R' and R" are hydrogen, hydrocarbyl, heterosubstituted ...
|
|
|
Nucleic acid analogue induced transcription of double stranded DNA
We claim: 1. A method of transcribing RNA, using a double-stranded DNA as a template, comprising: (a) hybridizing said double-stranded DNA with a least one oligo-nucleic ...
|
|
|
Peptide nucleic acid combinatorial libraries
OF THE INVENTION The synthesis of peptide nucleic acids (also known as PNA) via preformed monomers were first described in PCT patent applications WO 92/20702, WO 92/207...
|
|
|
Nucleic acid-containing polymerizable complex
OF THE INVENTION The present invention is based on the development of a polymerizable complex comprised of a first polymerizable ethylene-containing monomer unit ...
|
|
|
Chiral peptide nucleic acids and methods for preparing same
OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the development of biological probes and new reagents for use in research (U...
|
|
|
Capillary electrophoretic detection of nucleic acids
OF THE PREFERRED EMBODIMENTS This invention provides novel methods for the detection and isolation of nucleic acids, nucleic acid fragments or other nucleic acid like ...
|
|
|
Gene Therapy 
