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Gene Therapy

Compositions-for-photodynamic-therapy

Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications

OF THE INVENTION The following examples are given to illustrate the invention, but should not be ...

Polyoxypropylene/polyoxyethylene copolmers with improved biological activity

Although the prior art preparations of polyoxypropylene/polyoxyethylene block copolymers may have ...

Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides

We claim: 1. A compound of the formula ##STR10## where (a) X.sup.1 is chlorine and X.sup.2 is ...

Nucleic acid probes immobilized on polystyrene surfaces

We claim: 1. An article of manufacture for use in a solution phase nucleic acid sandwich ...

Star polymers having multiple polyisobutylene arms emanating from a calixarene core, initiators therefor, and method for the synthesis thereof

What is claimed is: 1. A composition of matter comprising: a core component selected from the group ...

High molecular weight polymer-based prodrugs

The present invention addresses the shortcomings described above. In one aspect of the invention, ...

Non-antigenic branched polymer conjugates

OF THE INVENTION 1. POLYMER SUBSTITUENTS AND FORMULA (I) DEFINED The activated branched polymers ...

Substantially pure histidine-linked protein polymer conjugates

In one aspect, the present invention includes substantially pure protein-polymer conjugates. The ...

Crosslinked polymer compositions and methods for their use

The present invention discloses a crosslinked polymer composition comprising a first synthetic ...

Conjugation of polypeptides

OF THE INVENTION It is the object of the invention to provide polypeptide conjugates with reduced ...

Compositions for photodynamic therapy

Details

Inventors: Liu, Daniel;
Assignee: Quadra Logic Technologies Inc. (Vancouver, CA)
Primary Examiner: Raymond; Richard L.
Assistant Examiner:
Attorney, Agent or Firm: Irell & Manella

Porphyrin-type photosensitizers useful in photodynamic therapy can be formulated as water soluble drugs by conjugation of the photosensitizer to a hydrophilic polymer. Conjugation of the photosensitizer in varying ratios to the polymer, such as polyvinyl alcohol, provides compositions which are readily soluble and biodistribute in a fashion equal to or advantageous over that obtained when the photosensitizer is administered alone. In addition, these conjugates which further a contain target specific component provide a mechanism for homing to the desired target tissue, as well as offering a convenient approach to including both target specific component and photosensitizing drug in the same complex.

DETAILED DESCRIPTION I claim: 1.
A pharmaceutical composition useful for photodynamic therapy which composition contains, as active ingredient, a conjugate of a porphyrin-type photosensitizer with a hydrophilic, water soluble, multifunctional polymeric carrier, wherein the ratio of photosensitizer to carrier is 1:1 to 500:1.
2.
The pharmaceutical composition of claim 1 wherein said multifunctional polymeric carrier contains a multiplicity of amino or hydroxyl groups.
3.
The composition of claim 2 wherein said carrier is selected from the group consisting of a polysaccharide, polyallylamine, polyvinyl alcohol, and an esterified polyacrylate.
4.
The composition of claim 1 wherein the carrier is a polyvinyl alcohol.
5.
The composition of claim 1 wherein the porphyrin-type photosensitizer comprises a green porphyrin of formulas 1-6 of FIG.
1 wherein each R.
sup.
1 and R.
sup.
2 is independently selected from the group consisting of carbalkoxy (2-6C), alkyl (1-6C) sulfonyl, aryl (6-10C) sulfonyl, cyano, and --CONR.
sup.
5 CO-- wherein R.
sup.
5 is aryl (6-10C) or alkyl (1-6C); and wherein each R.
sup.
3 is lower alkyl (1-4C) or w-carboxalkyl (2-6C) or the esters or amides thereof.
6.
The composition of claim 5 wherein the green porphyrin is of formula 3 or 5 in FIG.
1 and wherein each R.
sup.
1 and R.
sup.
2 is independently carbalkoxy (2-6C) and each R.
sup.
3 is carbalkoxyethyl or carboxyethyl.
7.
The composition of claim 1 wherein the porphyrin-type photosensitizer is a mixture of porphyrins containing dihematoporphyrin ether.
8.
The composition of claim 1 wherein the ratio of photosensitizer to carrier is 10:1-75:1.
9.
The composition of claim 4 wherein the PVA has a molecular weight of .
about.
10,000 and the ratio of photosensitizer to PVA is 75:1-10:1.
10.
The composition of claim 1 wherein said conjugate further contains a target specific component.
11.
The composition of claim 10 wherein the ratio of target specific component to carrier is between about 5:1-1:1.
12.
The composition of claim 10 wherein said target specific component is an immunoglobulin or an immunoreactive fragment thereof

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