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Gene Therapy

Covalently-linked-complexes-and-methods-for-enhanced-cytotoxicity-and-imaging

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Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity

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Covalently-linked complexes and methods for enhanced cytotoxicity and imaging

Details

Inventors: Anderson, David C.; Morgan, Jr., A. Charles; Abrams, Paul G.; Fritzberg, Alan R.; Nichols, Everett J.;
Assignee: NeoRx Corporation (Seattle, WA)
Primary Examiner: Nucker; Christine M.
Assistant Examiner: Kim; Kay K.
Attorney, Agent or Firm:

Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.

DETAILED DESCRIPTION The present invention describes a covalently-linked complex (CLC) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction.
A method for enhancing in vivo cytotoxicity of a targeting protein conjugate comprising administering to a tumor-bearing patient a therapeutically effective amount of the covalently-linked complex of the present invention is also disclosed.
In addition, a method for enhanced in vivo imaging of a tumor comprising administering to a tumor-bearing patient a diagnostically effective amount of the claimed covalently-linked complex is disclosed.

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