Cryptophycins

DETAILED DESCRIPTION OF THE INVENTION The present invention provides novel cryptophycin compounds having the following structure: ##STR4## Wherein R.
sub.
1 is H, OH, a halogen, O of a ketone group, NH.
sub.
2, SH, a lower alkoxyl group or a lower alkyl group; R.
sub.
2 is H, OH, O of a ketone group, NH.
sub.
2, SH, a lower alkoxyl group or a lower alkyl group; or R.
sub.
1 and R.
sub.
2 may be taken together to form an epoxide ring, an aziridene ring, a sulfide ring or a second bond between C.
sub.
10 and C.
sub.
11 ; or R.
sub.
1 and R.
sub.
4 may be taken together to form a tetrahydrofuran ring; R.
sub.
3 is H or a lower alkyl group; R.
sub.
4 is OH, a lower alkanoyloxy group or a lower .
alpha.
-hydroxy alkanoyloxy group; R.
sub.
5 is H or an OH group; R.
sub.
6 is H; or R.
sub.
5 and R.
sub.
6 may be taken together to form a second bond between C.
sub.
5 and C.
sub.
6 ; R.
sub.
7 is a benzyl, hydroxybenzyl, methoxybenzyl, halohydroxybenzyl, dihalohydroxybenzyl, halomethoxybenzyl, or dihalomethoxybenzyl group; R.
sub.
8 is OH, a lower .
beta.
-amino acid wherein C.
sub.
1 is bonded to N of the .
beta.
-amino acid, or an esterified lower .
beta.
-amino acid wherein C.
sub.
1 is bonded to N of the esterified lower .
beta.
-amino acid group; R.
sub.
4 and R.
sub.
8 may be taken together to form a didepsipeptide group consisting of a lower .
beta.
-amino acid bonded to a lower .
alpha.
-hydroxy alkanoic acid; and R.
sub.
5 and R.
sub.
8 may be taken together to form a didepsipeptide group consisting of a lower .
beta.
-amino acid bonded to a lower .
alpha.
-hydroxy alkanoic acid; and with the following provisos: R.
sub.
1 is H, a lower alkyl group, or a lower alkoxyl group only if R.
sub.
2 is OH, O of a ketone group, NH2, SH; R.
sub.
2 is H, a lower alkyl group, or a lower alkoxyl group only if R.
sub.
1 is OH, O of a ketone group, NH.
sub.
2, SH; when R.
sub.
1 is OH, R.
sub.
2 is OH, R.
sub.
3 is methyl, R.
sub.
5 and R.
sub.
6 are taken together to form a second bond between C.
sub.
5 and C.
sub.
6, R.
sub.
4 and R.
sub.
8 are taken together to form the didepsipeptide group with the structure X: ##STR5## wherein O