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Home Gene Therapy Disaccharide-derivatives-for-treating-hyperglycaemia

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 Disaccharide derivatives for treating hyperglycaemia

Details
Inventors: Heinz, Fritz; Hertel, Sabine; Kunz, Markwart; Vogel, Manfred;
Assignee: Sudzucker Aktiengesellschaft Mannheim Ochsenfurt (DE)
Primary Examiner: Wilson; James O.
Assistant Examiner: Khare; Devesh
Attorney, Agent or Firm: Ostrolenk, Faber, Gerb & Soffen, LLP

The invention relates to the use of the disaccharide derivatives 3'-aminosucrose, sucrose-C6-acid and palatinose-C6'-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias.

DETAILED DESCRIPTION The invention claimed is: 1.
A drug composition comprising an active ingredient and a carrier in which said active ingredient is an amide or alkyl ester of an oxidized disaccharide and wherein the oxidized disaccharide is selected from the group consisting of monocarboxylic acids of sucrose and oxidized palatinose.
2.
A drug composition according to claim 1 in which the amide of an oxidized disaccharide has the general formula R'--CO--NHR in which R'--CO is the oxidized disaccharide and R is hydrogen or C.
sub.
1-5 alkyl.
3.
A drug composition according to claim 1 in which the alkyl ester is a methyl or ethyl ester of the oxidized disaccharide.
4.
A composition comprising a food and an additive in which the additive is an amide or alkyl ester of an oxidized disaccharide and wherein the oxidized disaccharide is selected from the group consisting of monocarboxylic acids of sucrose and oxidized palatinose.
5.
A composition according to claim 4 in which the amide of an oxidized disaccharide has the general formula R'--CO--NHR in which R'--CO is the oxidized disaccharide and R is hydrogen or C.
sub.
1-5 alkyl.
6.
A composition according to claim 4 in which the alkyl ester is a methyl or ethyl ester of an oxidized disaccharide.
7.
The drug composition of claim 1 wherein the monocarboxylic acid of sucrose is sucrose-C6-acid.
8.
The drug composition of claim 1 wherein the oxidized palatinose is palatinose-C6'-acid.




Description:
DESCRIPTION The invention relates to drug compositions and food compositions for treating hyperglycemias in the human or animal body and process for inhibiting .
alpha.
-glucosidases.
The breakdown of carbohydrates in the human or animal body requires the presence of .
alpha.
-glucosidases, in particular sucrases and maltases.
Inhibitors of these two enzymes prove to be advantageous, in particular if an increase in the blood sugar level after meals is to be prevented.
EP 0 560 284 A1 discloses .
alpha.
-glucosidase inhibitors which do not have harmful effects on the patient and in addition are taken by the patient only to a small extent



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