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| Capillary electrophoretic detection of nucleic acids |
| OF THE PREFERRED EMBODIMENTS This invention provides novel methods for the detection and isolation ... |
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| The present invention provides methods for detecting nucleic acid sequences and/or determining ... |
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| Histidine-containing peptide nucleic acids |
| OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the ... |
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| Two-step hybridization and capture of a polynucleotide |
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| Peptide nucleic acid conjugates |
| OF THE INVENTION According to the present invention a PNA oligomer is conjugated to a ligand ... |
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| High throughput assay system |
| This invention provides compositions, apparatus and methods for concurrently performing multiple ... |
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Endovascular cardiac venting catheter and method
| Details |
Inventors: Stevens, John H.; Krier, Jeffrey W.; Valley, Kirsten L.; Evard, Philip C.;
Assignee: Heartport, Inc. (Redwood City, CA)
Primary Examiner: Stright; Ronald
Assistant Examiner: Nguyen; A. T.
Attorney, Agent or Firm: Hoekendijk; Jens E., Grainger; Jeffry J.
A venting catheter, system and method are provided for withdrawing blood and other fluids from a patient's heart to facilitate decompressing the heart during cardioplegic arrest and cardiopulmonary bypass, without the need for a thoracotomy and without puncturing the aorta, pulmonary artery, or heart itself. The venting catheter is configured to be introduced into a peripheral vein and intralumninally advanced through the right side of the heart and into the pulmonary artery. The venting catheter includes a lumen configured to withdraw blood at a rate of at least about 50 ml/min at a pressure of no less than about -350 mmHg. A flow-directing means is provided to facilitate guiding the catheter into the pulmonary artery by being carried by blood flow through the heart. The cardiac venting system may include, in addition to the cardiac venting catheter, a cardiopulmonary bypass system to maintain circulation of oxygenated blood, and means for arresting the patient's heart. |
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DETAILED DESCRIPTION The present invention is directed to an endovascular approach for preparing a patient's heart for cardiac procedures which does not require a grossly invasive thoracotomy.
The invention facilitates venting fluids from a patient's heart while the heart is placed under cardioplegic arrest and circulation is maintained by a cardiopulmonary bypass system without necessitating a median sternotomy or other thoracic incision and without requiring punctures or incisions in the heart, aorta, pulmonary artery, or other vessels.
In a first aspect of the invention, a venting catheter is provided for withdrawing blood from a pulmonary artery connected to a right ventricle of a patient's heart.
The venting catheter comprises a flexible elongate shaft having a distal end, a proximal end, and an inner lumen extending from the proximial end to an inlet port at the distal end.
Usually, a plurality of inlet port are provided at the distal end in communication with the inner lumen.
The shaft has a length selected to allow the distal end to be positioned in the pulmonary artery with the proximal end extending transluminally to a peripheral vein and out of the patient through a puncture in the peripheral vein.
Usually, the shaft is at least about 40 cm in length to allow the venting catheter to be introduced into the internal jugular vein in the neck and advanced into the pulmonary artery via the superior vena cava.
The inner lumen is configured to allow blood to be withdrawn from the pulmonary artery at a rate of at least 50 ml/min.
at a pressure no lower than -350 mmHg.
In a specific embodiment, the inner lumen has cross-sectional area of at least 4.
0 mm.
sup.
2.
In a preferred embodiment, the venting catheter may include an expandable member mounted to the shaft near the distal end.
The expandable member may serve several purposes.
The expandable member may be configured to be carried by blood flow through the heart into the pulmonary artery.
In addition, the expandable member may be configured to occlude the pulmonary artery when expanded
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