Glycerin derivatives and inhibition of blood PAF

DETAILED DESCRIPTION OF THE INVENTION The glycerine derivatives of the invention are compounds of the formula ##STR3## wherein one of the residues R.
sup.
1, R.
sup.
2 and R.
sup.
3 is group U of the formula--OY.
sup.
1 or --X.
sup.
1 --C(O)--(A.
sup.
1).
sub.
n --Z.
sup.
1, another of the residues is group V of the formula --OY.
sup.
2 or --X.
sup.
2 --C(O)--(A.
sup.
2).
sub.
p --Z.
sup.
2, and the remaining residue is group W of the formula --X.
sup.
3 T--(C.
sub.
2-6 -alkylene)--N.
sup.
+ (Het)Q.
sup.
-, wherein one of X.
sup.
1, --X.
sup.
2 and X.
sup.
3 is oxygen or NH and the other two are oxygen, Y.
sup.
1 is C.
sub.
10-26 -alkyl or C.
sub.
10-26 -alkenyl, Y.
sup.
2 is C.
sub.
1-6 -alkyl, C.
sub.
2-6 -alkenyl, C.
sub.
3-6 -cycloalkyl, C.
sub.
5-6 -cycloalkenyl, phenyl, benzyl or 2-tetrahydropyranyl, A.
sup.
1 and A.
sup.
2, independently, are oxygen or NH, n and p are the integer 1 or 0, Z.
sup.
1 is C.
sub.
9-25 -alkyl or C.
sub.
9-25 -alkenyl, Z.
sup.
2 is C.
sub.
1-5 -alkyl, C.
sub.
2-5 -alkenyl, phenyl or, when (A.
sup.
2).
sub.
p is not oxygen, Z.
sup.
2 is also hydrogen, T is carbonyl, C(O)O or C(O)NH or, when X.
sup.
3 is oxygen, T is also methylene, --N.
sup.
+ (Het) is a 5- to 7-membered aromatic heterocyclic residue, optionally with an additional O-, S- or N-atom, optionally with a fused benzene ring and optionally monosubstituted by hydroxy, C.
sub.
1-4 -alkyl, C.
sub.
1-4 -alkoxy, 2-(hydroxy or amino)-ethyl, carbamoyl or ureido, and Q.
sup.
- is the anion of a strong inorganic or organic acid, and their hydrates.
The terms "alkyl" and "alkenyl" as used herein relate to straight-chain or branched, saturated or mono-unsaturated residues such as methyl, ethyl, propyl, isopropyl, 2-propenyl, butyl, isobutyl, hexadecyl, heptadecyl, octadecyl and octadecenyl, especially methyl and octadecyl.
Examples of C.
sub.
3-6 -cycloalkyl residues Y.
sup.
2 are cyclopropyl and cyclohexyl, examples of C.
sub.
5-6 -cycloalkenyl residues Y.
sup.
2 are 2-cyclopentenyl and especially 2-cyclohexenyl.
C.
sub.
2-6 -alkylene groups can be straight-chain or branched.
Examples thereof are n-butylene, 2-methylpropylene and especially ethylene and propylene