 Process for the synthesis of oligomeric compounds |
| What is claimed is: 1. A compound having the formula: ##STR38## wherein: X.sub.4 is Z or H; Z is CN,... |
|
| Processes for the synthesis of oligomeric compounds |
| OF PREFERRED EMBODIMENTS The present invention provides methods for the preparation of oligomeric ... |
|
| Methods of synthesis and use of radiolabelled platinum chemotherapeutic agents |
| OF THE INVENTION Usually, in the method of synthesis of the radiolabelled platinum ... |
|
| Pharmaceutical composition for diabetic neuropathy |
| What is claimed is: 1. A method for the prophylaxis of diabetic peripheral neuropathy, which ... |
|
| Rapid single-cycle assay for human immunodeficiency virus type-1 drug resistance |
| This invention aids in fulfilling this need in the art by providing an in vitro, single cycle, ... |
|
| Compositions and methods for sensitive detection of HIV infection and monitoring of drug resistance |
| OF THE INVENTION The present invention relates to new and useful methods including methods for ... |
|
| Continuous process for ethanol production by bacterial fermentation |
| The accompanying FIGURE will provide a background for the following discussion in which the method ... |
|
| Stable solution of hyaluronate in a balanced salt medium |
| What is claimed is: 1. A physiological visco-elastic formulation consisting of sodium hyaluronate ... |
|
| Radiolabeled fusion toxins for cancer therapy |
| The present invention describes the synthesis and purification of a new class of compounds known as ... |
|
| Genetically modified cells expressing a TGF.beta. inhibitor, the cells being lung cancer cells |
| OF THE PREFERRED EMBODIMENT Lung cancers account for 30% of all death due to cancer in the United S... |
|
|
Hepatitis C virus inhibitors
| Details |
Inventors: Scola, Paul Michael; Campbell, Jeffrey Allen; Sin, Ny; Sun, Li-Qiang; Wang, Xiangdong Alan;
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Primary Examiner: Campell; Bruce R.
Assistant Examiner: Heard; Thomas S.
Attorney, Agent or Firm: Mingo; Pamela A. Volles; Warren K.
Hepatitis C virus inhibitors are disclosed having the general formula: ##STR00001## wherein A, R.sub.2, R.sub.3, R', B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed. |
|
DETAILED DESCRIPTION OF THE INVENTION Stereochemical definitions and conventions used herein generally follow McGraw-Hill Dictionary of Chemical Terms, S.
P.
Parker, Ed.
, McGraw-Hill Book Company, New York (1984) and Stereochemistry of Organic Compounds, Eliel, E.
and Wilen, S.
, John Wiley & Sons, Inc.
, New York (1994).
Many organic compounds exist in optically active forms, i.
e.
, they have the ability to rotate the plane of plane-polarized light.
In describing an optically active compound, the prefixes D and L or R and S are used to denote the absolute configuration of the molecule about its chiral center(s).
The prefixes d and 1 or (+) and (-) are employed to designate the sign of rotation of plane-polarized light by the compound, with (-) or 1 meaning that the compound is levorotatory and (+) or d, meaning the compound, is dextrorotatory.
For a given chemical structure, these compounds, called stereoisomers, are identical except that they are mirror images of one another.
A specific stereoisomer of a mirror image pair may also be referred to as an enantiomer, and a mixture of such isomers is often called an enantiomeric mixture.
With reference to the instances where (R) or (S) is used, it is to designate the absolute configuration of a substituent in context to the whole compound and not in context to the substituent alone.
Unless otherwise specifically noted herein, the terms set forth below will have the following definitions.
The terms "racemic mixture" and "racemate" refer to an equimolar mixture of two enantiomeric species, devoid of optical activity.
The term "chiral" refers to molecules which have the property of non-superimposability of the mirror image partner, while the term "achiral" refers to molecules which are superimposable on their mirror image partner.
The term "stereoisomers" refers to compounds which have identical chemical composition, but differ with regard to the arrangement of the atoms or groups in space.
The term "diastereomer" refers to a stereoisomer which is not an enantiomer, e
|
|
Gene Therapy 
