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Dense star polymers and dendrimers
OF ILLUSTRATIVE EMBODIMENTS In the dense star polymers of the present invention, the core is covalently bonded to at least one core branch, preferably at least two, ...
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Glycerin derivatives and inhibition of blood PAF
OF THE INVENTION The glycerine derivatives of the invention are compounds of the formula ##STR3## wherein one of the residues R.sup.1, R.sup.2 and R.sup.3 is group U of ...
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Oligonucleotide derivatives and production thereof
Gist In view of the state of the art as described above, the present inventors have developed an immobilized oligonucleotide which is useful in purification of nucleic ...
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Process for synthesizing macrocyclic chelates
The invention is a process for synthesizing a 12 membered ring tetraaza macromolecule. The process involves condensing an amide of ethylene diamine having a general ...
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Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
I claim: 1. A method for producing a 1:1 protein:anitbody tioether-linked immunoconjugate as a predominant species, comprising the steps of: combining a protein selected ...
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Compositions for photodynamic therapy
I claim: 1. A pharmaceutical composition useful for photodynamic therapy which composition contains, as active ingredient, a conjugate of a porphyrin-type ...
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Amplifier molecules for enhancement of diagnosis and therapy
As used herein, an "amplifier" or "amplifier molecule" is a chemical compound having a multiplicity of terminal amine moieties, each serving as a locus to which one or ...
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Peptide-containing polyethylene glycol derivatives and application thereof
OF THE PREFERRED EMBODIMENTS The present invention will hereinafter be explained in more detail. The peptide-containing polyethylene glycol derivatives of the present ...
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Modified HIL-6
OF THE INVENTION Described below is the chemical modification with PEG of at least one amino group of polypeptides possessing IL-6 activities. This modification results ...
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Construction of geometrical objects from polynucleotides
By means of the present invention, DNA, RNA and similar polymers may be produced by synthesizing a double stranded segment, preferably with a loop at one end, cleaving ...
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