DETAILED DESCRIPTION To accomplish those objectives, the present invention provides hydrophobic muiticomponent heparin conjugates in which heparin is coupled with macromolecules and hydrophobic materials.
The present invention also provides a method of the preparing the hydrophobic multicomponent heparin conjugates.
This invention also provides a method of use of the hydrophobic multicomponent heparin conjugates as a coating agent for the surface modification of all medical instruments or artificial organs.
Hydrophobic multicomponent heparin conjugates of the present invention are heparin coupled with macromolecules containing multi-functional groups, in which the binding ratio of heparin and macromolecule can be controlled, and wherein amine groups among the functional groups of heparin are used for binding with macromolecules.
Heparin has carboxyl groups, hydroxyl groups, sulfonic acid groups, and amine groups as functional groups.
All the functional groups except amine groups exist in the active site of anti-thrombosis; thus, when those functional groups are used for binding with macromolecules, these heparin-macromolecule conjugates lose their anti-thrombosis activity.
Synthetic macromolecules, proteins, biopolymers, and their mixtures can be used as macromolecules containing the aforementioned multi-functional groups.
For synthetic macromolecules, polydienes, polyalkenes, polyacetylenes, polyacrylic acid and its derivatives, poly .
alpha.
-substituted acrylic acid and its derivatives, polyvinyl ethers, polyvinylalcohol, polyvinyl halides, polystyrene and its derivatives, polyoxides, polyethers, polyesters, polycarbonates, polyamides, polyamino acids, polyureas, polyurethanes, polyimines, polysulfides, polyphosphates, polysiloxanes, polysilsesquioxanes, polyheterocyclics, cellulose and its derivatives, polysaccharides, and their copolymers or derivatives can be used.
For proteins, protamine, polylysine, polyaspartic acid, polyglutamic acid and its derivatives or copolymers can be used
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