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| Capillary electrophoretic detection of nucleic acids |
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| Two-step hybridization and capture of a polynucleotide |
| According to one aspect of the invention, there is disclosed a method of capturing a target ... |
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| Peptide nucleic acid conjugates |
| OF THE INVENTION According to the present invention a PNA oligomer is conjugated to a ligand ... |
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| High throughput assay system |
| This invention provides compositions, apparatus and methods for concurrently performing multiple ... |
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| Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
| As previously discussed, the limited solubility of PNA oligomers, and particularly purine-rich ... |
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| Neurologically-active compounds |
| The inventors have found a class of compounds which are surprisingly selective GABAC receptor ... |
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| Once a day antihistamine and decongestant formulation |
| The present invention is a controlled release pharmaceutical formulation comprising effective ... |
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LSR receptor, activity, cloning, and uses for diagnosing, preventing and/or treating obesity and related risks or complications
| Details |
Inventors: Bihain, Bernard; Bougueleret, Lydie; Yen-Potin, Frances;
Assignee: Genset, S.A. (FR); Institute National de la Sante et de la Recherche Medicale (INSERM) (FR)
Primary Examiner: Spector; Lorraine
Assistant Examiner: O'Hara; Eileen B.
Attorney, Agent or Firm: Saliwanchik, Lloyd & Saliwanchik
The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds which can be used as medicament for the prevention and/or treatment of pathologies and/or of pathogeneses such as obesity and anorexia, hyperlipidemias, atherosclerosis, diabetes, hypertension, and more generally the various pathologies associated with abnormalities in the metabolism of cytokines. |
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DETAILED DESCRIPTION The LSR receptor The invention relates to a purified LSR receptor (<<Lipolysis Stimulated Receptor>>), preferably hepatic, consisting of at least one .
alpha.
or .
alpha.
' subunit and at least one .
beta.
subunit.
The .
alpha.
subunit has a molecular weight of about 66 kDa in rats and in mice and of about 72 kDa in humans.
The .
alpha.
' subunit has a molecular weight of about 64 kDa in rats and in mice and of about 70 kDa in humans.
The .
beta.
subunit has a molecular weight of about 58 kDa in rats and in mice and of about 64 kDa in humans.
The inventors have formulated the hypothesis according to which the most abundant, and probably the most active, form of the LSR receptor is that in which an .
alpha.
or .
alpha.
' subunit and three .
beta.
subunits exist.
It appears, however, possible that the .
alpha.
and .
alpha.
' subunits, on the one hand, and the .
beta.
subunit, on the other, have distinct biological functions and that these functions can be performed in a cell independently of their assembly in the form of a receptor.
The inventors have also observed that a complex can form between the LSR receptor and the gC1qR receptor having a molecular weight of about 33 kDa, or a homologous protein.
It appears that the gC1qR receptor is transiently combined with the LSR receptor and that the presence of a C1q protein or of homologous proteins makes it possible not only to dissociate gC1qR from the LSR receptor but also to activate the LSR receptor, including in the absence of fatty acids.
Activity of the LSR Receptor and Applications The present invention therefore relates to a receptor, in particular of hepatic cells, characterized in that it is capable, in the presence of free fatty acids, of binding lipoproteins, and in the absence of free fatty acids, of binding a cytokine, preferably the bound leptin, lipoproteins and cytokine being incorporated and then degraded by the cell, it being possible for the said receptor, in addition, to bind the gC1qR protein or one of its analogous proteins
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