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Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
The present invention describes a covalently-linked complex (CLC) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an ...
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Compositions and methods for drug delivery using pH sensitive molecules
We claim: 1. A process for transfecting a nucleic acid into a cell in vivo, comprising: a) attaching a membrane activity inhibitor to a membrane active peptide via a ...
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Chiral peptide nucleic acid monomers and oligomers
What is claimed is: 1. A peptide nucleic acid monomer having the formula: ##STR5## wherein: B is a naturally or non-naturally ocurring nucleobase; n is 0, 1, 2, or 3; ...
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Enzymatic DNA molecules
The present invention thus contemplates a synthetic or engineered (i.e., non-naturally-occurring) catalytic DNA molecule (or enzymatic DNA molecule) capable of cleaving ...
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Multigene vectors
The present invention provides a method for preparing HSV vectors. The method comprises co-transfecting a source vector and a mutating cassette together into a ...
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Composition and method for inhibiting platelet aggregation
OF THE INVENTION This invention is provides a method of preventing or treating diseases or conditions associated with platelet aggregation. The method also provides a ...
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Nucleic acid probes
OF THE INVENTION "Derivatizable" nucleotides are nucleotides modified so as to include at the 4-position of a pyrimidine a functional group which can react with a ...
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Assay for antiviral activity using complex of herpesvirus origin of replication and cellular protein
The drawings are first described. FIG. 1 is a diagram of the HSV-1 genome and oriS. FIG. 1A indicates the locations of the three origins of DNA replication and the ...
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Substrate for detection of mammalian 5-C-DNA methyltransferase
OF THE INVENTION "Oligomeric DNA" or ODN, as used herein, means a DNA having from 10 to 75 "purine or pyrimidine bases" connected in a series of nucleotides which are ...
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Vinyl ethers of nucleoside analogs
OF THE INVENTION The compounds of the present invention can exist as optical isomers. Both the racemic and diasteromeric mixtures of these isomers which may exist for ...
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