Lymphatic delivery composition

DETAILED DESCRIPTION We claim: 1.
A composition capable of delivering an active agent to the lymphatic system comprising a plurality of colloidal particles having an active agent associated with each particle, wherein the particles consist essentially of particles having a size in the rage of between one and 250 nm and the surface of each particle has a hydrophobicity ratio determined by hydrophobic interaction chromatography of less than or equal to about 10.
2.
The composition of claim 1 wherein the hydrophobicity ratio is less than 5.
3.
A composition capable of delivering an active agent to the lymphatic system comprising a plurality of colloidal particles and an active agent associated with each particle, wherein a modifying agent is adsorbed onto or attached to the surface of each particle, such that the modifying agent gives and advancing contact angle of less than about 60.
degree.
.
4.
A composition capable of delivering an active agent to the lymphatic system comprising a plurality of colloidal particles and an active agent associated with each particle wherein a modifying agent is adsorbed onto or attached to the surface of each particle such that the thickness of the layer of modifying agent is about 0.
8 to 4.
0 nm.
5.
A composition capable of delivering an active agent to the lymphatic system comprising a plurality of colloidal particles and an active agent associated with each particle wherein a modifying agent is adsorbed onto or attached to the surface of each particle such that the albumin uptake ratio (AUR) of the surface is between about 0.
2 and 0.
5.
6.
A composition capable of delivering an active agent to the lymphatic system comprising a plurality of colloidal particles and an active agent associated with each particle wherein a modifying agent is adsorbed onto or attached to the surface of each particle such that the thickness of the layer of modifying agent is less than about 10 nm and the surface of each particle has a hydrophobicity ratio of less than 5.
7.
The composition of claim 3 wherein the modifying agent is adsorbed onto or attached to the surface of each particle such that the thickness of the layer of modifying agent is less than about 10 nm