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Details
Inventors: Siren, Matti;
Assignee: Perstorp AB (Perstorp, SE)
Primary Examiner: Schenkman; Leonard
Assistant Examiner: Criares; T. J.
Attorney, Agent or Firm: Scully, Scott, Murphy & Presser

A method of reducing the negative effect of cadmium or aluminum ion or free-radicals in body tissues and a method of alleviating cardiovascular diseases and conditions by administering to a human or an animal a pharmaceutical composition comprising an amount of at least one specific isomer of inositol triphosphate sufficient to obtain said alleviation.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS As examples of the diseases which the method according to the invention is useful to prevent or alleviate, there are mentioned eye diseases such as retinitis pigmentosa or damage of different parts of the eye such as the lens, a lung disease such as bronchitis, emphysema or lung fibrosis, an inflammatory condition such as arthritis, high blood pressure, cardiovascular diseases such as artherosclerosis or increase of platelet aggregation, diabetes, cell proliferation changes, damage to the central nervous system, a thrombotic condition such as damage to the endothelium, increase of platelet aggregation or inhibition of the prostacycline production, a hyperlipidaemic condition such as increased cholesterol levels, a light induced disease such as skin damages.
It is believed that at least some of the above diseases are caused or aggravated by the presence of cadmium, aluminum or free-radicals, but the invention is not limited by said theory, since the method according to the invention is useful against said diseases whatever reason behind them.
The method according to the invention is also intended to facilitate or improve transplant of different organs and to regulate unnormal levels of metal ions in the body.
For production of the isomer or isomers of IP.
sub.
3 which accomplish the above objectives and which is present in the composition used in the method according to the invention, one or more of the compounds IP.
sub.
6, IP.
sub.
5 or IP.
sub.
4 or a natural product containing at least one of these compounds can be used as a starting material.
In the cases where the starting material is a natural product, one with a content of at least 0.
3%, preferably at least 1% of inositol phosphate (IP.
sub.
6 +IP.
sub.
5 +IP.
sub.
4) is preferably chosen.
Particularly suitable products are beans, bran, pollen and oil plants.
The IP.
sub.
3 isomers present in the composition used according to the invention can, for example, be produced by enzymatic breakdown starting from IP



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