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Thymidine kinase mutants
Briefly stated, the present invention provides compositions and methods which utilize Herpesviridae thymidine kinase mutants. Within one aspect of the present invention, ...
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Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
We claim: 1. An enzymatic nucleic acid molecule comprising a 5'-cap structure, a 3'-cap structure, or both a 5'- and a 3'-cap structure, wherein said 5'-cap structure is ...
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Peptide acceptor ligation methods
What is claimed is: 1. A method of affixing a peptide acceptor to an RNA molecule, said method comprising: (a) providing an RNA molecule having a 3' sequence which forms ...
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Solid phase diagnosis of medical conditions
I claim: 1. A method for detecting a target polynucleotide that is characteristic of a pathological condition, comprising the steps of: (a) producing a first amplified DN...
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Use of microparticles combined with submicron oil-in-water emulsions
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional methods of chemistry, biochemistry, molecular biology, ...
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Methods of treating hypertension and compositions for use therein
The present invention provides methods of treating hypertension, particularly essential hypertension. The methods generally involve providing a stimulator of ...
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Use of microparticles combined with submicron oil-in-water emulsions
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional methods of chemistry, biochemistry, molecular biology, ...
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6,11-bicyclic erythromycin derivatives
OF THE INVENTION A first embodiment of the present invention is a compound of formula I as defined herein, or its pharmaceutically acceptable salt, ester, or prodrug. R...
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Method of producing infectious reovirus
OF THE INVENTION The present invention is directed to a method of producing mammalian reovirus by using human embryo kidney 293 (HEK 293) cells. We found that HEK 293 ...
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CDNA sequences of human bone matrix proteins
It is, therefore, an object of the present invention to provide specific cDNA and deduced protein sequences which are diagnostic of such human diseases as osteoporosis, ...
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