Inventors: Klucher, Kevin M.; Sivakumar, Pallavur V.; Kindsvogel, Wayne R.; Henderson, Katherine E.;
Assignee: ZymoGenetics, Inc. (Seattle, WA)
Primary Examiner: Brumback; Brenda
Assistant Examiner: Hamud; Fozia
Attorney, Agent or Firm: Walsh; Brian J.
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections. |
Gene Therapy 
