Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX

DETAILED DESCRIPTION The invention provides an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human glycoprotein Ib/IX complex.
This peptide is called a mimotope.
In one preferred embodiment, the monoclonal antibody is designated C-34, and the peptide includes an amino acid sequence selected from the group consisting of: SEQ ID NO:1: AWNWRYREYV SEQ ID NO:2: KWNWRNKKYV SEQ ID NO:3: LSTWRYFEYV SEQ ID NO:4: YLGWRYSEYV SEQ ID NO:5: TQMWRAREYL SEQ ID NO:6: WRQREYWDPV SEQ ID NO:7: EGSWRYRKGG SEQ ID NO:8: GYHWWRNWEY SEQ ID NO:9: KGFLWRARNW SEQ ID NO:10: MNWKHWRARH SEQ ID NO:11: FKWREWRGKL SEQ ID NO:12: PDRQVRLWVR SEQ ID NO:13: RVLRHWHPRT SEQ ID NO:14: GRRVWMLNHG SEQ ID NO:15: KKGRHHVTRV SEQ ID NO:16: GGVCKCWQCL SEQ ID NO:17: FSHSYGSAIR SEQ ID NO:18: MHGHRRPGLA SEQ ID NO:19: MSKKPHLGLR SEQ ID NO:20: TMWVELYSLK SEQ ID NO:21: FVDPGRAGRG SEQ ID NO:23: FRCCVFSCCLLS SEQ ID NO:24: GFRCLVSLGGCF SEQ ID NO:25: YSLWGLPVGDVV SEQ ID NO:26: LPLLWFNGAGFF SEQ ID NO:27: VWGLFRGLENGS SEQ ID NO:28: SLWRQWRGLFVV SEQ ID NO:29: TLSLFGGRDKGF SEQ ID NO:30: IGPAVSCLFRVC SEQ ID NO:31: MSLFPLSFCRLI SEQ ID NO:32: ALFSSVWGDVTL SEQ ID NO:33: GWFGPFWVRGSG SEQ ID NO:34: FWVSVGGVEGVV SEQ ID NO:35: LGAFGGAGFLWR SEQ ID NO:36: CRGIVFLFVGWL SEQ ID NO:37: FWLVKGAGAWRF SEQ ID NO:39: QVRLWARAGAGQ SEQ ID NO:40: GLAVTFGSVLEG SEQ ID NO:41: VRWMCVIRLGVR SEQ ID NO:42: RLWGPGVSRPVL SEQ ID NO:43: CGSSLFRGPRCP SEQ ID NO:44: LGISSLSFLQLR SEQ ID NO:45: TWGWDGVSYLFL SEQ ID NO:46: TRSLFDDFVSLR SEQ ID NO:47: CYASLFRSRLCA SEQ ID NO:48: DGSVRVVWVRLL SEQ ID NO:49: LSGFPVALVRFA SEQ ID NO:50: LGGGLLVGSVFP SEQ ID NO:51: VWARGVFRDRFF SEQ ID NO:52: TGLLAGPVWRWT SEQ ID NO:53: WLGGIFSCLVCG SEQ ID NO:54: WFLRDVGCGSCL SEQ ID NO:55: SRCGVFTWCSRS SEQ ID NO:56: RCLVGYRCWGGV SEQ ID NO:57: GFRCLVMGGGCA SEQ ID NO:58: CGFDLVCARLFG SEQ ID NO:59: DSGVRWFFGFLG SEQ ID NO:60: ILDGCFFLGRCP SEQ ID NO:61: CVRWLVSAGCSG SEQ ID NO:62: CVGCWLVCDVLL SEQ ID NO:63: CLFVFAAGFACG SEQ ID NO:64: SCALFGSCFGIS SEQ ID NO:65: CWGGVGVCGLLV SEQ ID NO:66: KRAWWKQKWV SEQ ID NO:67: CVGGVASRCGVL SEQ ID NO:68: SGAVLAGPFGVW SEQ ID NO:69: CRAFDRVGVCVW SEQ ID NO:70: RCLVGYVVWGGVW SEQ ID NO:71: VCLVYRSVDCWA SEQ ID NO:72: WRVFVFTCVVWA SEQ ID NO:73: LWREWRGLFAVL SEQ ID NO:74: SGAVLAGPLWRL SEQ ID NO:75: FVVRGGTFLFVR SEQ ID NO:77: TGLLAGPVWRWT SEQ ID NO:78: DSGVRWFFGFLG SEQ ID NO:79: CAWHRLSFCGLV SEQ ID NO:80: CFGSALVLAVLA and SEQ ID NO:81: WFWDMSGEWGGL