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 Nucleic acids encoding JTT-1 protein

Details
Inventors: Tamatani, Takuya; Tezuka, Katsunari;
Assignee: Japan Tobacco, Inc. (Tokyo, JP)
Primary Examiner: Gambel; Phillip
Assistant Examiner: Ouspenski; Ilia
Attorney, Agent or Firm: Fish & Richardson P.C.

Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have been isolated, identified, and analyzed for their functions. The cell surface molecules are expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes, and induce cell adhesion. Antibodies against the cell surface molecules significantly ameliorate pathological conditions of autoimmune diseases and allergic diseases.

DETAILED DESCRIPTION What is claimed is: 1.
An isolated nucleic acid comprising a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
2.
The nucleic acid of claim 1, wherein the polypeptide consists of the amino acid sequence of SEQ ID NO:2.
3.
The nucleic acid of claim 1, wherein the nucleic acid comprises SEQ ID NO:1.
4.
A transfonnant identified by international deposit accession No.
FERM BP-5725.
5.
An isolated nucleic acid comprising a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2 in which one to ten amino acids are substituted, deleted or added; wherein, (a) the polypeptide comprises the amino acid sequence Phe-Asp-Pro-Pro-Pro-Phe (SEQ ID NO:21) in its extracellular region, (b) the polypeptide comprises the amino acid sequence Tyr-Met-Phe-Met (SEQ ID NO:22) in its cytoplasmic region, and (c) an antibody reactive with the polypeptide induces proliferation of peripheral blood lymphocytes in the presence of an antibody reactive with CD3.
6.
The nucleic acid of claim 5, wherein the polypeptide consists of the amino acid sequence of SEQ ID NQ:2 in which one to ten amino acids are substituted, deleted or added.
7.
An isolated nucleic acid comprising a nucleotide sequence that encodes a polypeptide comprising: (a) an extracellular region of the protein set forth in SEQ ED NO:2, or (b) an extracellular region of a protein that consists of the amino acid sequence of SEQ ID NO:2 in which one to ten amino acid residues are substituted, deleted or added; wherein the polypeptide comprises the amino acid sequence Phe-Asp-Pro-Pro-Pro-Phe (SEQ ID NO:21) and inhibits the activation of lymphocytes.
8.
The nucleic acid of claim 7, wherein the polypeptide consists of: (a) an extracellular region of the protein set forth in SEQ ID NO:2, or (b) an extracellular region of a protein that consists of the amino acid sequence of SEQ ID NO:2 in which one to ten amino acid residues are substituted, deleted or added


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