Peptide-containing polyethylene glycol derivatives and application thereof

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will hereinafter be explained in more detail.
The peptide-containing polyethylene glycol derivatives of the present invention are represented by the following general formula [I] or [II]; ##STR3## In the formulae [I] and [II], ionic groups present in the molecule may form salts with appropriate counter ions, and each R.
sup.
1 independently represents a peptide residue represented by the following general formula [IIIa] or [IIIb]; -([X]-Arg-Gly-Asp-[Y]).
sub.
m -Z [IIIa] ([X]-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-[Y]).
sub.
m [IIIb](SEQ ID NO: 1), as ([X]-[SEQ ID NO:1)-[Y]).
sub.
m In the formulae [IIIa] and [IIIb], Arg, Gly, Asp, Glu, Ile, Leu, Val, Pro, Ser and Thr represent arginine, glycine, aspartic acid, glutamic acid, isoleucine, leucine, valine, proline, serine and threonine residues respectively.
[X] and [Y] independently represents an amino acid or peptide residue which may be independently present or absent.
If one or both of them are present, they preferably represent an amino acid residue selected from the group consisting of serine, glycine, valine, asparagine, proline, cysteine and threonine residues or a peptide residue constituted by the foregoing amino acid residues, and the number of amino aci residues constituting the peptide residue is preferably 2 or 3.
In particular, [X] preferably represents a glycine residue and [Y] preferably represents a serine residue or a serine-proline peptide residue or preferably both [X] and [Y] are absent.
The number of n is an integer ranging from 1 to 150, preferably 5 to 120, m is an integer ranging from 1 to 5, preferably 1 to 3, and Z represents --OH or --NH.
sub.
2.
The peptide residue [IIIb] is bonded to the triazine ring at the position [X] (or if [X] is absent, at the position of Glu residue) or [Y] (or if [Y] is absent, at the position of Thr residue).
As the salts of the compounds of the present invention, there may preferably be mentioned, for instance, sodium, potassium, ammonium and magnesium salts as well as hydrochlorides, sulfates, nitrates and acetates