DETAILED DESCRIPTION OF THE INVENTION In accordance with the invention novel therapeutic use is provided for certain active agents, particularly adenosine receptor agonists and antagonists.
By one embodiment, the G-CSF-inducing embodiment, some such agents are used to mediate the production and secretion of G-CSF from cells.
In accordance with another embodiment, the toxicity-preventing embodiment, some such agents are used to counter toxic side effects of drugs, e.
g.
chemotherapeutic or nemoleptic drugs.
In a further embodiment, the leukopenia-prevention embodiment, some such agents are used to counter leukopenia, particularly drug-induced leukopenia.
In accordance with yet another embodiment, the proliferation-inhibition embodiment, some such agents are used to selectively inhibit abnormal cell growth.
The term "leukopenia" as used herein refers to the reduction in the circulating white blood cell count.
While leukopenia is usually characterized by a reduced number of blood neutrophils (neutropenia), at times, a reduced number of lymphocytes, monocytes, eosinophils or basophils may be detected.
Leukopenia which may arise from the reduced production or excessive splenic sequestration of neutrophils, may result from a hereditary and congenital diseases.
However it is mainly observed after treatment with drugs, such as cytoreductive cancer drugs, antithyroid drugs, phenothiazines, anticonvulsants penicillins, sulfonamides, and chloramphenicol.
Some antineoplastics cause leukopenia as a predictable side effect.
In the following, a reduction in leukocyte count or neutrophil count by drugs will be referred to herein, as "drug-induced leukopenia" or "drug-induced neutropenia".
Furthermore, whenever mention is made to leukopenia, it should be understood as referring particularly to "neutropenia".
Further, the term "prevention or treatment of leukopenia" should be understood as a procedure whereby the reduction in leukocyte cell count which may otherwise occur, is reduced, totally prevented or if such reduction has occurred, a procedure which gives rise to increase in the leukocyte cell count
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Gene Therapy 
