DETAILED DESCRIPTION What is claimed is: 1.
An immunogenic composition suitable for administration by injection, which comprises antigenic determinants of at least two papillomavirus proteins selected from the group consisting of L1, L2, E1, E2, E3, E4, E5, E6, and E7, in an amorphous reaggregated form which when in solution or dispersion can pass through a sterilization filter.
2.
An immunogenic composition according to claim 1, wherein at least one of the two papillomavirus proteins is selected from the group consisting of E1, E2, E3, E4, E5, E6, and E7.
3.
An immunogenic composition according to claim 1, wherein said polypeptide or polypeptide composition comprises a sequence fragment of at least 50% of the full sequence of at least one of the selected papillomavirus proteins.
4.
An immunogenic composition according to claim 1, wherein the antigenic determinant is of a papillomavirus protein of HPV type 6, 11, 16, 18, or of a non-human animal papillomavirus.
5.
An immunogenic composition according to claim 1, in the form of a denatured, reduced, and reaggregated preparation.
6.
An immunogenic composition according to claim 5, which comprises aggregate particles having from 2-200 polypeptide chains per aggregate.
7.
An immunogenic composition according to claim 5, which comprises aggregate pariticles having from 5-50 polypeptide chains per aggregate.
8.
An immunogenic composition according to claim 1, obtainable by denaturation, or denaturation with reduction, and subsequent reaggregation of a polypeptide expressed in the form of inclusion bodies in a recombinant host cell.
9.
An immunogenic composition according to claim 8, which has a molecular mass per aggregate in the range about 100,000 to about 10,000,000 dalton.
10.
An immunogenic composition according to claim 8, which comprises aggregate particles with diameters on electron microscopy in the range of about 4 to 50 nm.
11.
An immunogenic composition according to claim 8, which comprises aggregate particles with diameters on electron microscopy in the range of about 10-15 nm
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Gene Therapy 
