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Gene Therapy

Process-for-synthesizing-macrocyclic-chelates

Biologically compatible linear block copolymers of polyalkylene oxide and peptide units

INCLUSIVE OF PREFERRED EMBODIMENTS We have discovered that linear block copolymers comprising ...

Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces

The present invention provides for compounds having the formula: ##STR1## wherein R.sub.1 is ...

Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications

OF THE INVENTION The following examples are given to illustrate the invention, but should not be ...

Polyoxypropylene/polyoxyethylene copolmers with improved biological activity

Although the prior art preparations of polyoxypropylene/polyoxyethylene block copolymers may have ...

Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides

We claim: 1. A compound of the formula ##STR10## where (a) X.sup.1 is chlorine and X.sup.2 is ...

Nucleic acid probes immobilized on polystyrene surfaces

We claim: 1. An article of manufacture for use in a solution phase nucleic acid sandwich ...

Star polymers having multiple polyisobutylene arms emanating from a calixarene core, initiators therefor, and method for the synthesis thereof

What is claimed is: 1. A composition of matter comprising: a core component selected from the group ...

High molecular weight polymer-based prodrugs

The present invention addresses the shortcomings described above. In one aspect of the invention, ...

Non-antigenic branched polymer conjugates

OF THE INVENTION 1. POLYMER SUBSTITUENTS AND FORMULA (I) DEFINED The activated branched polymers ...

Substantially pure histidine-linked protein polymer conjugates

In one aspect, the present invention includes substantially pure protein-polymer conjugates. The ...

Process for synthesizing macrocyclic chelates

Details

Inventors: Gansow, Otto A.; Kumar, Krishan;
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Primary Examiner: Springer; David B.
Assistant Examiner:
Attorney, Agent or Firm: Jain; Mishrilal

A process for synthesizing a 12 membered ring tetraaza macromolecule comprising. The process involves condensing an amide of ethylene diamine having a general formula A: ##STR1## wherein n is an integer from 1 to 5 and w is a member selected from the group consisting of --NO.sub.2, --NH.sub.2, --NCS, --COOH, --OCH.sub.2 OOCH.sub.3, --NCOCH.sub.2 --Z with Z being a member selected from the group consisting of Br and I with a nitrogen blocked active ester of a general formula B: ##STR2## wherein PG is an amino protecting group and E is a leaving group.

DETAILED DESCRIPTION The invention is a process for synthesizing a 12 membered ring tetraaza macromolecule.
The process involves condensing an amide of ethylene diamine having a general formula A: ##STR3## with a nitrogen blocked active ester of a general formula B: ##STR4## The process synthesizes a compound having a general formula I: ##STR5## wherein R.
sub.
1-4H is --CH.
sub.
2 COOH; n is 1 to 5; X is a member selected from the group consisting of --NO.
sub.
2, --NH.
sub.
2, --NCS, --NCOCH.
sub.
2 --Z with Z being a member selected from the group consisting of Br and I --COOH; --OCH.
sub.
2 OOCH.
sub.
3 and M is a metal ion being a member selected from the group of elements consisting of Bi, Pb, Y, Cd, Hg, Al, Th, Sr, and Lanthanides.

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