Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient

DETAILED DESCRIPTION We claim: 1.
A pyrrolo[2,3-d]pyrimidine derivative represented by the general formula I: ##STR218## wherein R.
sup.
1 represents a hydrogen atom, or an unsubstituted or substituted alkyl, alkenyl or arylalkyl group; R.
sup.
2 and R.
sup.
3 independently of each other represent a hydrogen atom, or an unsubstituted or substituted alkyl, alkenyl, arylalkyl or alkycarbonyl group; or R.
sup.
2 and R.
sup.
3 are optionally taken together with the adjacent nitrogen atom to form an unsubstituted saturated 5- to 7- member ring, which may be constructed with one or two hereto atoms selected from the group consisting of N, O and S; R.
sup.
4 and R.
sup.
5 independently of each other represent a hydrogen atom, halogen atom, or an unsubstituted or substituted alkyl group; Y is a linking group bonded to the pyrimidine ring via a nitrogen atom therein of the formula: ##STR219## wherein G represents a hydrogen atom or an alkyl group; Z represents a group bonded to a carbon or nitrogen atom in the linking group, and is a hydrogen atom, an unsubstituted or substituted alkyl, alkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, arylalkylcarbonyl, heteroarylalkylcarbonyl, alkyloxycarbonyl, alkylcarbonyloxy, arylcarbonyloxy, arylalkylcarbonyloxy, heteroarylalkylcarbonyl, alkyloxy or alkyloxyimino-alkyl group; or mono- or di-alkylamino, mono- or di-alkylcarbonylamino or N-alkyl-N-alkylcarbonylamino group; or represents a group bonded to a carbon atom in the linking group, and is a carboxyl or hydroxyl group; or Y and Z are taken together to form morpholino or thiomorpholino group; each substituent in said substituted group is substituted at a chain or cyclic moiety of the alkyl, alkenyl, arylalkyl, heteroarylalkyl, aryl, or heteroaryl moiety, respectively, and represents an alkyl, alkyloxy, alkylcarbonyl, alkylcarbonyloxy, hydroxy, mono- or di-alkylamino, amino, nitro, cyano group, or a halogen atom, wherein the heteroaryl groups represent respectively a group selected from the group consisting of pyrrolyl, furyl, thienyl, and pyridyl, with a proviso that R