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Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof
| Details |
Inventors: Staas, Jay K.; Tice, Thomas R.; Raychaudhuri, Syamal; Sleath, Paul R.;
Assignee: Southern Research Institute (Birmingham, AL); Corixa Corporation (Seattle, WA)
Primary Examiner: Azpuru; Carlos A.
Assistant Examiner:
Attorney, Agent or Firm: Needle & Rosenberg, P.C.
A composition for inducing or potentiating an immune response, preferably a CTL, T helper cell, or neutralizing antibody response in a subject, comprising an antigen and/or a non-antigen bioactive agent capable of inducing or potentiating such an immune response encapsulated in a polymeric composition, wherein the polymeric composition comprises a blend of (a) a polymer present in an amount sufficient to provide structural integrity to the polymeric composition, and (b) a rapidly biodegradable component, a rapidly dissolving component, a rapidly swelling component, or a component that causes osmotic rupture of the encapsulated polymeric composition is disclosed. Single polymer compositions for achieving such an immune response are also disclosed. Methods for inducing or potentiating a CTL, T helper cell or neutralizing antibody response using the above-identified compositions are disclosed. |
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DETAILED DESCRIPTION The present invention provides bioactive agents encapsulated in a rapidly releasing polymeric composition capable of inducing or potentiating an immune response and methods for their use.
In accordance with the purpose(s) of this invention, as embodied and broadly described herein, this invention, in one aspect, relates to a composition for inducing a CTL response in a subject, comprising an antigen or a nucleic acid encoding the antigen, encapsulated in a polymeric composition, wherein the polymeric composition comprises a blend of (a) a polymer present in an amount sufficient to provide structural integrity to the polymeric composition, and (b) a component selected from the group consisting of a rapidly biodegradable component, a rapidly dissolving component, a rapidly swelling component, and a component that causes osmotic rupture of the encapsulated polymeric composition.
The polymeric composition can further provide kinetics of antigen or nucleic acid release such that a CTL response is measurable within fourteen days of a single administration at a level of at least 30% cytotoxicity.
The composition can further comprise a non-antigen bioactive agent capable of inducing or potentiating an immune response, or in particular, a CTL response.
The non-antigen bioactive agent can be encapsulated in the polymeric composition or the non-antigen bioactive agent can be present in the composition unencapsulated.
The present invention also provides a composition for inducing a T helper cell response in a subject, comprising an antigen or a nucleic acid encoding the antigen, encapsulated in a polymeric composition, wherein the polymeric composition comprises a blend of (a) a polymer present in an amount sufficient to provide structural integrity to the polymeric composition, and (b) a component selected from the group consisting of a rapidly biodegradable component, a rapidly dissolving component, a rapidly swelling component, and a component that causes osmotic rupture of the encapsulated polymeric composition
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