DETAILED DESCRIPTION OF THE INVENTION In a general aspect, the present invention provides a method of inhibiting the growth of a cancerous cell, comprising contacting the interior of the cell with an effective amount of a RhoB protein or a variant thereof.
The formulations and methods of the present invention can be administered to treat a number of cancers, including but not limited to leukemias and lymphomas such as acute lymphocytic leukemia, acute nonlymphocytic leukemias, chronic lymphocytic leukemia, chronic myelogenous leukemia, Hodgkin's Disease, non-Hodgkin's lymphomas, and multiple myeloma, childhood solid tumors such as brain tumors, neuroblastoma, retinoblastoma, Wilms'Tumor, bone tumors, and soft-tissue sarcomas, common solid tumors of adults such as lung cancer, colon and rectum cancer, breast cancer, prostate cancer, urinary cancers, uterine cancers, oral cancers, pancreatic cancer, melanoma and other skin cancers, stomach cancer, ovarian cancer, brain tumors, liver cancer, laryngeal cancer, thyroid cancer, esophageal cancer, and testicular cancer.
The method of the present invention is particularly applicable in the treatment of pancreatic tumors and lung cancer.
The method of the present invention can be practiced on mammals, particularly humans.
The term "RhoB protein or a variant thereof" denotes RhoB-F, RhoB-GG and RhoB-WT proteins and any variants thereof that may be derived from RhoB-F, RhoB-GG or RhoB-WT as variants possessing at least one characteristic biological activity of RhoB, derived, for example, from the aforementioned proteins by truncation, oxidation, amino acid substitution, post-translational modification, labeling, or by linkage to another molecule.
In another embodiment, the invention provides a method of suppressing malignant transformation of a cell.
In this embodiment, RhoB or a variant thereof a composition comprising RhoB, a variant of RhoB, or a pharmaceutically acceptable salt thereof is administered to a cell capable of malignant transformation, thereby preventing transformation
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Gene Therapy 
