Solid phase dispersion of quinolone or naphthyridonecarboxylic acids

DETAILED DESCRIPTION What is claimed is: 1.
A solid phase dispersion comprising a micronized quinolinecarboxylic acid or micronized naphthyridonecarboxylic acid in an insoluble matrix, wherein the insoluble matrix is shellac and wherein the particle size of the solid dispersion is about 20 to about 100 mesh size.
2.
The dispersion of claim 1, wherein quinolinecarboxylic acid or naphthyridonecarboxylic acid and the insoluble matrix are in a ratio of 1:0.
5 to 10.
3.
The dispersion of claim 2, wherein quinolinecarboxylic acid or naphthyridonecarboxylic acid and the insoluble matrix are in a ratio of 1:5.
4.
A method of preparing a solid dispersion of a quinolinecarboxylic acid or naphthyridonecarboxylic acid, comprising forming a hydrate of micronized quinolinecarboxylic acid or micronized naphthyridonecarboxylic acid, mixing the quinolinecarboxylic acid or naphthyridonecarboxylic acid with an insoluble matrix, wherein the soluble matrix is shellac, heating the mixture until it flows, and micronizing the mixture to reduce particle size, wherein said particle size is about 20 to about 100 mesh size.
5.
A feed formulation comprising feedstuff and the solid phase dispersion of claim 1.
6.
A process for improving animal uptake of quinolinecarboxylic acid or naphthyridonecarboxylic acid comprising orally administering to the animal a solid phase dispersion of claim 1 in an effective amount to mask the taste of the active agent.




Description:
FIELD OF THE INVENTION The present invention relates to the preparation of orally administrable formulations of quinolone- or naphthyridonecarboxylic acids and methods of making and using the same.
More specifically, the invention relates to quinolone- or naphthyridonecarboxylic acids in a solid phase dispersion, which masks their bitter taste.
BRIEF DESCRIPTION OF THE PRIOR ART Quinolonecarboxylic acids and their formulations are already known.
See, for example, EP-A (European Published Specification) 238 814.
Of particular interest here are formulations that are intended to mask the bitter taste of the active quinolone compounds