Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus

DETAILED DESCRIPTION OF THE INVENTION A.
Definitions Amino Acid Residue: An amino acid formed upon chemical digestion (hydrolysis) of a polypeptide at its peptide linkages.
The amino acid residues described herein are preferably in the "L" isomeric form.
However, residues in the "D" isomeric form can be substituted for any L-amino acid residue, as long as the desired functional property is retained by the polypeptide.
NH.
sub.
2 refers to the free amino group present at the amino terminus of a polypeptide.
COOH refers to the free carboxy group present at the carboxy terminus of a polypeptide.
In keeping with standard polypeptide nomenclature (described in J.
Biol.
Chem.
, 243:3552-59 (1969) and adopted at 37 CFR .
sctn.
1.
822(b)(2)), abbreviations for amino acid residues are shown in the following Table of Correspondence:
TABLE OF CORRESPONDENCE
SYMBOL
1-Letter 3-Letter AMINO ACID
Y Tyr tyrosine
G Gly glycine
F Phe phenylalanine
M Met methionine
A Ala alanine
S Ser serine
I Ile isoleucine
L Leu leucine
T Thr threonine
V Val valine
P Pro proline
K Lys lysine
H His histidine
Q Gln glutamine
E Glu glutamic acid
Z Glx Glu and/or Gln
W Trp tryptophan
R Arg arginine
D Asp aspartic acid
N Asn asparagine
B Asx Asn and/or Asp
C Cys cysteine
X Xaa Unknown or other
It should be noted that all amino acid residue sequences represented herein by formulae have a left-to-right orientation in the conventional direction of amino terminus to carboxy terminus