Home | Links | Contact Us | More About Intellectual Property | Bookmark
Search patents:
Home Gene Therapy Tricyclic-macrolide-antibacterial-compounds

 Liposomes containing oligonucleotides
What we claim is: 1. A composition comprising cationic liposomes which consist essentially of ...


 Protonated/acidified nucleic acids and methods of use
OF THE PREFERRED EMBODIMENTS It is to be understood that this invention is not limited to the ...


 Oligonucleotide derivatives
What is claimed is: 1. A compound which is selected from the group consisting of the base ...


 Crystal forms of azithromycin
The present invention relates to crystal forms of azithromycin. As used herein, the term "crystal ...


 Method for delivering melanin to hair follicles
It has now been discovered that liposomes can selectively target the hair follicle with potentially ...


 Human G-protein coupled receptor
What is claimed is: 1. An isolated polynucleotide comprising a nucleotide sequence chosen from: a) ...


 Use of a polysaccharide excreted by the Vibrio diabolicus species in bone repair
The invention claimed is: 1. A bone reconstruction biomaterial, comprising a polysaccharide ...


 Composition for treatment of and method of monitoring hepatitis C virus using interferon-TAU
OF THE INVENTION I. Definitions Hepatitis C virus or HCV refers to the viral species of which ...


 Anti-viral guanosine-rich oligonucleotides
In one embodiment of the present invention, there is provided a method of treating a ...


 Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage
OF THE PREFERRED EMBODIMENTS The present invention is predicated in part on a base specific ...


 Tricyclic macrolide antibacterial compounds

Details
Inventors: Gu, Yu-Gui; Ma, Zhenkun; Yong, Hong;
Assignee:
Primary Examiner: Peselev; Elli
Assistant Examiner:
Attorney, Agent or Firm: Donner; B. Gregory

Antibacterial compounds having formula (I) ##STR00001## and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

DETAILED DESCRIPTION OF THE INVENTION Compounds of this invention, also referred to as "the compounds," comprise both fixed and variable moieties, which variable moieties are identified by a capital letter and accompanying numerical and/or alphabetical superscript, and for which the following terms have the meanings indicated.
"Alkenyl" means monovalent, straight-chain and branched-chain hydrocarbon moieties, having two to eight carbon atoms and at least one carbon-carbon double bond, attached through a carbon atom.
Examples of alkenyl moieties include but-1,3-dienyl, butenyl, but-2-enyl, ethenyl, 1-ethylhexen-2-yl, hex-3-enyl, 1-methylbutenyl, 2-methylbutenyl, 1-methylbut-2-enyl, 1-methylbut-1,3-dienyl, pentenyl, pent-2-enyl, pent-3-enyl, and propenyl.
"Alkyl" means monovalent, saturated, straight-chain and branched-chain hydrocarbon moieties, having one to six carbon atoms, attached through a carbon atom.
Examples of alkyl moieties include butyl, 1,1, -dimethylethyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, ethyl, 1-ethylpropyl, 2-ethylpropyl, hexyl, methyl, 2-methylpropyl, 3-methylbutyl, 1-methylpentyl, 2-methylpent-3-yl, and pentyl.
"Alkylene" means divalent, saturated, straight-chain and branched-chain hydrocarbon moieties, having one to eight carbon atoms, attached through carbon atoms.
Examples of alkylene moieties include butylene, 1,1,-dimethylethylene, 1,1-dimethylpropylene, 1,2-dimethylpropylene, ethylene, 1-ethylpropylene, 2-ethylpropylene, hexylene, methylene, 2-methylpropylene, 3-methylbutylene, 1-methylpentylene, 2-methyl-2-ethylpropylene, and pentylene.
"Alkynyl" means monovalent, straight-chain and branched-chain hydrocarbon moieties, having two to six carbon atoms and at least one carbon-carbon triple bond, attached through a carbon atom.
Examples of alkynyl moieties include ethynyl (acetylenyl), pentynyl, pent-2-ynyl, pent-3-ynyl, pent-4-ynyl, 1-methylbut-2-ynyl, 2-methylbut-3-ynyl, hexynyl, hex-2-ynyl, hex-3-ynyl, hex-4-ynyl, 1-methyl-pent-2-ynyl, 1-methylenepent-3-ynyl, 1-methyl-pent-2,4-diynyl, and prop-2-ynyl (propargyl)



Related patents
  Gene encoding MNR2 and uses thereof
OF THE INVENTION The following standard abbreviations are used throughout the specification to indicate specific nucleotides: C=cytosine A=adenosine T=thymidine G=...
  Polyene microlide pre-liposomal powders
OF THE PREFERRED EMBODIMENT A stable powder suitable for the direct preparation of liposome-incorporated antifungal polyene macrolides may be made by a process of the ...
  Process for stabilizing liposomes
We claim: 1. A process for stabilizing liposomes comprising: a) first forming liposomes by hydrating a lipid film with an aqueous solution containing less than 10 mM of ...
  cDNA encoding human phospholipase A.sub.2 polypeptide
OF THE INVENTION The present invention provides a novel intracellular human phospholipase A.sub.2 that employs a catalytic strategy distinct from that utilized by ...
  DNA encoding Bcl-2-associated proteins
The present invention relates to a nucleic acid molecule encoding a protein or a fragment thereof that associates with Bcl-2 or a Bcl-2-related protein. The invention ...
  Hybridoma-producing NSO myeloma cell line
This invention is directed to NSO.sup.bcl-2 myeloma cells and to methods of producing said cells. The NSO.sup.bcl-2 myeloma cells of the invention have high fusion ...
  Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
OF THE PREFERRED EMBODIMENTS The present invention provides an improved method for the encapsulation of high molecular weight nucleic acids in liposomes, wherein a ...
  Bax inhibitor proteins
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor proteins, including Bax inhibitor protein-1 (BI-1) and Bax inhibitor ...
  Phosphonomonoester nucleic acids, process for their preparation, and their use
What is claimed is: 1. A compound of formula I ##STR37## in which n is a number from zero to 100; A independently of one another is a single bond, a methylene group or a ...
  Oligonucleotide phosphate esters
OF THE PREFERRED EMBODIMENTS The present invention provides oligonucleotide analogs characterized by having at least one internucleotide phosphate bond modified as ...

0.004

Archive: All patents - Links

Copyright (c)2006 Eipa-patents.org - All rights reserved