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Use of a polysaccharide excreted by the Vibrio diabolicus species in bone repair
| Details |
Inventors: Guezennec, Jean; Zanchetta, Philippe;
Assignee: Institut Francais de le Recherche pour l'Exploitation de la Mer (Issey les Moulineaux, FR)
Primary Examiner: Wilson; James O.
Assistant Examiner: Khare; Devesh
Attorney, Agent or Firm: Young & Thompson
The invention concerns the use of a polysaccharide excreted by the Vibrio diabolicus species for making a medicine with cicatrising activity, in particular bone repair activity. The invention also concerns a bone reconstruction biomaterial comprising said polysaccharide and a bone endoprosthesis whereof the surface is coated with such a polysaccharide. |
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DETAILED DESCRIPTION The invention claimed is: 1.
A bone reconstruction biomaterial, comprising a polysaccharide excreted by the Vibrio diabolicus species having cicatrizing activity, and at least one of an osteoconductive or osteoinductive filler material.
2.
A bone endoprosthesis at least partially coated with a polysaccharide excreted by the Vibrio diabolicus species having cicatrizing activity.
3.
A method for cicatrizing bone comprising: administering to a subject in need thereof a polysaccharide excreted by the Vibrio diabolicus species to said bone in an amount effective for cicatrizing the bone.
4.
The method of claim 3, wherein the polysaccharide is administered in an amount effective for repairing the bone.
5.
The method of claim 3, further comprising coating a bone endoprosthesis with the polysaccharide.
6.
The method of claim 3, further comprising administering an osteoconductive filling material to bone.
7.
The method of claim 3, wherein the polysaccharide is obtained by precipitation with ethanol from culture supernatants of the Vibrio diabolicus species.
8.
The method of claim 3, wherein the polysaccharide does not comprise any neutral polysaccharides, has an acid saccharide content of 50% by weight, has an osamine content of 50% by weight, and has a glucoronic acid/N-acetylgalactosamine/N-acetylglucosamine monosaccharide molar ratio of 2/1/1.
9.
The method of claim 3, wherein the polysaccharide is present in a composition at least one of an osteoconductive or osteoinductive filler material.
10.
The methos of claim 9, comprising administering a composition comprising an osteoconductive material selected from the group consisting of a deproteinized bone, deceramized bolne, a synthetic calcium phosphate, a natural calcium phophate, biovitroceramic and a bioglass.
Description:
The present invention relates to the use of a polysaccharide excreted by the Vibrio diabolicus species for producing a medicinal product with cicatrizing activity, and also to a bone reconstruction biomaterial comprising this polysaccharide
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Gene Therapy 
