|
WF11243 substance
| Details |
Inventors: Fujie, Akihiko; Takase, Shigehiro; Yamashita, Michio; Sato, Tomoko; Hashimoto, Seiji; Okuhara, Masakuni;
Assignee: Fujisawa Pharmaceutical Co., Ltd. (Osaka, JP)
Primary Examiner: Lilling; Herbert J.
Assistant Examiner:
Attorney, Agent or Firm: Oblon, Spivak, McClelland, Maier & Neustadt
The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects. |
|
DETAILED DESCRIPTION We claim: 1.
An isolated compound having formula (I): ##STR4## or a salt thereof.
2.
A method for producing a compound of formula (I): ##STR5## or a salt thereof which comprises: culturing FERM BP-3373 in a medium and collecting the compound of formula (I) or a salt thereof.
3.
A purified cell culture containing a microorganism which produces a compound of formula (I): ##STR6## 4.
The purified cell culture of claim 3, wherein the microorganism is FERM BP-3373.
5.
A fungicide comprising an effective amount of the compound of formula (I) in claim 1 or a salt thereof.
6.
A protozoicide comprising an effective amount of the compound of formula (I) of claim 1 or a salt thereof.
7.
The protozoicide of claim 6, wherein the protozoan is Pneumocystis carinii.
Description:
FIELD OF THE INVENTION The present invention relates to WF11243 substance and its salts as well as to a method of preparing them and use of them.
The WF11243 substance is a novel substance which is isolated and purified from a culture broth of microorganisms, especially fungi.
It has excellent fungicidal and protozoicidal activity and is, therefore, useful as various preventing and treating medicines for preventing, curing and reducing various diseases and disorders to be caused by fungi and protozoans.
It is also useful for prevention and treatment of Pneumocystis carinii pneumonia.
Therefore, the present invention plays an important role in various technical fields of medicines, cosmetics, foods and drinks.
PRIOR ART Hitherto, various fungicides have been obtained from cultures of microorganisms or by chemical syntheses.
Some of them could be admitted to be good, but many of them have various problems, such as appearance of drug-tolerant microoganisms and safety of themselves.
At present, no one has a satisfactory fungicidal agent which is completely free from the problems.
Recently, various diseases to be caused by protozoans, especially those to be caused by Pneumocystis carinii such as Pneumocystis carinii pneumonia, have been closed up, and development of methods of preventing and treating them has been strongly desired in this technical field
|
| Related patents |
|
|
Plant virus vector, plasmid, process for expression of foreign gene and process for obtaining foreign gene product
The purpose of the present invention is to provide plant virus vectors having the ability to systemically infect a whole plant; plasmids, which are transcribed to ...
|
|
|
Electrophoretic method for the isolation and separation of microorganisms and cell populations
It is an object of the invention to provide a novel electrophoretic method for the separation of viable mixtures of viable bacteria for analysis of microbial communities....
|
|
|
Human antithrombin III
The present invention is directed to the means and methods of producting human antithrombin III via recombinant DNA technology, including (1) the discovery and identity ...
|
|
|
Cryptophycins
OF THE INVENTION The present invention provides novel cryptophycin compounds having the following structure: ##STR4## Wherein R.sub.1 is H, OH, a halogen, O of a ketone ...
|
|
|
Method for recovery of refined .alpha.-galactosidase
OF THE INVENTION The methods heretofore suggested for the refinement of .alpha.-galactosidase suffer from various disadvantages such as poor recovery ratio, ...
|
|
|
Antimicrobial composition containing Type II endoglycosidase and antimicrobial agent
The invention provides antimicrobial methods utilizing Type II endoglycosidases such as endo-.beta.-N-acetylglucosaminidase ("Endo") H, D, F and/or PNGase F alone or in ...
|
|
|
Wound healing composition of IGF-I and TGF-.beta.
We claim: 1. A method for healing an external wound of a mammal comprising applying to said wound a wound-healing amount of a composition consisting essentially or ...
|
|
|
Flowable demineralized bone powder composition and its use in bone repair
What is claimed is: 1. A flowable composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth-inducing ...
|
|
|
Crosslinkable polypeptide compositions
OF THE INVENTION In accordance with the present invention, there are provided chemically modified polypeptides having the formula: P--(A--C(O)--Y).sub.n wherein: P is ...
|
|
|
Gene Therapy 
