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 Wound and skin care compositions

Details
Inventors: Malik, Sohail;
Assignee: Kimberly-Clark Worldwide, Inc. (Neenah, WI)
Primary Examiner: Peselev; Elli
Assistant Examiner:
Attorney, Agent or Firm: Dority & Manning, P.A.

The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.

DETAILED DESCRIPTION What is claimed: 1.
A composition comprising a dermatologically acceptable carrier and an effective amount of a hydroxy acid compound, present in a concentration of about 10.
sup.
-4 M to about 10.
sup.
-6 M, wherein the composition can stimulate cellular proliferation of mammalian fibroblasts or keratinocytes, and wherein the hydroxy acid compound is salicylic acid or acetylsalicylic.
2.
The composition of claim 1, wherein the composition further comprises an effective amount of a jasmonic acid compound, a gibberellic acid compound or a zeatin compound.
3.
The composition of claim 2, wherein the jasmonic acid compound is a compound of any one of formulae VI IX: ##STR00012## wherein: R3 is alkyl; R4 is COOR, or --(CH.
sub.
2).
sub.
n--OX, where n is an integer of from 1 to 20; R is H, or alkyl; X is H, or 1 to 6 hexose or pentose residues; and Y is H, alkyl, or 1 to 6 hexose or pentose residues.
4.
The composition of claim 2, wherein the jasmonic acid compound is jasmonic acid, hydroxyjasmonic acid, dihydrojasmonic acid, or dihydro-hydroxyjasmonic acid.
5.
The composition of claim 2, wherein the zeatin compound is a compound of formula X: ##STR00013## wherein: R5 is H, 3-hydroxymethl-3-methylallyl, alkyl, --(CH.
sub.
2).
sub.
n--CH.
sub.
3, or OZ; Z is H, 1 to 6 sugar residues, or --(CH.
sub.
2).
sub.
n-furan; R6 is H, 3-hydroxymethl-3-methylallyl, alkyl, --(CH.
sub.
2).
sub.
n--CH.
sub.
3, or OZ; and n is an integer of 1to 20.
6.
The composition of claim 2, wherein the zeatin compound is zeatin.
7.
The composition of claim 1, further comprising one or more additional skin care or gum care active ingredients.
8.
The composition of claim 7, wherein the additional ingredient is a desquamation compound, an anti-acne compound, an anti-wrinkle compound, a vitamin B.
sub.
3 compound, a vitamin E compound, a retinoid compound, a hydroxy acid compound, an anti-oxidant compound, a radical scavenger, a chelating agent, a flavonoid compound, an anti-inflammatory agent, an anti-cellulite agent, a topical anesthetic, a tanning compound, a skin lightening agent, a skin healing compound, an antimicrobial compound, an antifungal compound, a sunscreen compound, a particulate material, a moisturizer, or a thickening agent



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