Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides

DETAILED DESCRIPTION What is claimed is: 1.
A compound having the formula I: ##STR5## wherein, R.
sub.
1 is OH, O--R.
sub.
3, C--R.
sub.
3, halo, NHR.
sub.
4, ONHR.
sub.
5 or ON.
dbd.
R.
sub.
6, wherein R.
sub.
3 is independently a moiety selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester; R.
sub.
4 is independently a moiety selected from a group consisting of alkyl (C1-22), acyl (C1-22), substituted or unsubstituted aryl), or OCH.
sub.
2 SCH.
sub.
3 (methylthiomethyl); R.
sub.
5 is independently a moiety selected from a group consisting of H, aminoacyl group, peptidyl group, biotinyl group, cholesteryl group, lipoic acid residue, retinoic acid residue, folic acid residue, ascorbic acid residue, nicotinic acid residue, 6-aminopenicillanic acid residue, 7-aminocephalosporanic acid residue, alky, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide or ester; and R.
sub.
6 is independently pyridoxal residue, pyridoxal-5-phosphate residue, 13-cis-retinal residue, 9-cis-retinal residue, alkyl, alkenyl, alkynyl, alkylaryl, carbocyclic alkylaryl, or heterocyclic alkylaryl; B is independently a nucleotide base or hydrogen; X is independently a phosphorus-containing group; and R.
sub.
2 is independently a blocking group or a phosphorus-containing group.
2.
The compound of claim 1, wherein said compound is a nucleotide.
3.
The compound of claim 1, wherein said compound is a nucleotide-triphosphate.
4.
A polynucleotide comprising the compound of claim 1 at one or more positions.
5.
The polynucleotide of claim 4, wherein said polynucleotide is an enzymatic nucleic acid.
6.
The enzymatic nucleic acid of claim 5, wherein said nucleic acid is in a hammerhead configuration.
7.
The enzymatic nucleic acid of claim 6, where in said nucleic acid is in a hairpin configuration.
8.
The enzymatic nucleic acid of claim 6, wherein said nucleic acid is in a hepatitis delta virus, group I intron, VS RNA, group II intron or RNase P RNA configuration