Rhob as a suppressor of cancer cell growth and cell transformation
OF THE INVENTION In a general aspect, the present invention provides a method of inhibiting the growth of a cancerous cell, comprising contacting the interior of the cell with an effective amount of ... Read More
Inventors: Sebti, Said M.;, Assignee: University of South Florida Board of Trustees (Tampa, FL) |
Pharmacologically acceptable solvent vehicles
One aspect of the present invention is an antifungal composition that is suitable for parenteral administration to a mammal. The composition includes an amount of pimaricin or an antifungal derivative... Read More
Inventors: Andersson, Borje S.; Anaissie, Elias J.;, Assignee: Board of Regents, the University of Texas System (Austin, TX) |
Aqueous fludarabine phosphate composition
OF THE INVENTION The present invention is based on the discovery that an aqueous fludarabine phosphate composition having enhanced stability at elevated temperatures may be prepared by controlling th... Read More
Inventors: Mirejovsky, Dorla; Macdonald, Peter Lindsay;, Assignee: Sicor, Inc. (Irvine, CA) |
Receptor-mediated gene delivery using bacteriophage vectors
In one aspect, the invention provides a method of gene delivery, comprising: contacting a mammalian cell with filamentous phage particles presenting a ligand on their surfaces, wherein a vector within... Read More
Inventors: Larocca, David; Baird, Andrew; Johnson, Wendy;, Assignee: Selective Genetics, Inc. (San Diego, CA) |
Membrane-resident steroid receptors and methods of use thereof
This invention pertains to the discovery that DPR-1 (formerly known as END-2) a putative nuclear hormone receptor (NHR) that, based on gene reporter studies, is expressed in the endoderm throughout th... Read More
Inventors: Rothman, Joel H.; Newman-Smith, Erin; Broitman-Maduro, Gina;, Assignee: The Regents of the University of California (Oakland, CA) |
Process for integration of a chosen gene on the chromosome of a bacterium using Mu transposons
One aim of the invention is to describe a method for amplifying and stably fixing the copies of chosen genes in a microorganism with more flexibility and more reliability than was hitherto possible. T... Read More
Inventors: Richaud, Fran.cedilla.ois; Jarry, Bruno; Takinami, Koichi; Kurahashi, Osamu; Beyou, Anne;, Assignee: Eurolysine (Paris, FR) |
Transposon-based transformation vectors
I claim: 1. A vector for inserting an exogenous gene into a chromosome of a eukaryotic cell, comprising: (a) a gene encoding a bacterial transposase; (b) two transposon insertion sequences recognized ... Read More
Inventors: Cooper, Richard K.;, Assignee: Board of Supervisors of Louisiana State University and Agricultural and (Baton Rouge, LA) |
Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
OF THE INVENTION Definitions Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this in... Read More
Inventors: Whitney, Michael A.;, Assignee: Aurora Biosciences Corporation (San Diego, CA) |
Vectors and methods for providing cells with additional nucleic acid material integrated in the genome of said cells
OF THE INVENTION Tc1 belongs to the Tc1/mariner superfamily of transposons found in nematodes, arthropods and chordates (Henikoff 1992; Raddice et al. 1994; Robertson 1995; Plasterk 1995). Both verti... Read More
Inventors: Plasterk, Ronald Hans Anton; Valerio, Domenico; Schouten, Govert Johan; van Luenen, Hendricus Gerhard Adrianus Maria; Vos, Jan C.;, Assignee: Het Nederlands Kanker Instituut (Amsterdam, NL); IntroGene B.V. (Leiden, NL) |
DNA-based transposon system for the introduction of nucleic acid into DNA of a cell
OF THE PREFERRED EMBODIMENTS The present invention relates to novel tranposases and the transposon that are used to introduce nucleic acid sequences into the DNA of a cell. A transposase is an enzyme... Read More
Inventors: Hackett, Perry B.; Ivics, Zoltan; Izsvak, Zsuzsanna;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Methods for diagnosing sepsis
The present invention provides a pharmaceutical composition for treating conditions (diseases) mediated by the inflammatory cytokine cascade, comprising an effective amount of an antagonist or inhibit... Read More
Inventors: Tracey, Kevin J.; Wang, Haichao;, Assignee: North Shore-Long Island Jewish Research Institute (Great Neck, NY) |
Low aromatics composition
The inventions claimed is: 1. A solvent composition comprising (a) a hydrocarbon component in an amount within the range of 91 99 vol. % of said composition; and (b) an ester component in an amount wi... Read More
Inventors: Vandermeiren, Herman;, Assignee: |
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
The present invention describes a covalently-linked complex (CLC) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the e... Read More
Inventors: Anderson, David C.; Morgan, Jr., A. Charles; Abrams, Paul G.; Fritzberg, Alan R.; Nichols, Everett J.;, Assignee: NeoRx Corporation (Seattle, WA) |
Compositions and methods for drug delivery using pH sensitive molecules
We claim: 1. A process for transfecting a nucleic acid into a cell in vivo, comprising: a) attaching a membrane activity inhibitor to a membrane active peptide via a labile linkage, wherein the inhibi... Read More
Inventors: Wolff, Jon A.; Hagstrom, James E.; Rozema, David B.; Monahan, Sean D.; Budker, Vladimir G.;, Assignee: Mirus Bio Corporation (Madison, WI) |
Chiral peptide nucleic acid monomers and oligomers
What is claimed is: 1. A peptide nucleic acid monomer having the formula: ##STR5## wherein: B is a naturally or non-naturally ocurring nucleobase; n is 0, 1, 2, or 3; and at least one of C.alpha. or C... Read More
Inventors: Nielsen, Peter; Buchardt, deceased, Ole; Buchardt, by Mrs. D.; Lagriffoul, Pierre;, Assignee: |
Enzymatic DNA molecules
The present invention thus contemplates a synthetic or engineered (i.e., non-naturally-occurring) catalytic DNA molecule (or enzymatic DNA molecule) capable of cleaving a substrate nucleic acid (NA) s... Read More
Inventors: Joyce, Gerald F.; Breaker, Ronald R.;, Assignee: The Scripps Research Institute (La Jolla, CA) |
Multigene vectors
The present invention provides a method for preparing HSV vectors. The method comprises co-transfecting a source vector and a mutating cassette together into a population of appropriate host cells, su... Read More
Inventors: Glorioso, Joseph C.; Krisky, David;, Assignee: University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, PA) |
Composition and method for inhibiting platelet aggregation
OF THE INVENTION This invention is provides a method of preventing or treating diseases or conditions associated with platelet aggregation. The method also provides a method of treating thrombosis. T... Read More
Inventors: Boyer, Jose; Douglass, III, James G.; Shaver, Sammy R.; Bednarski, Krzysztof; Yerxa, Benjamin R.; Olins, Gillian M.;, Assignee: Inspire Pharmaceuticals, Inc. (Durham, NC) University of North Carolina (Chapel Hill, NC) |
Nucleic acid probes
OF THE INVENTION "Derivatizable" nucleotides are nucleotides modified so as to include at the 4-position of a pyrimidine a functional group which can react with a detectable label. An example of a de... Read More
Inventors: Urdea, Michael S.; Horn, Thomas;, Assignee: Chiron Corporation (Emeryville, CA) |
Assay for antiviral activity using complex of herpesvirus origin of replication and cellular protein
The drawings are first described. FIG. 1 is a diagram of the HSV-1 genome and oriS. FIG. 1A indicates the locations of the three origins of DNA replication and the locations of the seven essential DN... Read More
Inventors: Schaffer, Priscilla A.; Dabrowski Amaral, Christine E.;, Assignee: Dana-Farber Cancer Institute (Boston, MA) |
Substrate for detection of mammalian 5-C-DNA methyltransferase
OF THE INVENTION "Oligomeric DNA" or ODN, as used herein, means a DNA having from 10 to 75 "purine or pyrimidine bases" connected in a series of nucleotides which are deoxyribonucleotides or analogs ... Read More
Inventors: Sufrin, Janice R.; Christman, Judith K.; Marasco, Jr., Canio J.; Sheikhnejad, Gholamreza;, Assignee: Health Research, Inc. (Buffalo, NY) |
Vinyl ethers of nucleoside analogs
OF THE INVENTION The compounds of the present invention can exist as optical isomers. Both the racemic and diasteromeric mixtures of these isomers which may exist for certain compounds, as well as th... Read More
Inventors: Kim, Choung Un; Martin, John C.; Luh, Bing Uh; Misco, Peter F.;, Assignee: Institute of Organic Chemistry and Biochemistry of the Academy of (CZ); Rega Stichting v.z.w. (BE) |
Nucleoside analogs
OF THE INVENTION The compounds of the present invention can exist as optical isomers. Both the racemic and diasteromeric mixtures of these isomers which may exist for certain compounds, as well as th... Read More
Inventors: Kim, Choung Un; Martin, John C.; Luh, Bing Uh; Misco, Peter F.;, Assignee: Institute of Organic Chemistry and Biochemistry of the Academy of (CZ); Rega Stichting, v.z.w. (BE) |
Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof
To accomplish those objectives, the present invention provides hydrophobic muiticomponent heparin conjugates in which heparin is coupled with macromolecules and hydrophobic materials. The present inv... Read More
Inventors: Byun, Young Ro; Moon, Hyun Tae;, Assignee: Mediplex Corporation, Korea (KR) |
Gas permeable bioreactor and method of use
OF THE PREFERRED EMBODIMENTS Like numbered apparatus elements in FIGS. 1-11 are the same. Referring to the drawings, FIG. 1 is a cross-sectional side view of a preferred embodiment of the gas permeab... Read More
Inventors: Schwarz, Ray P.;, Assignee: Synthecon, Inc. (Houston, TX) |
Method for treating diseases of the inner ear using adamantane derivatives
OF THE INVENTION As already mentioned, the use of adamantane derivatives is possible or conceivable in many cases of diseases of the inner ear. Preferably, adamantane derivatives can be used in the c... Read More
Inventors: Zenner, Hans Peter; Ruppersberg, J. Peter; Busch, Andreas;, Assignee: Tinnitus Forschungs-und Entwicklungs GmbH (Munich, DE) |
Polyalkylene oxide-containing urethane polyols with sulphonic acid groups
What is claimed is: 1. Sulphonic acid group-containing polyalkylene oxide-containing urethane polyols corresponding to the formula: ##STR16## wherein X represents an NH.sub.4 radical or an alkali meta... Read More
Inventors: Engelhard, Helmut; Wolf, Gerhard D.; Bentz, Francis; Nischk, Gunther;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
Herpes treatment
I claim: 1. A method for the control of herpes virus infections in man which comprises contacting the herpes lesions, topically or by injection, with a dose of L-lysine L-glutamate effective to contro... Read More
Inventors: Gerzon, Koert;, Assignee: BetaMED Pharmaceuticals, Inc. (Indianapolis, IN) |
Dense star polymers and dendrimers
OF ILLUSTRATIVE EMBODIMENTS In the dense star polymers of the present invention, the core is covalently bonded to at least one core branch, preferably at least two, most preferably at least three, co... Read More
Inventors: Tomalia, Donald A.; Dewald, James R.;, Assignee: The Dow Chemical Company (Midland, MI) |
Glycerin derivatives and inhibition of blood PAF
OF THE INVENTION The glycerine derivatives of the invention are compounds of the formula ##STR3## wherein one of the residues R.sup.1, R.sup.2 and R.sup.3 is group U of the formula--OY.sup.1 or --X.s... Read More
Inventors: Barner, Richard; Burri, Kasper; Cassal, Jean-Marie; Hadvary, Paul; Hirth, Georges; Muller, Klaus;, Assignee: Hoffman-La Roche Inc. (Nutley, NJ) |
Gene Therapy 
