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Results: 31-60 of 4797
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Oligonucleotide derivatives and production thereof
Gist In view of the state of the art as described above, the present inventors have developed an immobilized oligonucleotide which is useful in purification of nucleic acids and is utilizable for affi... Read More
Inventors: Miyoshi, Kenichi; Fuwa, Toru;, Assignee: Wakunaga Seiyaku Kabushiki Kaisha (Osaka, JP) |
Process for synthesizing macrocyclic chelates
The invention is a process for synthesizing a 12 membered ring tetraaza macromolecule. The process involves condensing an amide of ethylene diamine having a general formula A: ##STR3## with a nitrogen... Read More
Inventors: Gansow, Otto A.; Kumar, Krishan;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
I claim: 1. A method for producing a 1:1 protein:anitbody tioether-linked immunoconjugate as a predominant species, comprising the steps of: combining a protein selected from the group consisting of t... Read More
Inventors: Sivam, Gowsala;, Assignee: NeoRx Corporation (WA) |
Compositions for photodynamic therapy
I claim: 1. A pharmaceutical composition useful for photodynamic therapy which composition contains, as active ingredient, a conjugate of a porphyrin-type photosensitizer with a hydrophilic, water sol... Read More
Inventors: Liu, Daniel;, Assignee: Quadra Logic Technologies Inc. (Vancouver, CA) |
Amplifier molecules for enhancement of diagnosis and therapy
As used herein, an "amplifier" or "amplifier molecule" is a chemical compound having a multiplicity of terminal amine moieties, each serving as a locus to which one or two of any of several desired f... Read More
Inventors: Keana, John F. W.;, Assignee: The State of Oregon Acting by and through the State Board of Higher (Eugene, OR) |
Peptide-containing polyethylene glycol derivatives and application thereof
OF THE PREFERRED EMBODIMENTS The present invention will hereinafter be explained in more detail. The peptide-containing polyethylene glycol derivatives of the present invention are represented by the... Read More
Inventors: Tsukada, Yoshihisa; Orikasa, Atsushi;, Assignee: Fuji Photo Film Co., Ltd. (Kanagawa, JP) |
Modified HIL-6
OF THE INVENTION Described below is the chemical modification with PEG of at least one amino group of polypeptides possessing IL-6 activities. This modification results in an increase in in vivo half... Read More
Inventors: Mikayama, Toshihumi; Kadoya, Toshihiko; Kakitani, Makoto; Inoue, Hideo;, Assignee: Kirin-Amgen, Inc. (Thousand Oaks, CA) |
Construction of geometrical objects from polynucleotides
By means of the present invention, DNA, RNA and similar polymers may be produced by synthesizing a double stranded segment, preferably with a loop at one end, cleaving the end of the double stranded p... Read More
Inventors: Seeman, Nadrian C.; Zhang, Yuwen;, Assignee: New York University (New York, NY) |
Starburst conjugates
In its broadest aspect, the present invention is directed to polymer conjugate materials comprising dense star polymers or starburst polymers associated with desired materials (hereinafter these polym... Read More
Inventors: Tomalia, Donald A.; Kaplan, Donald A.; Kruper, Jr., William J.; Cheng, Roberta C.; Tomlinson, Ian A.; Fazio, Michael J.; Hedstrand, David M.; Wilson, Larry R.;, Assignee: The Dow Chemical Company (Midland, MI) |
Intermediates for providing functional groups on the 5' end of oligonucleotides
We claim: 1. A partially protected alcohol of the formula: ##STR10## wherein Y.sup.1 is selected from dimethoxytrityl, monomethoxytrityl, trityl or pixyl, Y.sup.2 is selected from benzoyl, acetyl, iso... Read More
Inventors: Jones, David S.; Hachmann, John P.; Conrad, Michael J.; Coutts, Stephen; Livingston, Douglas A.;, Assignee: La Jolla Pharmaceutial Company (San Diego, CA) |
Antiviral polynucleotide conjugates
OF THE INVENTION The present invention provides polynucleotide conjugates characterized by the properties of ligand binding and enhanced stability. In the present specification, the term "enhanced st... Read More
Inventors: Climie, Shane; Ma, Michael;, Assignee: Allelix Biopharmaceuticals, Inc. (Missisauga, CA) |
Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles
OF THE PREFERRED EMBODIMENT The azlactone activated polyalkylene oxides of the present invention are preferably prepared from polyalkylene oxides that are soluble in water at room temperature. Polyal... Read More
Inventors: Greenwald, Richard B.;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
INCLUSIVE OF PREFERRED EMBODIMENTS We have discovered that linear block copolymers comprising blocks of poly(alkylene oxide) (PAGs) and peptides attached via --CH.sub.2 CHOHCH.sub.2 N(R)-- based link... Read More
Inventors: Cooper, Eugene R.; Jones, Stephen P.; Pouton, Colin W.; Threadgill, Michael D.;, Assignee: Sterling Winthrop Inc. (New York, NY) |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
The present invention provides for compounds having the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of an N-benzotriazole group, an N-2-pyrrolidinone group, and an 2-oxypyr... Read More
Inventors: Dolence, Eric Kurt; Hu, Chen-Ze; Tsang, Ray; Sanders, Clifton G.; Osaki, Shigemasa;, Assignee: Surface Engineering Technologies, Division of InnerDyne, Inc. (Salt Lake City, UT) |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
OF THE INVENTION The following examples are given to illustrate the invention, but should not be considered in limitation of the invention: Example 1--Synthesis of CH.sub.3 O--(CH.sub.2 CH.sub.2 O).s... Read More
Inventors: Harris, J. Milton; Kozlowski, Antoni;, Assignee: Shearwater Polymers, Inc. (Huntsville, AL) |
Polyoxypropylene/polyoxyethylene copolmers with improved biological activity
Although the prior art preparations of polyoxypropylene/polyoxyethylene block copolymers may have been suitable for industrial uses, it has been determined that the newly discovered uses for the copo... Read More
Inventors: Emanuele, R. Martin; Hunter, Robert L.; Culbreth, Paula H.;, Assignee: CytRx Corporation (Norcross, GA) |
Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides
We claim: 1. A compound of the formula ##STR10## where (a) X.sup.1 is chlorine and X.sup.2 is methyl or RO--, or (b) X.sup.2 is RO-- and X.sup.1 is NR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are indiv... Read More
Inventors: Jones, David S.; Hachmann, John P.; Conrad, Michael J.; Coutts, Stephen; Livingston, Douglas Alan;, Assignee: La Jolla Pharmaceutical Company (San Diego, CA) |
Nucleic acid probes immobilized on polystyrene surfaces
We claim: 1. An article of manufacture for use in a solution phase nucleic acid sandwich hybridization assay comprising a polystyrene surface having a polypeptide adsorbed thereon and a nucleic acid p... Read More
Inventors: Sheridan, Patrick; Chang, Chu-An; Running, Joyce; Urdea, Michael S.;, Assignee: Chiron Corporation (Emeryville, CA) |
Star polymers having multiple polyisobutylene arms emanating from a calixarene core, initiators therefor, and method for the synthesis thereof
What is claimed is: 1. A composition of matter comprising: a core component selected from the group consisting of a p-methoxy cumyl group and a calix?n!arene where n=4 to 16; and N number of arms of p... Read More
Inventors: Kennedy, Joseph P.; Majoros, Istvan J.; Jacob, Sunny;, Assignee: The University of Akron (Akron, OH) |
High molecular weight polymer-based prodrugs
The present invention addresses the shortcomings described above. In one aspect of the invention, compositions of formula (I) are provided: ##STR3## wherein: D is a biologically active moiety; M is X ... Read More
Inventors: Greenwald, Richard B.; Pendri, Annapurna;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Non-antigenic branched polymer conjugates
OF THE INVENTION 1. POLYMER SUBSTITUENTS AND FORMULA (I) DEFINED The activated branched polymers of the present invention are preferably prepared from poly(alkylene oxides) (PAO's) that are water sol... Read More
Inventors: Greenwald, Richard B.; Martinez, Anthony J.;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Substantially pure histidine-linked protein polymer conjugates
In one aspect, the present invention includes substantially pure protein-polymer conjugates. The conjugates include a protein, such as an alpha interferon, covalently conjugated to a polymer, such as ... Read More
Inventors: Lee, Seoju; McNemar, Charles;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Crosslinked polymer compositions and methods for their use
The present invention discloses a crosslinked polymer composition comprising a first synthetic polymer containing two or more nucleophilic groups, and a second synthetic polymer containing two or more... Read More
Inventors: Rhee, Woonza M.; DeLustro, Frank A.; Berg, Richard A.;, Assignee: Cohesion Technologies, Inc. (Palo Alto, CA) |
Conjugation of polypeptides
OF THE INVENTION It is the object of the invention to provide polypeptide conjugates with reduced allergenicity. As described above it is well-known according to prior art to conjugate one or more po... Read More
Inventors: Bisgard-Frantzen, Henrik; Olsen, Arne Agerlin; Prento, Annette;, Assignee: Novo Nordisk A/S (Bagsvaerd, DK) |
High molecular weight polymer-based prodrugs
OF THE INVENTION A. THE PRODRUGS In most aspects of the invention, the prodrug compositions of the present invention contain hydrolyzable linkages between the polymer portion and a biologically activ... Read More
Inventors: Greenwald, Richard B.; Pendri, Annapurna; Zhao, Hong;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Non-antigenic amine derived polymers and polymer conjugates
In one aspect of the invention, there are provided amine-based polymer intermediates having the formula: R--B (I) wherein (R) is a water-soluble, substantially non-antigenic polymer residue and (B) is... Read More
Inventors: Greenwald, Richard B.; Martinez, Anthony; Pendri, Annapurna;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Biodegradable high molecular weight polymeric linkers and their conjugates
The present invention includes compounds of the formula: (D).sub.n --M--(R.sub.1).sub.m (I) wherein (m) and (n) independently selected positive integers, preferably from about 1 to about 6 each; D is ... Read More
Inventors: Greenwald, Richard B.; Martinez, Anthony J.; Choe, Yun H.; Pendri, Annapurna;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Modified polypeptides with high activity and reduced allergenicity
OF THE INVENTION The modified polypeptide of the present invention is represented by the formula: A-B.sub.n containing, as essential components, a enzyme, A, and a plurality, n, of twin polymer moiet... Read More
Inventors: Weisgerber, David J.; Rubingh, Donn N.;, Assignee: The Procter & Gamble Co. (Cincinnati, OH) |
Poly(ethylene glycol) derivatives with proximal reactive groups
OF THE INVENTION The terms "group," "functional group," "moiety," "active moiety," "reactive site," reactive group" and "reactive moiety" are used in the art and herein to refer to distinct, definabl... Read More
Inventors: Harris, J. Milton; Kozlowski, Antoni;, Assignee: Shearwater Corporation (Huntsville, AL) |
Devices for cloaking transplanted cells
A variety of devices can be used to contain or cloak a source of a therapeutic substance, often cells, which source provides the substance to a host or recipient subject. Such devices include implanta... Read More
Inventors: Lanza, Robert P.; Chick, William;, Assignee: Biohybrid Technologies LLC (Shrewsbury, MA) |
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Gene Therapy 
