Gapped 2' modified oligonucleotides
OF THE INVENTION In accordance with the objects of this invention, novel oligonucleotides and macromolecules that, at once, have increased nuclease resistance, increased binding affinity to complemen... Read More
Inventors: Cook, Phillip Dan; Monia, Brett P.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Formazan reactive dyes
The invention claimed is: 1. Compounds of the formula (I): ##STR15## where P and P′ are independently H, C1-4-alkyl, C1-4-alkoxy, —SO3H, Q and Q′ are independently H or —SO3H... Read More
Inventors: Gisler, Markus;, Assignee: Clariant Finance (BVI) Limited (Tortola, VG) |
Product and method for control of obesity
The invention claimed is: 1. A transgenic plant comprising a first exogenous nucleic acid molecule which encodes a peptide corresponding to a mammalian growth hormone fragment and comprising a disulph... Read More
Inventors: Belyea, Christopher Ian; Ng, Frank Man-Woon; Vaughan, Paul;, Assignee: Metabolic Pharmaceuticals Limited (Toorak, AU) |
Alpha-morpholino ribonucleoside derivatives and polymers thereof
OF THE INVENTION The present invention includes a morpholino ribonucleoside derivative having an aldehyde at the 5' position (numbered as shown in FIG. 1) in the alpha orientation. The aldehyde of th... Read More
Inventors: Summerton, James E.; Weller, Dwight D.; Stirchak, Eugene P.;, Assignee: Antivirals Inc. (Corvallis, OR) |
Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
The present invention provides novel multimeric oligonucleotides and their use for the purification of antisense oligonucleotides through complementary base recognition and size exclusion principles. ... Read More
Inventors: Agrawal, Sudhir; Habus, Ivan; Kandimalla, Ekambar R.;, Assignee: Hybridon, Inc. (Milford, MA) |
Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
OF THE INVENTION All diabetics, regardless of their genetic and environmental backgrounds, have in common an apparent lack of insulin or inadequate insulin function. Because transfer of glucose from ... Read More
Inventors: Urbanski, Maud;, Assignee: Janssen Pharmaceutica N.V. (Beerse, BE) |
"Burst-free" sustained release poly-(lactide/glycolide) microspheres
OF THE INVENTION This invention relates to the design of biocompatible and biodegradable microspheres for novel, programmable sustained release of biologically active agents, including polypeptides o... Read More
Inventors: Jevanthi, Ramasubbu; Van Hamont, John E.; Friden, Phil; Reid, Robert H.; Roberts, F. Donald; McQueen, Charles E.; Setterstrom, Jean A.;, Assignee: The United States of America as represented by the Secretary of the Army (Washington, DC) |
Neurospora expression system
What is claimed is: 1. A method of producing a mammalian peptide in a Neurospora fungus host, said method comprising: transforming by DNA uptake Neurospora spheroplasts with (1) a DNA construct compri... Read More
Inventors: Stuart, W. Dorsey; Ivy, John M.; Koo, Kenneth;, Assignee: Hawaii Biotechnology Group, Inc. (Aiea, HI) |
Method of reducing bacterial proliferation
OF THE INVENTION Before the present invention is described, it is to be understood that this invention is not limited to particular embodiments described, as such may, of course, vary. It is also to ... Read More
Inventors: Mahan, Michael J.; Heithoff, Douglas M.; Low, David A.; Sinsheimer, Robert L;, Assignee: Regents of the University of California (Oakland, CA) |
Capillary membrane stabilization and reduction of tissue injury through use of IV biodegradable macromolecules with antioxidants and/or other chemicals
We claim: 1. Method of treating a human subject to prevent leakage of serum proteins from capillary endothelial junctions while simultaneously preventing the harmful effect of free radicals on cellula... Read More
Inventors: Zikria, Bashir; Zikria, Jemal D.;, Assignee: |
Derivatives of monosaccharides as cell adhesion inhibitors
OF THE INVENTION The compounds of the present invention may be prepared by techniques well-known in the art and familiar to the average synthetic organic chemist. In addition, the compounds of the pr... Read More
Inventors: Arora, Sudershan K; Gupta, Jang Bahadur; Joshi, Vishwas D;, Assignee: Ranbaxy Laboratories Limited (New Delhi, IN) |
Recombinant human papillomavirus type 18 vaccine
OF THE INVENTION The present invention is directed to DNA molecules encoding purified human papillomavirus type 18 (HPV type 18; HPV 18 ) and derivatives thereof. Such derivatives include but are not... Read More
Inventors: Joyce, Joseph G.; George, Hugh A.; Hofman, Kathryn J.; Jansen, Kathrin U.; Neeper, Michael P.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Synthetic HPV 16 virus-like particles
A series of synthetic virus-like particles useful in the characterization of human papillomavirus type 16 (HPV16) infection and assays employing the synthetic particles are provided.... Read More
Inventors: Ludmerer, Steven;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation
What is claimed is: 1. An immunogenic composition suitable for administration by injection, which comprises antigenic determinants of at least two papillomavirus proteins selected from the group consi... Read More
Inventors: Whittle, Nigel Richard; Carmichael, Jeremy Paddon; Connor, Stephen Edward; Thompson, Henry Stephen Grammer; Wilson, Mark Jonathan;, Assignee: Cantab Pharmaceuticals Research Limited (Cambridge, GB) |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
Methods of creating neoglycoproteins are provided that increase the cellular uptake of lysosomal enzymes and other glycoproteins by covalently attaching oligosaccharide compositions to oxidized glycan... Read More
Inventors: Zhu, Yunxiang;, Assignee: Genzyme Corporation (Cambridge, MA) |
Recombinant avipox virus and immunological use thereof
What is claimed is: 1. A method for inducing an immunological response in a mammal to a mammalian pathogen, which method comprises inoculating the mammal with a recombinant avipox virus comprising DNA... Read More
Inventors: Paoletti, Enzo;, Assignee: Health Research Inc. (Albany, NY) |
HIV protease inhibitors useful for the treatment of AIDS
OF THE INVENTION AND PREFERRED EMBODIMENTS This invention is concerned with compounds of formula I, combinations thereof, or pharmaceutically acceptable salts thereof, in the inhibition of HIV protea... Read More
Inventors: Vacca, Joseph P.; Dorsey, Bruce D.; Guare, James P.; Holloway, M. Katharine; Hungate, Randall W.; Levin, Rhonda B.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Benzoxazinones as inhibitors of HIV reverse transcriptase
OF THE INVENTION AND PREFERRED EMBODIMENTS This invention is concerned with compounds of formula I, combinations thereof, or pharmaceutically acceptable salts thereof, in the inhibition of HIV revers... Read More
Inventors: Young, Steven D.; Payne, Linda S.; Britcher, Susan F.; Tran, Lekhanh O.; Lumma, Jr., William C.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
HIV protease inhibitors useful for the treatment of AIDS
OF THE INVENTION AND PREFERRED EMBODIMENTS This invention is concerned with compounds of Formula I, combinations thereof, or pharmaceutically acceptable salts thereof, in the inhibition of HIV protea... Read More
Inventors: Coburn, Craig A.; Fraley, Mark E.; Holloway, M. Katharine; Hungate, Randall W.; Prendergast, Kristine;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Continuously operational biological reactor
The present invention comprehends a continuously operable biological reactor for processing animal waste material into environmentally safe, chemically free natural fertilizer and includes a pair of d... Read More
Inventors: Miller, Russell Holt;, Assignee: |
Separating epithelium from stroma in LASEK surgery
A surgical method according to the invention includes application of a solution containing ethanol and a cell culture medium. It has been found in animal studies that when bathed in such a solution f... Read More
Inventors: Azar, Dimitri;, Assignee: Massachusetts Eye & Ear Infirmary (Boston, MA) |
Making a lightly oxidized starch additive by adding a cationic polymer to starch slurry prior to heating the slurry
We claim: 1. An improved process for making gelatinous cationic starch useful in surface sizing and coating of cellulosic materials of the type which comprises forming an aqueous slurry of lightly oxi... Read More
Inventors: Buikema, Peter D.; Aitken, Thomas;, Assignee: Nalco Chemical Company (Oak Brook, IL) |
Glucaric acid monoamides and their use to prepare poly(glucaramides)
OF THE INVENTION The novel alkali metal N-aminohydrocarbyl- and N-aminoheterohydrocarbyl-D-glucaramidates suitable for activation to monomers for the self condensation polymerization process are prep... Read More
Inventors: Kiely, Donald E.; Chen, Liang;, Assignee: |
Process for preparing poly (glucaramides)
OF THE INVENTION The novel alkali metal N-aminohydrocarbyl- and N-aminoheterohydrocarbyl-D-glucaramidates suitable for activation to monomers for the self condensation polymerization process are prep... Read More
Inventors: Kiely, Donald E.; Chen, Liang;, Assignee: |
Sheet supplying apparatus with centrally disposed feeding force
An object of the present invention is to provide a sheet supplying apparatus which can surely separate and supply sheets one by one without causing the skew-feed of sheet regardless of a condition of ... Read More
Inventors: Nakagawa, Tomohito; Ueda, Noriyoshi;, Assignee: Canon Kabushiki Kaisha (Tokyo, JP) |
High efficiency retroviral vector which contains genetically engineered cellular non-coding sequence harboring splicing acceptor
The objective of the present invention is to provide a safe and highly efficient retroviral vector that is devoid of the risk of RCR production and still capable of expressing a foreign gene efficient... Read More
Inventors: Kim, Sun-Young; Yu, Seung-Shin; Lee, Jun-Tae;, Assignee: ViroMed Co., Ltd. (KR) |
Nucleic acid probes and amplification oligonucleotides for Neisseria species
OF THE INVENTION A. Definitions The following terms have the indicated meanings in the specification unless expressly indicated to have a different meaning. By "target nucleic acid" is meant a nuclei... Read More
Inventors: Yang, Yeasing; Bee, Gary; McDonough, Sherrol;, Assignee: Gen-Probe Incorporated (San Diego, CA) |
Site-specific protein modification
OF THE INVENTION Site specific modification of proteins and peptides provides a powerful research tool in chemistry and biology. The present invention relates to site-specific modified proteins and m... Read More
Inventors: Rana, Tariq M.; Tamilarasu, Natarajan;, Assignee: University of Medicine and Dentistry of New Jersey (New Brunswick, NJ) |
Nucleic acid encoding gamma retinoic acid receptor fusion protein
What is claimed is: 1. A nucleic acid encoding a chimeric receptor having an N-terminus domain, a DNA-binding domain, and a ligand-binding domain, wherein the N-terminus domain of said chimeric recept... Read More
Inventors: Takaku, Fumimaro; Ishikawa, Takashi; Imawari, Michio; Evans, Ronald Mark; Umesono, Kazuhiko;, Assignee: The Salk Institute for Biological Studies (La Jolla, CA); Sloan-Kettering Institute for Caneer Research (New York, NY) |
Method for specifically altering the nucleotide sequence of RNA
OF THE INVENTION The following words and phrases are defined, for reference in describing the invention, as follows: 1. RNA editing: refers to a specific alteration of the nucleotide sequence of an R... Read More
Inventors: Taylor, John;, Assignee: Fox Chase Cancer Center (Philadelphia, PA) |
Gene Therapy 
