Method and marker for identification of pre-malignancy and malignancy and therapeutic intervention
OF THE INVENTION The present invention provides a method of identifying pre-malignant and malignant cells in cells and tissues. For example the present invention allows identification of micrometasta... Read More
Inventors: Mai, Sabine;, Assignee: University of Manitoba (Winnipeg, CA); Cancercare Manitoba (Winnipeg, CA) |
c-IAP1 and c-IAP2: inhibitors of apoptosis
OF THE INVENTION The invention provides methods and compositions relating to novel cellular inhibitor of apoptosis proteins (c-IAPs). The nucleotide sequence of a natural cDNA encoding human c-IAP is... Read More
Inventors: Rothe, Mike; Goeddel, David V.;, Assignee: Tularik Inc. (South San Francisco, CA) |
Cephalosporin compound and process for preparing the same
What is claimed is: 1. A cephalosporin compound selected from the group consisting of a (Z) isomer of a compound of the formula: ##STR20## wherein R.sup.1 is methyl or tetrazolylmethyl and R.sup.2 and... Read More
Inventors: Wagatsuma, Mitsuyoshi; Hatsuno, Susumu; Yamaguchi, Totaro; Ohshima, Satoshi;, Assignee: Tanabe Seiyaku Co., Ltd. (Osaka, JP) |
L-654,040, antibacterial agent
OF THE INVENTION Antibacterial L-654,040 is obtained by growing under controlled conditions the microorganism Streptoverticillium synroense MA6011, ATCC 53699 in a fermentation broth. The fermentatio... Read More
Inventors: Currie, Sara A.; Miller, Thomas W.; Dulaney, Eugene L.; Springer, James P.; Valiant, Mary E.; Mochales del Val, Sagrario; Zimmerman, Sheldon B.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments
The invention provides compounds including peptides and peptidomimetics that inhibit cell proliferation. The invention compounds are therefore useful for treating cell proliferative disorders or phys... Read More
Inventors: Kawabe, Takumi; Kobayashi, Hidetaka;, Assignee: CanBas Co., Ltd. (Numazu, JP) |
Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
The present invention includes a process of transfecting a polynucleotide into a cell for expression by associating a selected cell with an amphipathic compound, an effective amount of a polynucleoti... Read More
Inventors: Wolff, Jon A.; Fritz, Jeffery; Budker, Vladimir; Hagstrom, James;, Assignee: Mirus Corporation (Madison, WI) |
Compositions for the introduction of polyanionic materials into cells
The present invention provides compositions and methods which are useful for the introduction of polyanionic materials into cells. The compositions are mixtures of cationic compounds and neutral lipid... Read More
Inventors: Ansell, Steven Michial; Mui, Barbara; Hope, Michael;, Assignee: Inex Pharmaceuticals Corp. (CA) |
Highly packed polycationic ammonium, sulfonium and phosphonium lipids
OF THE INVENTION The present invention provides novel, highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds having unique properties and advantages not heretofore available ... Read More
Inventors: Haces, Alberto; Ciccarone, Valentina C.;, Assignee: Life Technologies, Inc. (Gaithersburg, MD) |
Method for the liposomal delivery of nucleic acids
The present invention relates to a nucleic acid-liposome preparation, useful in delivery of nucleic acid-based materials to cells. The present invention further relates to a method of preparing the nu... Read More
Inventors: Thierry, Alain;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Highly packed polycationic ammonium, sulfonium and phosphonium lipids
OF THE INVENTION The present invention provides novel, highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds having unique properties and advantages not heretofore available ... Read More
Inventors: Haces, Alberto; Ciccarone, Valentina C.;, Assignee: Life Technologies, Inc. (Rockville, MD) |
N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
According to a first aspect of the invention, the compounds of this invention are illustrated by Formula (I): ##STR2## or an optical isomer thereof, wherein R.sup.1 and R.sup.2 are independently an al... Read More
Inventors: Eppstein, Deborah A.; Felgner, Philip L.; Gadek, Thomas R.; Jones, Gordon H.; Roman, Richard B.;, Assignee: |
Low stress conformal coatings of reliability without hermeticity for microelectromechanical system based multichip module encapsulation
The present invention overcomes the limitations of existing technology and addresses the needs therein by providing low stress conformal coatings. In one aspect of the invention, low stress conformal ... Read More
Inventors: Wong, Ching Ping; Wu, Jiali;, Assignee: Georgia Tech Research Corp. (Atlanta, GA) |
Nucleic acids encoding JTT-1 protein
What is claimed is: 1. An isolated nucleic acid comprising a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2. 2. The nucleic acid of claim 1, wherein t... Read More
Inventors: Tamatani, Takuya; Tezuka, Katsunari;, Assignee: Japan Tobacco, Inc. (Tokyo, JP) |
Nucleic acids encoding calcitonin receptor and uses thereof
The Drawings The drawings are first described. FIGS. 1A and 1B are a composite of graphs depicting binding of porcine calcitonin to cells. FIG. 1A) Porcine calcitonin binding to LLC-PK.sub.1 cells; F... Read More
Inventors: Goldring, Steven R.; Gorn, Alan H.; Lin, Herb Y.;, Assignee: The General Hospital Corporation (Boston, MA) |
Tricyclic macrolide antibacterial compounds
OF THE INVENTION Compounds of this invention, also referred to as "the compounds," comprise both fixed and variable moieties, which variable moieties are identified by a capital letter and accompanyi... Read More
Inventors: Gu, Yu-Gui; Ma, Zhenkun; Yong, Hong;, Assignee: |
Gene encoding MNR2 and uses thereof
OF THE INVENTION The following standard abbreviations are used throughout the specification to indicate specific nucleotides: C=cytosine A=adenosine T=thymidine G=guanosine This invention provides an... Read More
Inventors: Jessell, Thomas M.; Tanabe, Yasuto; William, Christopher;, Assignee: The Trustees of Columbia University in the City of New York (New York, NY) |
Polyene microlide pre-liposomal powders
OF THE PREFERRED EMBODIMENT A stable powder suitable for the direct preparation of liposome-incorporated antifungal polyene macrolides may be made by a process of the present invention. While the con... Read More
Inventors: Mehta, Reeta; Lopez-Berestein, Gabriel;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Process for stabilizing liposomes
We claim: 1. A process for stabilizing liposomes comprising: a) first forming liposomes by hydrating a lipid film with an aqueous solution containing less than 10 mM of ionic species; and b) then dial... Read More
Inventors: Law, Say-Jong; Piran, Uri;, Assignee: Ciba Corning Diagnostics Corp. (Medfield, MA) |
cDNA encoding human phospholipase A.sub.2 polypeptide
OF THE INVENTION The present invention provides a novel intracellular human phospholipase A.sub.2 that employs a catalytic strategy distinct from that utilized by extracellular phospholipases A.sub.2... Read More
Inventors: Gross, Richard;, Assignee: Washington University (St. Louis, MO) |
DNA encoding Bcl-2-associated proteins
The present invention relates to a nucleic acid molecule encoding a protein or a fragment thereof that associates with Bcl-2 or a Bcl-2-related protein. The invention also relates to Bcl-2-associated ... Read More
Inventors: Reed, John C.; Takayama, Shinichi; Sato, Takaaki;, Assignee: La Jolla Cancer Research Foundation (La Jolla, CA) |
Hybridoma-producing NSO myeloma cell line
This invention is directed to NSO.sup.bcl-2 myeloma cells and to methods of producing said cells. The NSO.sup.bcl-2 myeloma cells of the invention have high fusion frequency, and are fused with B cell... Read More
Inventors: Diamond, Betty A.; Ray, Subhransu;, Assignee: Albert Einstein College of Medicine of Yeshiva University, a Division of (Bronx, NY) |
Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
OF THE PREFERRED EMBODIMENTS The present invention provides an improved method for the encapsulation of high molecular weight nucleic acids in liposomes, wherein a higher nucleic acid entrapment effi... Read More
Inventors: Thierry, Alain; Dritschilo, Anatoly;, Assignee: Georgetown University (Washington, DC) |
Bax inhibitor proteins
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor proteins, including Bax inhibitor protein-1 (BI-1) and Bax inhibitor protein-2 (BI-2), nucleic acid ... Read More
Inventors: Reed, John C.; Xu, Qunli;, Assignee: The Burnham Institute (La Jolla, CA) |
Phosphonomonoester nucleic acids, process for their preparation, and their use
What is claimed is: 1. A compound of formula I ##STR37## in which n is a number from zero to 100; A independently of one another is a single bond, a methylene group or a group of formula IIa or IIb; #... Read More
Inventors: Peyman, Anuschirwan; Uhlmann, Eugen; Breipohl, Gerhard; Wallmeier, Holger;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Oligonucleotide phosphate esters
OF THE PREFERRED EMBODIMENTS The present invention provides oligonucleotide analogs characterized by having at least one internucleotide phosphate bond modified as alkyl phosphotriester. The remainin... Read More
Inventors: Dale, Roderic M. K.; Arrow, Amy; Srivastava, Suresh C.; Raza, Syed K.;, Assignee: ChemGenes Corporation (Ashland, MA); Oligos Etc., Inc. (Wilsonville, OR) |
Liposomes containing oligonucleotides
What we claim is: 1. A composition comprising cationic liposomes which consist essentially of dimethyldioctadecyl ammonium bromide (DDAB), phosphatidylcholine (PC), and cholesterol, and having encapsu... Read More
Inventors: Kasid, Usha; Gokhale, Prafulla; Dritschilo, Anatoly; Rahman, Aquilur;, Assignee: Georgetown University School of Medicine (Washington, DC) |
Protonated/acidified nucleic acids and methods of use
OF THE PREFERRED EMBODIMENTS It is to be understood that this invention is not limited to the particular methodology, protocols, cell lines, animal species or genera, constructs, and reagents describ... Read More
Inventors: Dale, Roderic M. K.; Arrow, Amy; Gatton, Steven L.; Thompson, Terry;, Assignee: Oligos Etc., Inc. (Wilsonville, OR) |
Oligonucleotide derivatives
What is claimed is: 1. A compound which is selected from the group consisting of the base oligonucleotide sequences 5'-AATCCTCCCCCAGTTCACCC-3', SEQ ID NO: 3; and 5'-GGCAGGCATGTTGACTTCAC-3', SEQ ID NO:... Read More
Inventors: Ziegler, Annemarie; Zangemeister-Wittke, Uwe; Fabbro, Doriano; Altmann, Karl-Heinz;, Assignee: Novartis AG (Basel, CH) |
Crystal forms of azithromycin
The present invention relates to crystal forms of azithromycin. As used herein, the term "crystal form(s)" or "form(s)", unless otherwise noted, means one or more crystal forms of azithromycin. In par... Read More
Inventors: Li, Zheng J.; Trask, Andrew V.;, Assignee: Pfizer Inc. (New York, NY) |
Method for delivering melanin to hair follicles
It has now been discovered that liposomes can selectively target the hair follicle with potentially beneficial compounds. Basically, this method comprises preparing liposomes, incorporating beneficial... Read More
Inventors: Li, Lingna; Lishko, Valeryi K.;, Assignee: AntiCancer, Inc. (San Diego, CA) |
Gene Therapy 
