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| Latest patents |
Results: 361-390 of 4797
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Human G-protein coupled receptor
What is claimed is: 1. An isolated polynucleotide comprising a nucleotide sequence chosen from: a) a nucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 or SEQ ID NO: 7; b) a nucleotide se... Read More
Inventors: Deleersnijder, Willy; Nys, Guy; Venema, Jakob; Berger, Claudia; ken, Christiane;, Assignee: Solvay Pharmaceuticals B.V. (CP Weesp, NL) |
Use of a polysaccharide excreted by the Vibrio diabolicus species in bone repair
The invention claimed is: 1. A bone reconstruction biomaterial, comprising a polysaccharide excreted by the Vibrio diabolicus species having cicatrizing activity, and at least one of an osteoconductiv... Read More
Inventors: Guezennec, Jean; Zanchetta, Philippe;, Assignee: Institut Francais de le Recherche pour l'Exploitation de la Mer (Issey les Moulineaux, FR) |
Composition for treatment of and method of monitoring hepatitis C virus using interferon-TAU
OF THE INVENTION I. Definitions Hepatitis C virus or HCV refers to the viral species of which pathogenic types cause Non-A Non-B Hepatitis (NANBH), and attenuated types or defective interfering parti... Read More
Inventors: Sokawa, Yoshihiro; Liu, Chih-Ping;, Assignee: Pepgen Corporation (Alameda, CA) |
Anti-viral guanosine-rich oligonucleotides
In one embodiment of the present invention, there is provided a method of treating a pathophysiological state caused by a virus, comprising the step of administering a pharmacological dose of an oligo... Read More
Inventors: Rando, Robert F.; Fennewald, Susan; Zendegui, Joseph G.; Ojwang, Joshua O.;, Assignee: Aronex Pharmaceuticals, Inc. (The Woodlands, TX) |
Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage
OF THE PREFERRED EMBODIMENTS The present invention is predicated in part on a base specific cleavage reaction to generate a set of small oligonucleotides bounded by the base cleaved. The nucleic acid... Read More
Inventors: Foote, Simon; Elso, Colleen; Simpson, Richard; Reid, Gavin;, Assignee: The Walter and Eliza Hall Institute of Medical Research (Victoria, AU) |
Polymer microparticles for drug delivery
OF THE INVENTION The term microparticle is used herein to include nanoparticles. The microparticles preferably have a size in the range 10 nm to 200.mu.m. The water-soluble polymer is preferably solu... Read More
Inventors: Yeh, Ming-Kung; Coombes, Alan Gerald; Jenkins, Paul George; Davis, Stanley Stewart;, Assignee: Danbiosyst UK Limited (Nottingham, GB) |
Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof
The present invention provides bioactive agents encapsulated in a rapidly releasing polymeric composition capable of inducing or potentiating an immune response and methods for their use. In accordanc... Read More
Inventors: Staas, Jay K.; Tice, Thomas R.; Raychaudhuri, Syamal; Sleath, Paul R.;, Assignee: Southern Research Institute (Birmingham, AL); Corixa Corporation (Seattle, WA) |
Disaccharide derivatives for treating hyperglycaemia
The invention claimed is: 1. A drug composition comprising an active ingredient and a carrier in which said active ingredient is an amide or alkyl ester of an oxidized disaccharide and wherein the oxi... Read More
Inventors: Heinz, Fritz; Hertel, Sabine; Kunz, Markwart; Vogel, Manfred;, Assignee: Sudzucker Aktiengesellschaft Mannheim Ochsenfurt (DE) |
Gene expression profiles in liver cancer
1. A method of diagnosing hepatocellular carcinoma in a human patient, compnsing: (a) detecting the level of expression in a tissue sample of ten or more genes from Tables 3A, 3B, 5, 7A, 7B, 8A, and 8... Read More
Inventors: Horne, Darci T.; Scherf, Uwe; Vockley, Joseph;, Assignee: Gene Logic, Inc. (Gaithersburg, MD) |
Endovascular cardiac venting catheter and method
The present invention is directed to an endovascular approach for preparing a patient's heart for cardiac procedures which does not require a grossly invasive thoracotomy. The invention facilitates ve... Read More
Inventors: Stevens, John H.; Krier, Jeffrey W.; Valley, Kirsten L.; Evard, Philip C.;, Assignee: Heartport, Inc. (Redwood City, CA) |
Bone morphogenic protein-5(BMP-5) and DNA encoding same
OF THE INVENTION Purified human BMP-5 proteins are produced by culturung a host cell transformed with the DNA sequence of Table III. The expressed BMP-5 proteins are isolated and purified from the cu... Read More
Inventors: Wozney, John M.; Rosen, Vicki A.; Wang, Elizabeth A.;, Assignee: Genetics Institute, Inc. (Cambridge, MA) |
Adipocyte-specific protein homologs
Within one aspect of the invention is provided an isolated polypeptide comprising a sequence of amino acid residues that is at least 80% identical to SEQ ID NO:2, wherein the sequence comprises: beta ... Read More
Inventors: Sheppard, Paul O.; Humes, Jacqueline M.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
LSR receptor, activity, cloning, and uses for diagnosing, preventing and/or treating obesity and related risks or complications
The LSR receptor The invention relates to a purified LSR receptor (<<Lipolysis Stimulated Receptor>>), preferably hepatic, consisting of at least one .alpha. or .alpha.' subunit and at le... Read More
Inventors: Bihain, Bernard; Bougueleret, Lydie; Yen-Potin, Frances;, Assignee: Genset, S.A. (FR); Institute National de la Sante et de la Recherche Medicale (INSERM) (FR) |
Multi-functional chimeric hematopoietic receptor agonists
1. A hematopoietic protein comprising; an amino acid sequence of the formula: Met-1 R1-L1-R2, Met-2 Ala-1 P1-L1-R2, Ala-1 R1-L1-R2, R1-L1-R2, Met-1 R2-L1-R1, Met-2 Ala-1 R2-L1-R1, Ala-1 R2-L1-R1, R2-L... Read More
Inventors: Mc Kearn, John P.; McWherter, Charles A.; Feng, Yiqing; Summers, Neena L.; Staten, Nicholas R.; Streeter, Philip R.; Woulfe, Susan L.; Minster, Nancy I.; Minnerly, John C.;, Assignee: |
Composition and method for treatment and prevention of traumatic synovitis and damage to articular cartilage
OF THE INVENTION Additional objects, advantages and other novel features of the invention will be set forth in part in the description that follows and in part will become apparent to those skilled i... Read More
Inventors: Marcum, Frank D.;, Assignee: |
DNA sequences comprising dystrophin minigenes and methods of use thereof
The present invention provides dystrophin minigenes that are significantly reduced in size without compromising essential functions in protecting muscles from dystrophic phenotypes. The present invent... Read More
Inventors: Xiao, Xiao;, Assignee: Asklêpios Biopharmaceutical, Inc. (Chapel Hill, NC) |
Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same
1. A composition for use in preparing an intron containing vector, said composition comprising: a donor vector comprising at least one splice site and an acceptor vector comprising at least one splice... Read More
Inventors: Farmer, Andrew Alan;, Assignee: Clontech Laboratories, Inc. (Mountain View, CA) |
Pharmaceutical composition and method for hypermetabolic weight loss
The present invention relates to a device, pharmaceutical composition and method for metabolizing fatty acids into water, carbon dioxide and heat and thereby reducing an individual's white adipose tis... Read More
Inventors: Bills, Nathan;, Assignee: Hypermetabolic Therapies, Inc. (Corvallis, OR) |
Method for manufacturing glycoproteins having human-type glycosylation
What is claimed is: 1. A method of manufacturing a glycoprotein having a sugar chain, comprising a step in which a transformed plant cell is produced by introducing to a plant cell a gene encoding a m... Read More
Inventors: Seki, Tatsuji; Fujiyama, Kazuhito;, Assignee: The Dow Chemical Company (Midland, MI) |
Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
What is claimed is: 1. A compound of the formula: ##STR2## wherein: a is from 0 to 6,: b is from 0 to 4; R, R' and R" are hydrogen, hydrocarbyl, heterosubstituted hydrocarbyl or heterosubstituent of n... Read More
Inventors: Glazer, Alexander N.; Benson, Scott C.;, Assignee: The Regents of the University of California (Berkeley, CA) |
Nucleic acid analogue induced transcription of double stranded DNA
We claim: 1. A method of transcribing RNA, using a double-stranded DNA as a template, comprising: (a) hybridizing said double-stranded DNA with a least one oligo-nucleic acid analogue to form a hybrid... Read More
Inventors: Berg, Rolf Henrik; Buchardt, deceased, Ole; Egholm, Michael; Nielsen, Peter Eigil;, Assignee: Boehringer Mannheim GmbH (Mannheim, DE) |
Peptide nucleic acid combinatorial libraries
OF THE INVENTION The synthesis of peptide nucleic acids (also known as PNA) via preformed monomers were first described in PCT patent applications WO 92/20702, WO 92/20703, the contents of which are ... Read More
Inventors: Cook, Phillip Dan; Kiely, John; Sprankle, Kelly;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Nucleic acid-containing polymerizable complex
OF THE INVENTION The present invention is based on the development of a polymerizable complex comprised of a first polymerizable ethylene-containing monomer unit covalently linked to a nucleic acid m... Read More
Inventors: Boles, T. Christian; Kron, Stephen J.; Adams, Christopher P.;, Assignee: Mosaic Technologies, Inc. (Boston, MA) |
Chiral peptide nucleic acids and methods for preparing same
OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the development of biological probes and new reagents for use in research (Uhlmann, E., Peyman, A., Chem. ... Read More
Inventors: Teng, Kelly;, Assignee: ISIS Pharmaceuticals, Inc. (Carlsbad, CA) |
Capillary electrophoretic detection of nucleic acids
OF THE PREFERRED EMBODIMENTS This invention provides novel methods for the detection and isolation of nucleic acids, nucleic acid fragments or other nucleic acid like species that have specific nucle... Read More
Inventors: Cummins, Lendell L.; Freier, Susan M.; Griffey, Richard; Srivatsa, G. Susan;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
PNA diagnostic methods
The present invention provides methods for detecting nucleic acid sequences and/or determining sequence information from nucleic acids. Probes according to the present invention include PNA. The inven... Read More
Inventors: Nie, Eileen Xiao-Feng; Wu, Yuan Min;, Assignee: Lorne Park Research, Inc. (Toronto, CA) |
Histidine-containing peptide nucleic acids
OF THE INVENTION Specific sequence recognition of DNA or RNA is of increasing importance for the development of biological probes and new reagents for use in research (Uhlmann, E., Peyman, A., Chem. ... Read More
Inventors: Nielsen, Peter E.; Buchardt, deceased, Ole; Berg, Rolf H.; Egholm, Michael;, Assignee: |
Two-step hybridization and capture of a polynucleotide
According to one aspect of the invention, there is disclosed a method of capturing a target polynucleotide present in a sample. The method includes the steps of incubating a mixture comprising a targe... Read More
Inventors: Weisburg, William G.; Shaw, Jay H.; Becker, Michael M.; Majlessi, Mehrdad;, Assignee: Gen-Probe Incorporated (San Diego, CA) |
Peptide nucleic acid conjugates
OF THE INVENTION According to the present invention a PNA oligomer is conjugated to a ligand having a cognate receptor on the surface of a cell. The ligand facilitates the penetration and transport o... Read More
Inventors: Wickstrom, Eric; Basu, Soumitra;, Assignee: Thomas Jefferson University (Philadelphia, PA) |
High throughput assay system
This invention provides compositions, apparatus and methods for concurrently performing multiple biological or chemical assays, and allows for high throughput analysis of multiple samples--for example... Read More
Inventors: Felder, Stephen; Kris, Richard M.;, Assignee: NeoGen, Inc. (Tucson, AZ) |
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Gene Therapy 
