Synthetic polymers and methods, kits or compositions for modulating the solubility of same
As previously discussed, the limited solubility of PNA oligomers, and particularly purine-rich oligomers, is well documented in the chemical literature. Though not exclusively a problem associated wit... Read More
Inventors: Gildea, Brian D.; Coull, James M.;, Assignee: Boston Probes, Inc. (Bedford, MA) |
Neurologically-active compounds
The inventors have found a class of compounds which are surprisingly selective GABAC receptor antagonists. The compounds of the invention also have a lipid solubility which results in an increased abi... Read More
Inventors: Chebib, Mary; Hanrahan, Jane; Johnston, Graham A. R.;, Assignee: The University of Sydney (Sydney, AU); Polychip Pharmaceuticals Pty. Ltd. (Toorak, AU) |
Once a day antihistamine and decongestant formulation
The present invention is a controlled release pharmaceutical formulation comprising effective amounts of both an antihistamine and a decongestant that is easy to manufacture. A preferred embodiment of... Read More
Inventors: Sriwongjanya, Mongkol; Weng, Timothy; Barman, David; Kositprapa, Unchalee;, Assignee: Andrx Pharmaceuticals, Inc. (Davie, FL) |
Thermostable isomerase and use hereof, in particular for producing tagatose
What is claimed is: 1. An L-arabinose isomerase capable of isomerizing D-galactose to D-tagatose, which isomerase has at least 90% sequence identity to the sequence of SEQ ID NO:2. 2. The isomerase o... Read More
Inventors: Hansen, Ole C.; Jorgensen, Flemming; Stougaard, Peter; Bertelsen, Hans; Bottcher, Karen; Christensen, Hans Jo; Eriknauer, Kristian;, Assignee: Bioneer A/S (DK) |
Linear liquid dispensing pump for dispensing liquid in nanoliter volumes
What is claimed is: 1. In a rotary/reciprocating liquid dispensing pump including: a relatively stationary pump housing having means defining a smooth elongated cylindrical bore sealable closed at one... Read More
Inventors: Tanny, Mark N.; LeBlanc, Raymond A.; Bensley, Douglas S.; Zeitz, Vernon W.; Barney, John E.;, Assignee: Ivek Corporation (North Springfield, VT) |
Apparatus and method for polymer synthesis using arrays
What is claimed is: 1. A polymer synthesis apparatus for building a polymer chain by sequentially adding polymer units to a solid support in a liquid reagent comprising: a base assembly including a re... Read More
Inventors: Brennan, Thomas M.;, Assignee: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA) |
Biopolymer synthesis using surface activated biaxially oriented polypropylene
OF PREFERRED EMBODIMENTS The solid phase synthesis of biopolymers (e.g., oligonucleotides, peptides, oligosaccharides, lipids, etc.) requires, by definition, a solid support material from which the i... Read More
Inventors: Coassin, Peter J.; Matson, Robert S.; Rampal, Jang B.;, Assignee: Beckman Instruments, Inc. (Fullerton, CA) |
Energy transfer dyes with enhanced fluorescence
I. Energy Transfer Dye Linkers Of The Present Invention The present invention relates to novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye. The present in... Read More
Inventors: Lee, Linda G.; Spurgeon, Sandra L.; Rosenblum, Barnett;, Assignee: Perkin-Elmer Corporation (Foster City, CA) |
Methods for electronic stringency control for molecular biological analysis and diagnostics
The present invention relates to the design, fabrication, and uses of programmable, self-addressable and self-assembling microelectronic systems and devices which can actively carry out controlled mul... Read More
Inventors: Heller, Michael J.;, Assignee: Nanogen, Inc. (San Diego, CA) |
Methods for fabricating microarrays of biological samples
The invention includes, in one aspect, a method of forming a microarray of analyte-assay regions on a solid support, where each region in the array has a known amount of a selected, analyte-specific r... Read More
Inventors: Shalon, Tidhar Dari; Brown, Patrick O.;, Assignee: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA) |
Promoter sequences providing male tissue-preferred expression in plants
This invention relates to nucleic acid sequences, and, specifically, DNA molecules and the amino acid encoded by the DNA molecules, which are critical to male fertility. A promoter of the DNA is ident... Read More
Inventors: Albertsen, Marc C.; Fox, Tim; Huffman, Gary; Trimnell, Mary;, Assignee: Pioneer Hi-Bred International, Inc. (Johnston, IA) |
Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
1. A composition comprising at least one salt chosen from alkali and alkaline-earth metal salts of at least one sulphated polysaccharide of heparin, said salts of at least one sulphated polysaccharide... Read More
Inventors: Pecquet, Christelle; Perrin, Elisabeth; Viskov, Christian;, Assignee: Aventis Pharma S.A. (Antony Cedex, FR) |
Transcriptional activators with graded transactivation potential
OF THE INVENTION In the following subsections, transactivator fusion proteins of the invention having graded transcriptional activation potentials are primarily described in the context of tetracycli... Read More
Inventors: Baron, Udo; Gossen, Manfred; Bujard, Hermann;, Assignee: BASF Aktiengesellschaft (Ludwigshafen, DE); Baron; Udo (St. Ilgen, DE) |
Inducible expression system
The present invention features compositions and methods for the inducible expression of a polypeptide, especially a polypeptide normally cytotoxic to the eukaryotic host cell in which it is to be expr... Read More
Inventors: Yee, Jiing-Kuan; Friedmann, Theodore; Chen, Shin-Tai;, Assignee: City of Hope (Duarte, CA); The Regents of the University of California (Oakland, CA) |
Article of manufacture comprising semipermeable polymer and dextran derivative
This invention concerns a device for delivering a beneficial agent to an environment of use. The device comprises a pressure generating member surrounding a variable volume chamber filled with agent a... Read More
Inventors: Theeuwes, Felix;, Assignee: ALZA Corporation (Palo Alto, CA) |
Dispenser for delivering fluids and solids
This invention concerns a dispenser for delivering an agent to an environment of use. The dispenser comprises an intermediate layer of an osmotically effective solute that at least partly covers an in... Read More
Inventors: Michaels, Alan S.;, Assignee: ALZA Corporation (Palo Alto, CA) |
Portable device for infusing insulin on the basis of glycemic measurements
The device is made by a concentric dual lumen catheter, a pump, a hemofilter, a glucose sensor which, by means of a microinfusion pump with a stepping motor can, through another dual lumen concentric ... Read More
Inventors: Bernardi, Luigi;, Assignee: |
Device for administering a liquid in a number of doses
I claim: 1. A device for administering a liquid in a number of doses, such as insulin to a patient, said device comprising a piston being reciprocatably disposed in a pump chamber, a cannula being con... Read More
Inventors: Smit, Cornelis;, Assignee: |
Release rate adjustment of osmotic or diffusional delivery devices
In accomplishing the foregoing and related objects, the invention provides a device which covers a portion of the transport area of osmotic or diffusional delivery devices. Osmotic or diffusional flui... Read More
Inventors: Eckenhoff, James B.; Urquhart, John;, Assignee: ALZA Corporation (Palo Alto, CA) |
Portable infusion device assembly
The present invention provides a portable controlled release infusion pump assembly. The assembly includes a housing with two side-by-side compartments. The dimensions of the housing will vary accordi... Read More
Inventors: Faste, Rolf A.;, Assignee: Pharmetrix Corporation (Menlo Park, CA) |
Delivery system comprising means for delivering agent to livestock
OF THE DRAWING FIGURES Turning now to the drawing figures in detail, which drawing figures are examples of various delivery systems provided by the invention, and which examples are not to be constru... Read More
Inventors: Magruder, Judy A.; Eckenhoff, James B.; Cortese, Richard; Wright, Jeremy C.; Peery, John R.;, Assignee: Alza Corporation (Palo Alto, CA) |
Controlled release infusion device
Objects of the invention It is an object of the invention to provide an improved portable controlled release infusion device that can be operated in such a manner so as to minimize the delay between a... Read More
Inventors: Kam, Robert J.; Faste, Rolf A.; Castro, Anthony J.;, Assignee: |
Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
The present invention resides in an osmotic delivery capsule which produces an intermittent or pulsatile release of the beneficial agent by virtue of the structure of the capsule itself rather than th... Read More
Inventors: Linkwitz, Andreas; Magruder, Judy A.; Merrill, Sonya;, Assignee: Alza Corporation (Palo Alto, CA) |
Controlled release osmotic infusion system
Obiects of the invention It is an object of the invention to provide a portable controlled release infusion device that can be stored, with or without the infusate, for prolonged periods without deter... Read More
Inventors: Athayde, Amulya L.; Faste, Rolf A.;, Assignee: PharMetrix Corporation (Menlo Park, CA) |
Syringe-filling medication dispenser
The present invention is directed to a medication dispenser which can be used with one or more conventional medication vials to supply a conventional syringe with a desired amount of the one or more l... Read More
Inventors: Haber, Terry M.; Smedley, William H.; Foster, Clark B.;, Assignee: Habley Medical Technology Corporation (Laguna Hills, CA) |
Implantable cardiac electrode with rate controlled drug delivery
The present invention provides a means for controllably releasing one or more drugs from an implantable lead. Both acceleration and deceleration of drug elution may be desired throughout the use of th... Read More
Inventors: Hoffmann, Drew A.; Bush, M. Elizabeth;, Assignee: Ventritex, Inc. (Sunnyvale, CA) |
Method for enhancing the anti-tumor therapeutic index of interleukin-2
The present invention is a method for enhancing the therapeutic index of IL-2 treatment. The method is a manner of delivering IL-2 to a patient such that the IL-2 concentration in the patients' plasma... Read More
Inventors: Bauer, Robert J.; Winkelhake, Jeffrey L.; Young, John D.; Zimmerman, Robert;, Assignee: Chiron Corporation (Emeryville, CA) |
Ribozyme amplified diagnostics
A system is described for the use of a ribozyme as a diagnostic tool for detecting the presence of a nucleic acid, protein, or other molecules, in which the formation of an active ribozyme and cleavag... Read More
Inventors: Shih, Andy; Bockman, Jeffrey M.; George, Shaji T.;, Assignee: Innovir Laboratories, Inc. (New York, NY) |
Hairpin ribozymes
We claim: 1. A Hairpin ribozyme lacking a substrate moiety, comprising between six and eight bases inclusive in helix 2 and able to base-pair with a separate substrate RNA, wherein said ribozyme compr... Read More
Inventors: Chowrira, Bharat; McSwiggen, James;, Assignee: Ribozyme Pharmaceuticals, Inc. (Boulder, CO) |
Modified ribozymes
We claim: 1. An RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the ribose sugar is replaced by a modifier group, wher... Read More
Inventors: Eckstein, Fritz; Pieken, Wolfgang; Benseler, Fritz; Olsen, David B.; Williams, David M.; Heidenreich, Olaf;, Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V. (Gottingen, DE) |
Gene Therapy 
