Regulatable RNA molecule
Construction of a regulatable ribozyme is described in which a ribozyme sequence is linked to a ligand-binding sequence, placing the activity of the ribozyme under the control of that ligand and requi... Read More
Inventors: George, Shaji T.; Shih, Andy; Bockman, Jeffrey Michael;, Assignee: Innovir Laboratories, Inc. (New York, NY) |
Method for detecting a nucleic acid involving the production of a triggering RNA and transcription amplification
The present invention is based on a novel concept for the detection of a nucleic acid sequence present in a sample (assayed nucleic acid). The present invention is useful for the detection of a nuclei... Read More
Inventors: Nathan, Asher;, Assignee: Intelligene Ltd. (IL) |
Apparatus for diverse chemical synthesis using two-dimensional array
OF THE INVENTION While the present invention will be described with reference to certain specific embodiments, the description is illustrative of the invention and is not to be construed as limiting ... Read More
Inventors: Brennan, Thomas M.;, Assignee: Protogene Laboratories, Inc. (Palo Alto, CA) |
Oligoribonucleotides and ribonucleases for cleaving RNA
In accordance with this invention there are provided oligomeric compounds formed from a linear sequence of linked ribonucleoside subunits that are specifically hybridizable to a preselected RNA target... Read More
Inventors: Crooke, Stanley T.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Pharmaceutical compositions and methods for treating acne
OF THE PREFERRED EMBODIMENTS A pharmaceutical composition for treating acne and conditioning the skin cells has now been discovered. The pharmaceutical composition includes an acne reducing component... Read More
Inventors: Murad, Howard;, Assignee: |
Amido macrolides
1. A compound or pharmaceutically acceptable salt thereof having the formula ##STR121## wherein R1 is C1-C8 substituted or unsubstituted alkyl, C2-C8 substituted or unsubstituted alkenyl, C2-C8 substi... Read More
Inventors: Ashley, Gary; Shaw, Simon James; Li, Yandong; Myles, David C.;, Assignee: Kosan Biosciences, Inc. (Hayward, CA) |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
OF THE INVENTION The synthetic route used to prepare active sulfones of poly(ethylene glycol) and related polymers comprises at least four steps in which sulfur is bound to a polymer molecule and the... Read More
Inventors: Harris, J. Milton;, Assignee: Shearwater Polymers, Inc. (Huntsville, AL) |
Coating compositions having improved scratch resistance, coated substrates and methods related thereto
OF THE DRAWINGS FIG. 1 is a transmission electron micrograph (30,000.times. magnification) of a cross-section of a cured transparent topcoating composition of the present invention which contains bot... Read More
Inventors: Anderson, Lawrence G.; Barkac, Karen A.; DeSaw, Shawn A.; Hartman, Marvis E.; Hayes, Deborah E.; Hockswender, Thomas R.; Kuster, Kymarie L.; Nakajima, Masayuki; Olson, Kurt G.; Sadvary, Richard J.; Simpson, Dennis A.; Tyebjee, Shiryn; Wilt, Truman F.;, Assignee: PPG Industries Ohio, Inc. (Cleveland, OH) |
Fusion polypeptide comprising two ligand binding domains
In one embodiment, the present invention provides a non-naturally occurring polypeptide that contains two ligand binding domains operatively linked to each other and a first functional domain operativ... Read More
Inventors: Barbas, III, Carlos F.; Beerli, Roger; Schopfer, Ulrich;, Assignee: The Scripps Research Institute (La Jolla, CA) |
N.sup.6 mono heterocyclic substituted adenosine derivatives
What we claim is: 1. A composition of matter having the formula: ##STR6## wherein R.sub.1 is an unsubstituted or substituted monocyclic heterocyclic group containing from 3 to 15 atoms, at least one o... Read More
Inventors: Lum, Robert T.; Pfister, Jurg R.; Schow, Steven R.; Wick, Michael M.; Nelson, Marek G.; Schreiner, George F.;, Assignee: CV Therapeutics (Palo Alto, CA) |
Method for separating and analyzing ions by electrostatic ion chromatography and a zwitterionic stationary phase for ion chromatography and method for separating and analyzing analytes by multifunctional liquid chromatography
OF THE INVENTION In accordance with the present invention, a support carrier of any material, form or size may be used in the aforementioned "zwitterionic stationary phase", without any specific limi... Read More
Inventors: Wenzhi, Hu;, Assignee: Inoue; Soichi (JP) |
Fuel-injection pump
We claim: 1. A fuel injection pump of the distributor type for supplying a plurality of injection nozzles (29) of internal-combustion engines, which comprises, a rotating drive shaft (13) mounted in a... Read More
Inventors: Helmbrecht, Peter; Fehlmann, Wolfgang; Schultheiss, Gerold; Junger, Dieter; Kebrich, Bodo; Morel-Fourrier, J. Paul;, Assignee: Robert Bosch GmbH (Stuttgart, DE) |
Intermodal bulk container
OF THE PRESENTLY PREFERRED EMBODIMENTS The preferred embodiment described below provides the advantages of a relatively light-weight aluminum vessel mounted within a rigid, high strength steel frame ... Read More
Inventors: Kee, Douglas P.; Russell, Douglas M.; Hicton, Raymond L.;, Assignee: Advance Engineered Products Ltd. (CA) |
Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
OF THE INVENTION The present invention is directed to a novel method for increasing the permeability of skeletal muscle tissue, thus allowing pharmaceutical drugs and nucleic acids to enter or transf... Read More
Inventors: Mathiesen, Iacob; Lomo, Terje;, Assignee: Electrofect AS (Oslo, NO) |
Defective recombinant adenovirus lacking E1A coding sequence and comprising a heterologous nucleotide sequence under control of the E1A promoter
We claim: 1. A defective recombinant Ad2 adenovirus, comprising: a) the E1A promoter of its genome; b) no coding part of the E1A region of its genome; and c) a first heterologous nucleotide sequence e... Read More
Inventors: Perricaudet, Michel; Ballay, Annick; Levredo, Massimo; Tiollais, Pierre;, Assignee: Institut Pasteur (Paris, FR); Centre National de la Recherche Scientifique (Paris, FR); Institut National de la Sante et de la Recherche Medicale (Paris, FR) |
Prevention of atherosclerosis and restenosis
1. A method of inhibiting atherosclerosis in a subject, comprising: a) identifying a subject suspected of needing inhibition of atherosclerosis; and b) administering to said subject PTU in an amount s... Read More
Inventors: Chen, Wei-Jan;, Assignee: |
Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
The invention claimed is: 1. A filamentous polyphage particle which (a) contains (i) a first recombinant vector molecule that comprises a nucleic acid sequence, which encodes a fusion protein of a fir... Read More
Inventors: Rudert, Fritz; Ge, Liming; Ilag, Vic;, Assignee: Morphosys AG (DE) |
HCV replicase complexes
OF THE INVENTION All references cited herein are hereby incorporated by reference in their entireties. This invention is based, in part, on the discovery of specific features of RNA templates and pri... Read More
Inventors: Zhong, Weidong; Hong, Zhi; Ferrari, Eric;, Assignee: Schering Corporation (Kenilworth, NJ) |
11-deoxy azalide antibacterials
OF THE INVENTION Compounds of this invention, also referred to as "the compounds," comprise both fixed and variable "moieties," which variable moieties are identified by a capital letter and accompan... Read More
Inventors: Clark, Richard; Djuric, Stevan; Ma, Zhenkun;, Assignee: Abbott Laboratories (Abbott Park, IL) |
Mammalian multipotent neural stem cells
In accordance with the forgoing objects, the invention includes the isolation, clonal expansion and differentiation of mammalian multipotent neural stem cells such as those derived from the neural cre... Read More
Inventors: Anderson, David J.; Stemple, Derek L.;, Assignee: California Institute of Technology (Pasadena, CA) |
Adenoviral vector incorporating zipper peptide-modified fiber protein and uses thereof
The present invention is directed to a targeted recombinant adenovirus vector comprising (i) a gene encoding a heterologous protein; (ii) a modified fiber protein with a first zipper peptide inserted ... Read More
Inventors: Korokhov, Nikolay; Mikheeva, Galina;, Assignee: Vectorlogics, Inc. (Birmingham, AL) |
Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
OF THE INVENTION The subject invention relates to the use of acylated derivatives of non-methylated pyrimidine nucleosides, i.e. acylated derivatives of uridine, deoxyuridine, cytidine, or deoxycytid... Read More
Inventors: von Borstel, Reid W.; Bamat, Michael K.;, Assignee: Pro-Neuron, Inc. (Rockville, MD) |
Acylated uridine and cytidine and uses thereof
What is claimed is: 1. An acyl derivative of uridine having the formula (II) ##STR4## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl radical of (a) an ... Read More
Inventors: von Borstel, Reid Warren; Bamat, Michael Kevin;, Assignee: Pro-Neuron, Inc. (Gaithersburg, MD) |
Solid formulation of glucosamine sulphate
1. A solid formulation of glucosamine sulphate or a mixed salt thereof, in an effervescent preparation. 2. A formulation according to claim 1, wherein the formulation comprises 500-2000 mg glucosamine... Read More
Inventors: Hans-Jü, rgen; Parekh, Harish;, Assignee: SCA Lohnherstellungs AG (Kirchberg, CH) |
DNA encoding human alpha 1 adrenergic receptors and uses thereof
OF THE INVENTION This invention provides an isolated nucleic acid molecule encoding a human .alpha..sub.1 adrenergic receptor. This invention also provides an isolated nucleic acid molecule encoding ... Read More
Inventors: Bard, Jonathan A.; Weinshank, Richard L.; Forray, Carlos C.;, Assignee: Synaptic Pharmaceutical Corporation (Paramus, NJ) |
Peptides of IL-2 and derivatives thereof
1. An isolated peptide, which consists of the amino acid sequence of SEQ ID NO.: 6 or an amino acid sequence that is at least 95% identical thereto, which binds to IL-2R β-chain and exhibits lym... Read More
Inventors: Theze, Jacques; Eckenberg, Ralph; Moreau, Jean-Louis; Goldberg, Michel; Rose, Thierry; Alzari, Pedro; Mazie, Jean-Claude;, Assignee: Institut Pasteur (Paris Cedex, FR) |
Synthesis of cyclopropane amino acids
What is claimed is: 1. A peptide resistant to enzymatic cleavage selected from the group consisting of: .gradient.Met-Leu-Phe, Met-.gradient.Leu-Phe, pGln-His-.gradient.Pro-NH.sub.2, pGln-.gradient.Hi... Read More
Inventors: Stammer, Charles H.;, Assignee: The University of Georgia Research Foundation, Inc. (Athens, GA) |
Electronic musical instrument
Accordingly, it is the primary object of the present invention is to provide an electronic musical instrument capable of generating musical tones full of sophistication and variety by, when a damper c... Read More
Inventors: Shibukawa, Takeo;, Assignee: Yamaha Corporation (Hamamatsu, JP) |
Methods for producing hybrid phospholipid-binding proteins
I claim: 1. A hybrid phospholipid-binding protein comprising at least one lipocortin phospholipid-binding domain joined to a gla-domainless, vitamin K-dependent protein, wherein said hybrid phospholip... Read More
Inventors: Foster, Donald C.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
Expression and purification of recombinant soluble tissue factor
A method is disclosed to make any protein in a form that can be isolated rapidly from a solution using a specific monoclonal antibody designated "HPC-4". HPC-4 binds a twelve amino acid epitope of Pro... Read More
Inventors: Rezaie, Alireza; Esmon, Charles T.; Morrissey, James H.;, Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK) |
Gene Therapy 
