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Results: 451-480 of 4797
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Cloning and regulation of an endothelial cell protein C/activated protein C receptor
An endothelial cell protein C binding protein (referred to herein as "EPCR") has been cloned and characterized. The protein is predicted to consist of 238 amino acids, which includes a 15 amino acid s... Read More
Inventors: Fukudome, Kenji; Esmon, Charles T.;, Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK) |
Devices and methods for application of intraluminal photopolymerized gels
Having thus described the invention, what we desire to claim and secure by Letters Patent is: 1. A device for delivery of a therapeutic agent to a body cavity or lumen, comprising: one or more elongat... Read More
Inventors: Roth, Laurence A.; Herman, Stephen J.; Khosravi, Farhad; Melanson, David; Dumont, Michael; Campbell, Patrick K.; Spiridigliozzi, John C.;, Assignee: Focal, Inc. (Lexington, MA) |
Modified protein C and methods of use thereof
Modified Protein C molecules can be made which substitute the gamma carboxylglutamic acid (Gla) region of another Vitamin K dependent protein, most preferably prothrombin, for the native region of the... Read More
Inventors: Esmon, Charles T.; Smirnov, Mikhail D.;, Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK) |
Cloning and regulation of an endothelial cell protein C/activated protein C receptor
An endothelial cell protein C binding protein (referred to herein as "EPCR") has been cloned and characterized. The protein is predicted to consist of 238 amino acids, which includes a 15 amino acid s... Read More
Inventors: Fukudome, Kenji; Esmon, Charles T.;, Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK) |
Mixed gas microbubble compositions
OF THE INVENTION As used in the present description and claims, the terms "vapor" and "gas" are used interchangeably. Similarly, when referring to the tension of dissolved gas in a liquid, the more f... Read More
Inventors: Schutt, Ernest G.; Evitts, David P.; Kinner, Rene Alta; Anderson, Charles David; Weers, Jeffry G.;, Assignee: Imcor Pharmaceutical Company (San Diego, CA) |
Water-soluble, sulfoalkyl-containing, hydrophobically modified cellulose ethers, process for preparing them, and their use as protective colloids in polymerizations
1. A water-soluble ionic cellulose ether from the group of hydroxyalkylcelluloses with more than 2.3 hydroxyalkyl groups per anhydroglucose unit, which is substituted by on average from 0.001 to 1.0 C... Read More
Inventors: Doenges, Reinhard; Wurm, Horst;, Assignee: SE Tylose GmbH & Co., KG (Wiesbaden, DE) |
Cell-culture and polymer constructs
What is claimed is: 1. A surgical procedure wherein chondrocytes are taken from a patient and rapidly multiplied and transplanted into said patient for cartilage repair, comprising the steps of: 1) ob... Read More
Inventors: Hungerford, David S.; Frondoza, Carmelita G.; Sohrabi, Afshin; Shikani, Alan H.; Domb, Abraham J.;, Assignee: Chondros, Inc. (Towson, MD) |
Apo-2 ligand
Applicants have identified cDNA clones that encode a novel cytokine, designated "Apo-2 ligand." It is presently believed that Apo-2 ligand is a member of the TNF cytokine family; Apo-2 ligand is relat... Read More
Inventors: Ashkenazi, Avi J.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Electrical cable having at least its leading end partially prepared for jointing prior to laying
I claim: 1. A length of cable of the type comprising a conductor, polymeric insulation over the conductor, a semiconducting screen over the polymeric insulation, a fault carrying screen over the semic... Read More
Inventors: Ball, Edmund H.;, Assignee: Pirelli General plc (London, GB2) |
Gene transcription and ionizing radiation: methods and compositions
OF THE INVENTION I. The Invention The present invention relates to compositions and methods for regulating transcription of an encoding DNA sequence and expression of a polypeptide encoded by that se... Read More
Inventors: Weichselbaum, Ralph R.; Hallahan, Dennis E.; Sukhatme, Vikas P.; Kufe, Donald W.;, Assignee: Arch Development Corporation (Chicago, IL) |
Formulations and methods for providing prolonged local anesthesia
Accordingly, the present invention provides for pharmaceutically acceptable augmenting agent or agents in conjunction with a local anesthetic in controlled release form that significantly increases t... Read More
Inventors: Chasin, Mark; Goldenheim, Paul; Sackler, Richard; Tigner, Joseph; Burch, Ronald M;, Assignee: Euro-Celtique S.A. (Luxembourg, LU) |
Methods for the diagnosis and treatment of insulin-dependent diabetes mellitus
It is an object of the present invention to provide methods for detecting the status of insulin-dependent diabetes mellitus (IDDM)-associated autoimmunity in a mammal who is at risk of developing the ... Read More
Inventors: Kaufman, Daniel L.; Tian, Jide;, Assignee: The Regents of the University of California (Oakland, CA) |
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
OF THE INVENTION A population of cells exists within the adult central nervous system (CNS) which exhibit stem cell properties, in their ability to self-renew and to produce the differentiated mature... Read More
Inventors: Buck, David W.; Uchida, Nobuko; Weissman, Irving;, Assignee: StemCells California, Inc. (Palo Alto, CA) |
Therapeutic composition for broad spectrum dermal disease
Therefore, the present invention has been made in view of the above problems, and is directed to a therapeutic composition for a broad spectrum of skin diseases. In some aspects of the invention, the ... Read More
Inventors: Park, Chang Seo; Kim, Jin Wook; Choi, Jin Hee; Koh, Ui Chan;, Assignee: Doosan Corporation (KR) |
Schwann cells originating in myeloid interstitial cells
OF THE INVENTION According to one mode of the present invention there is provided a method of inducing bone marrow stromal cells to differentiate into bone marrow stromal cell-derived Schwann cells i... Read More
Inventors: Dezawa, Mari; Sawada, Hajime; Takano, Masahiko;, Assignee: Sanbio, Inc. (Mountain View, CA) |
Delivery of a therapeutic agent in a formulation for reduced toxicity
OF THE INVENTION The following terms shall have the meanings indicated herein and in the claims, unless required otherwise by the context. The term "subject" is defined here and in the claims as a ma... Read More
Inventors: Klyosov, Anatole; Platt, David;, Assignee: |
Therapeutic azide compounds
OF THE PREFERRED EMBODIMENTS A preferred class of the azide derivatives of this invention are azide derivatives of biologically active purines and pyrimidines, nucleoside analogs, and phosphorylated ... Read More
Inventors: Chu, Chung K.; Kotra, Lakshmi P.; Manouilov, Konstantine; Du, Jinfa; Schinazi, Raymond;, Assignee: The University of Georgia Research Foundation, Inc. (Athens, GA); Emory University (Atlanta, GA) |
Prostate-specific membrane antigen and uses thereof
OF THE INVENTION Throughout this application, references to specific nucleotides are to nucleotides present on the coding strand of the nucleic acid. The following standard abbreviations are used thr... Read More
Inventors: Israeli, Ron S.; Heston, Warren D. W.; Fair, William R.;, Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY) |
Cloning, overexpression and therapeutic use of bioactive histidine ammonia lyase
Accordingly, it is an object of the invention to provide a purified polypeptide having a histidine ammonia lyase activity that is not substantially inhibited by a histidine analog, such as histidinol.... Read More
Inventors: Roberts, Joseph; Sethuraman, Natarajan; MacAllister, Thomas;, Assignee: University of South Carolina (SC) |
Human insulin receptor endocytic code binding protein
The present invention provides a novel polypeptide which is characterized as binding to the endocytic code of the human insulin receptor (hIR); and having an amino acid sequence according to Sequence ... Read More
Inventors: Gill, Gordon N.; Wu, Rui-Yun;, Assignee: The Regents of the University of California (Oakland, CA) |
Methods of using polypeptides encoding transcriptional activators
OF THE INVENTION The invention provides a purified polypeptide having substantially the same amino acid sequence and activity as the protein having the amino acid sequence of FIG. 1, or a characteris... Read More
Inventors: Maki, Richard A.; Klemsz, Michael J.; McKercher, Scott R.; Celada, Antonio;, Assignee: La Jolla Cancer Research Foundation (La Jolla, CA) |
Antihelminthic anthraquinones and method of use thereof
OF THE INVENTION All patents, patent applications, government publications, government regulations, and literature references cited in this specification are hereby incorporated herein by reference i... Read More
Inventors: Cichewicz, Robert H.; Nair, Muraleedharan G.; McKerrow, James H.;, Assignee: Board of Trustees of Michigan State University (East Lansing, MI); The Regents of the University of California (Oakland, CA) |
Method for stimulating an immune response
It is therefore an object of the present invention to provide a method for stimulating a directed immune response in cells of a living organism. More specifically, it is an object of the invention to ... Read More
Inventors: Cezayirli, Cem; Silvers, Mel;, Assignee: |
Vector systems for the generation of adeno-associated virus particles
What is claimed: 1. A vector system for enhanced production of infectious adeno-associated virus particles comprising: a first vector, said first vector being an adeno-associated viral vector, said fi... Read More
Inventors: Chiorini, John A.; Kotin, Robert; Safer, Brian; Urcelay, Elena;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Multi-portion antiperspirant composition
OF THE INVENTION The following definitions will apply throughout the specification and claims to the terms set out below: "Anhydrous" means substantially free (that is, contains less than about 2%, p... Read More
Inventors: Elliott, David L.; Colwell, Dennis J.; Sane, Jayant N.; Vu, Tuan M.; Galante, Cheryl Lynn;, Assignee: The Gillette Company (Boston, MA) |
Fluorogenic substrates for measurement of lysosomal enzyme activities within intact cells
OF THE INVENTION The fluorogenic substrates of the present invention include 2,3-dicyano-hydroquinone (DCH) derivatives of the following formula: ##STR2## wherein R is a moderately basic acyclic, cyc... Read More
Inventors: Miller, Stephen P. F.; Brady, Roscoe O.;, Assignee: The United States of America as represented by of the Department of (Washington, DC) |
Novel phosphorylmuramyl peptides and processes for the manufacture thereof
What is claimed is: 1. Pharmaceutical preparation with antiobiotic activity for parenteral or enteral administration which contains an antibiotically effective combination of at least one antibiotic a... Read More
Inventors: Baschang, Gerhard; Tarcsay, Lajos; Hartmann, Albert; Stanek, Jaroslav;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Phosphoryl compounds, pharmaceutical preparations containing such compounds, and their use
We claim: 1. Hexopyranose compounds of the formula I, ##STR25## in which the hexopyranose is D-glucose, D-galactose or D-mannose, each of X.sup.1 and X.sup.2, independently of the other, represents a ... Read More
Inventors: Baschang, Gerhard; Hartmann, Albert; Wacker, Oskar; Tarcsay, Lajos;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
An improved method of treating sickle cell anemia
OF THE DISCLOSED EMBODIMENT The present invention comprises a composition which provides a synergistic action in lysing blood clots and reestablishing and maintaining blood flow through a thrombosed ... Read More
Inventors: Hunter, Robert L.; Duncan, Alexander;, Assignee: Emory University (Atlanta, GA) |
Stabilization of antibodies
I claim: 1. Stable aqueous solution of antibodies, comprising antibodies and at least one polyoxypropylene-polyoxyethylene block polymer and at least one phospholipid in amounts effective to prevent t... Read More
Inventors: Jansen, Theodorus; Janssen, Engelbertus J. M.; Cornelius, Lammert;, Assignee: Akzo N.V. (Arnhem, NL) |
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Gene Therapy 
