Human RNA binding proteins
What is claimed is: 1. An isolated and purified polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:1. 2. An isolated and purified polynucleotide having a sequence wh... Read More
Inventors: Bandman, Olga; Tang, Y. Tom; Corley, Neil C.; Guegler, Karl J.; Lu, Dyung Aina M.; Baughn, Mariah R.;, Assignee: Incyte Pharmaceuticals, Inc. (Palo Alto, CA) |
Method for the identification of peptides that recognize specific DNA sequences
Disclosed herein is a unique strategy for identifying biologically significant peptide-DNA binding interactions. A first aspect of the present invention is a method for identifying sequence-specific D... Read More
Inventors: Cheng, Xiaojun; Juliano, R. L.;, Assignee: The University of North Carolina at Chapel Hill (Chapel Hill, NC) |
Detection of APC proteins
It is an object of the present invention to provide a method for diagnosing and prognosing a neoplastic tissue of a human. It is another object of the invention to provide a method of detecting geneti... Read More
Inventors: Albertsen, Hans; Anand, Rakesh; Carlson, Mary; Groden, Joanna; Hedge, Philip John; Joslyn, Geoff; Kinzler, Kenneth; Markham, Alexander Fred; Nakamura, Yusuke; Thliveris, Andrew; Vogelstein, Bert; White, Raymond L.;, Assignee: The Johns Hopkins University (); University of Utah (); The Cancer Institute (JP); Imperial Chemical Industries PLC (GB) |
Peptides and nucleic acid sequences related to the Epstein Barr virus
OF THE INVENTION The term "peptide" as used herein refers to a molecular chain of amino acids with a biological activity, and does not refer to a specific length of the product. Thus inter alia, prot... Read More
Inventors: Middeldorp, Jaap M.; van Grunsven, Wouterus M. J.;, Assignee: Akzo Nobel, N.V. (Arnhem, NL) |
Mammalian expression vectors
The present invention provides a vector system that allows the rapid and effective screening of recombinant constructs by the use of a novel vector. The vector comprises; a) a cDNA structural gene se... Read More
Inventors: Smith, John M.; Humphrey, John E.; Tsang, Monica L.; Weatherbee, James A.;, Assignee: Research & Diagnostics Systems, Inc. (Minneapolis, MN) |
Process for the preparation of instant cooking alimentary paste
I claim: 1. A method of preparing instant-cooking alimentary paste, comprising the following steps: (a) introducing a mixture of cereal flour and water into an extrusion zone to form a paste, and stea... Read More
Inventors: Braibanti, Ennio;, Assignee: Dott. Ingg. M., G. Braibanti & C. S.p.A. (IT) |
Water-soluble mixed ethers of .beta.-cyclodextrin and a process for their preparation
What is claimed is: 1. A water-soluble mixed ether of .beta.-cyclodextrin wherein each ether substituent is a member selected from the group consisting of C.sub.1 and C.sub.2 alkyl, hydroxy(C.sub.2 to... Read More
Inventors: Brandt, Lothar; Felcht, Utz-Hellmuth;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Separation and purification of cyclodextrins
What is claimed is: 1. A method for sequentially separating different cyclodextrins from a solution containing said different cyclodextrins comprising the steps of: (a) passing the solution containing... Read More
Inventors: Beesley, Thomas E.;, Assignee: American Maize-Products Company (Stamford, CT) |
Anti-inflammatory furanones
What is claimed is: 1. A compound of the formula: ##STR8## in which: the dotted line represents absence of a bond or a single bond; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl, C.sub.1 -C.sub.... Read More
Inventors: Lee, Gary C. M.; Garst, Michael E.; Bonfiglio, John N.; Syage, Elizabeth T.;, Assignee: Allergan, Inc. (Irvine, CA) |
Cyclodextrin polymers and cyclodextrins immobilized on a solid surface
OF THE INVENTION The invention is directed to a polyionic derivative of a cyclodextrin polymer or a polyionic derivative of at least one cyclodextrin immobilized on a solid surface. The invention is ... Read More
Inventors: Weisz, Paul B.; Shing, Yuen W.;, Assignee: The Trustees of the University of Pennsylvania/Childrens Hospital (Philadelphia, PA) |
Pharmaceutical formulations for parenteral use
OF THE INVENTION The term "lipophilic" is used herein to describe drugs which are lipid-soluble and hydrophobic, i.e. which are insoluble or sparingly soluble in water. The expression "parenteral" as... Read More
Inventors: Bodor, Nicholas S.;, Assignee: University of Florida (Gainesville, FL) |
Automatic dishwashing compositions comprising quaternary substituted bleach activators
OF THE INVENTION Preferred ADD compositions of this invention are substantially free of chlorine bleach. By "substantially free" of chlorine bleach is meant that the formulator does not deliberately ... Read More
Inventors: Taylor, Lucille Florence; Sivik, Mark Robert; Willey, Alan David; Burckett-St. Laurent, James Charles Theophile; Hartman, Frederick Anthony;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Antitartar composition and its use in food supplements for animals
OF THE INVENTION In accordance with the invention, the expression "to control tartar" means not only to avoid or limit the formation of tartar but also to destroy tartar, which has already formed. Th... Read More
Inventors: Cyr, Jean-Paul; Denoun, Jean-Marc;, Assignee: Societe a Responsabilite Limitee (Naintre, FR) |
Chitin extract for treatment of skin disease
OF A PREFERRED EMBODIMENT I. Preparation of CSE In general, CSE was prepared from commercially available chitin (Fluka, Sigma) as described in U.S. Pat. No. 4,701,444. A CSE composition for cosmetic ... Read More
Inventors: Segal, Esther; Brenner, Sarah;, Assignee: Ramot University Authority for Applied Research and Industrial (Ramat-Aviv, IL) |
Biocompatible polyester and production thereof
The object of the present invention is to improve the hydrolyzability in vivo of a biocompatible polyester and to provide a biocompatible polyester having desired hydrolyzability which is suitable for... Read More
Inventors: Shinoda, Hosei; Ohtaguro, Masami; Iimuro, Shigeru;, Assignee: Mitsui Toatsu Chemicals, Inc. (Tokyo, JP) |
Compositions containing a mixture of phosphorus compounds and alkylglycerols
I claim: 1. A tumor inhibiting, therapeutic composition comprising: a. oleylphosphocholine or a physiologically acceptable salt thereof; b. an ethylglycerol ether or a propylglycerol ether, c. a penty... Read More
Inventors: Eibl, Hansjorg;, Assignee: Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften (Gottingen, DE) |
Process for the preparation of taxol and 10-deacetyltaxol
OF THE INVENTION The present invention is based in part on the discovery that the xyloside moiety of a taxane-7-xyloside can be oxidatively cleaved by the use of sodium periodate or other periodates ... Read More
Inventors: Rao, Koppaka V.;, Assignee: University of Florida (Gainesville, FL) |
IGF-1 analogs
OF INVENTION Synthetic peptides of less than 25 amino acids are provided which are capable of inhibiting cell proliferation. Initial synthetic analogs were designed to incorporate the amino acid sequ... Read More
Inventors: Jameson, Bradford A.; Baserga, Renato;, Assignee: Thomas Jefferson University (Philadelphia, PA) |
Compositions and methods for modulating growth of a tissue in a mammal
OF THE INVENTION The invention is directed to compounds, compositions and methods for affecting the growth of living tissue in mammals. The novel compounds of the present invention are derivatized cy... Read More
Inventors: Herrmann, Howard C.; Barnathan, Elliot; Weisz, Paul B.;, Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA) |
Regioselective substitutions in cyclodextrins
OF THE INVENTION Herein we disclose the use of controlled basic reaction conditions to provide directed substitution at specific sites: (1) toward hydroxyls 2 or 2,3 of glucose residues with little s... Read More
Inventors: Pitha, Josef; Lindberg, Bengt;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Substituted cyclodextrins and process for chromatographic separation of chiral organic compounds
We claim: 1. A substituted cyclodextrin of the formula ##STR3## in which R.sup.2, R.sup.3 and R.sup.6 each independently is an alkyl or alkenyl group having 1 to 8 carbon atoms, or a cycloalkyl group ... Read More
Inventors: Konig, Wilfried; Wenz, Gerhard; Lutz, Sabine; von der Bey, Eva;, Assignee: Macherey-Nagel & Co. (Duren-Rolsdorf, DE) |
Process for the preparation of a 2-substituted 3,3-difluorofuran
I claim: 1. A process for the preparation of a 2',2'-difluoronucleoside which comprises: reacting a 2-ketonucleoside of the formula ##STR16## with diethylammonium sulfur trifluoride (DAST) in the pres... Read More
Inventors: Kjell, Douglas P.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
OF THE INVENTION The stability of the prodrug has always been limited by the occurrence of precipitation in the product. This precipitation has been related to the degradation of prodrug to phenytoin... Read More
Inventors: Herbranson, Dale E.; Speicher, Earl R.; Rosenberg, Leonard S.;, Assignee: E. I. Du Pont de Nemours and Company (Wilmington, DE) |
Phospholipid and propylene glycol based lubricant
OF THE INVENTION Throughout this specification, unless the context requires otherwise, the word "Comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusio... Read More
Inventors: Hills, Brian Andrew;, Assignee: MacNaught Medical Pty Limited (Turrella, AU) |
1,7-Octadiene process
What is claimed is: 1. A process for preparing 1,7-octadiene which comprises hydrodimerizing butadiene in the presence of formic acid or a salt of formic acid, optionally a solvent, a catalytic amount... Read More
Inventors: Nozaki, Kenzie;, Assignee: Shell Oil Company (Houston, TX) |
Production of 1,7-octadiene from butadiene
What is claimed is: 1. In the process for preparing 1,7-octadiene by hydrodimerizing 1,3-butadiene in the presence of a solubilized palladium catalyst, a tertiary phosphine, formic acid, a base and op... Read More
Inventors: Nozaki, Kenzie;, Assignee: Shell Oil Company (Houston, TX) |
Process for preparing phosphinyloxy propanaminium inner salt derivatives
What is claimed is: 1. A process for preparing a compound of the formula: ##STR18## where X.sub.1 and X.sub.2 are independently O or S, and R.sub.1 is R.sub.5 --Y--R.sub.6 or R.sub.7 --Z--R.sub.8, whe... Read More
Inventors: Prashad, Mahavir; Kapa, Prasad K.;, Assignee: Sandoz Ltd. (Basel, CH) |
Vulcanizable partially hydrogenated nitrile rubber composition containing partially hydrogenated unsaturated nitrile-conjugated diene copolymer sulfur vulcanizer and tellurium dithiocarbamate vulcanization promotor
What is claimed is: 1. A vulcanizable rubber composition comprising a partially hydrogenated unsaturated nitrile-conjugated diene copolymer having an iodine value of 10 to 25, wherein said partially h... Read More
Inventors: Hayashi, Sachio; Miyauchi, Isamu; Oyama, Motofumi;, Assignee: Nippon Zeon Co., Ltd. (Tokyo, JP) |
Use of a thromboxane receptor antagonist in pregnancy-induced hypertension and related conditions
I claim: 1. A method of treatment of a pregnant female subject for combatting pregnancy-induced hypertension, preeclampsia, eclampsia or intrauterine growth retardation, either by therapy or prophylax... Read More
Inventors: Humphrey, Patrick P. A.;, Assignee: Glaxo Group Limited (London, GB2) |
Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredients
What we claim is: 1. Inclusion complex of 7-isopropoxy-isoflavon formed with any kind of cyclodextrin. 2. Inclusion complex of 7-isopropoxy-isoflavon formed with .alpha.-cyclodextrin as defined in cla... Read More
Inventors: Stadler nee Szoke, Agnes; Szejtli, Josef; Weiszfeiler, Viktor; Vargay, Zoltan; Kaloy, Katalin; Gergely, Vera; Szuts, Tamas;, Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T. (Budapest, HU) |
Gene Therapy 
