Acetophenone intermediates
OF THE INVENTION Referring to the five reaction steps under the "Summary of the Invention" section, this invention can be understood by considering the following detailed description. The process of ... Read More
Inventors: Brown, Richard W.;, Assignee: Imperial Chemical Industries plc (Millbank, GB3) |
Methods for inhibiting bone loss
OF THE INVENTION The current invention concerns the discovery that a group of 2-phenyl-3-aroylbenzothiophenes (benzothiophenes) of formula I are useful in the treatment of osteoporosis. The benzothio... Read More
Inventors: Black, Larry J.; Cullinan, George J.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
N-acyl pyrrolidines and drugs for the treatment or prevention of cholecystokinin and gastrin-related disorders
We claim: 1. A compound of formula (I): ##STR16## in which: R represents a hydrogen atom or an alkyl, cycloalkyl or phenylalkyl radical or a phenyl radical optionally substituted by at least one subst... Read More
Inventors: Capet, Marc; Dubroeucq, Marie-Christine;, Assignee: Rhone-Poulenc Rorer, S.A. (Antony, FR) |
Cationized carriers for immunogen production
We claim: 1. A physiologically soluble conjugate of a carrier and an antigen, said antigen having a molecular weight of 5,000 or more and which itself can elicit an immune response, said carrier being... Read More
Inventors: Domen, Patricia L.; Hermanson, Greg;, Assignee: Pierce Chemical Company (Rockford, IL) |
Translation driver system and methods for use thereof
OF THE INVENTION The present invention provides methods and products based on the achievement of translation from monocistronic or multicistronic RNAs in eukaryotic cells. In preferred embodiments, t... Read More
Inventors: Hentze, Matthias W.; De Gregorio, Ennio;, Assignee: Anadys Pharmaceuticals, Inc. (San Diego, CA) |
5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressants
OF THE INVENTION As used herein the term "halogen" refers to monovalent iodine, bromine, chlorine or fluorine radicals, the term "nitrogen" refers to a trivalent nitrogen radical and the term "CH gro... Read More
Inventors: Wolos, Jeffrey A.; Doherty, Niall S.; Jarvi, Esa T.; McCarthy, James R.;, Assignee: Merrell Dow Pharmaceuticals Inc. (Cincinnati, OH) |
Pharmaceutical composition of cyclandelate having a high degree of bioavailability
One object of the present invention is to provide a novel pharmaceutical composition which possesses a high degree of bioavailability. Another object of the present invention is to facilitate the abso... Read More
Inventors: Motoyama, Shimesu; Sato, Satoshi; Umeda, Seiichi; Yasumi, Hirotsune; Sudo, Emiko; Tsujino, Takuichi; Akazawa, Akira;, Assignee: Freund Industrial Company, Ltd. (Tokyo, JP) |
Agent for treating heart disease
What is claimed is: 1. An encapsulated heart medication composition for increasing fluidity of circulating blood, said composition comprising from about 200 to about 800 mg vitamin E, nifedipine, and ... Read More
Inventors: Ismail, Roshdy;, Assignee: |
Method for the treatment of protoza infections with 2.sup.1 -deoxy-2.sup.1 -fluoropurine nucleosides
We claim: 1. A method of treating a Trichomonas vaginalis infection in a mammal in need thereof which comprises administering to said mammal a therapeutically effective amount of the compound selected... Read More
Inventors: Tisdale, Sylvia M.; Van Tuttle, Joel; Slater, Martin J.; Daluge, Susan M.; Miller, Wayne H.; Krenitsky, Thomas A.; Koszalka, George W.;, Assignee: Burroughs Wellcome Co. (NC) |
Hygromycin A derivatives
OF THE INVENTION The preparation of the compounds of the present invention is illustrated in the following Scheme. ##STR5## The compounds of the present invention are readily prepared. With reference... Read More
Inventors: Hayward, Mathew Merrill;, Assignee: Pfizer Inc (New York, NY) |
Wavelength-specific cytotoxic agents
We claim: 1. A conjugate of the formula Ig-L-Gp or Re*-L-Gp, wherein Ig represents an immunoglobulin or an immunologically reactive portion thereof, wherein Re* represents a ligand specific for a rece... Read More
Inventors: Levy, Julia G.; Dolphin, David; Chow, Jack J.; Sternberg, Ethan;, Assignee: University of British Columbia (Vancouver, CA) |
Surface fluorescent monitor
What is claimed is 1. A hand held fluorometer comprising: a housing having a conical portion; an optical fiber connector located in a wall of said housing for connecting said hand held fluorometer to ... Read More
Inventors: Friauf, Walter S.; Smith, Paul D.; Cole, John W.; Fessler, Joseph F.; Solomon, Roger E.; Bernstein, Eric F.;, Assignee: The United States of America as represented by the Secretary of the (Washington, DC) |
Modified bioluminescent proteins and their use
What is claimed is: 1. A modified bioluminescent protein selected from the group consisting of firefly luciferase, aequorin and obelin, modified to include an interaction site for a selected analyte, ... Read More
Inventors: Campbell, Anthony Keith;, Assignee: University of Wales College of Medicine (Cardiff, GB) |
Quaternary 6,11-dihydro-dibenzo-[b,e]-thiepine-11-N-alkylnorscopine ethers having spasmolytic activity
We claim: 1. A compound of the formula ##STR6## wherein R is a linear or branched alkyl having from 1 to 10 carbon atoms and X.sup.(-) is a non-toxic, pharmacologically acceptable anion. 2. The compou... Read More
Inventors: Banholzer, Rolf; Bauer, Rudolf;, Assignee: Boehringer Ingelheim KG (Ingelheim am Rhein, DE) |
Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
We claim: 1. A compound of the formula ##STR26## wherein Q is a group of the formula --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or ##STR27## R and R' are each independently C.sub.1 -C.sub.4 -alkyl; R.sub... Read More
Inventors: Banholzer, Rolf; Bauer, Rudolf; Reichl, Richard;, Assignee: Boehringer Ingelheim GmbH (Ingelheim am Rhein, DE) |
Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
We claim: 1. A compound of formula ##STR29## wherein R is an optionally halo- or hydroxy-substituted C.sub.1-4 -alkyl group; R' is a C.sub.1-4 -alkyl group; or R and R' together form a C.sub.4-6 -alky... Read More
Inventors: Banholzer, Rolf; Bauer, Rudolf; Reichl, Richard;, Assignee: Boehringer Ingelheim KG (Ingelheim am Rhein, DE) |
Device for producing high pressure in a fluid in miniature
We claim: 1. A device for atomizing fluid, comprising: a housing having an upper housing part and a lower housing part; a pump housing disposed in said upper housing part; a nozzle disposed at one end... Read More
Inventors: Jaeger, Joachim; Cirillo, Pasquale; Eicher, Joachim; Geser, Johannes;, Assignee: Boehringer Ingelheim GmbH (DE) |
In vivo selection of microbial virulence genes
Accordingly, it is an object of this invention to provide a method for the identification of microbial genes that are specifically induced within the host tissues. Additional objects, advantages and n... Read More
Inventors: Mahan, Michael J.; Mekalanos, John J.; Slauch, James M.;, Assignee: President and Fellows of Harvard College (Cambridge, MA) |
Soybean variety 93B53
OF THE INVENTION A soybean variety needs to be highly homogeneous, homozygous and reproducible to be useful as a commercial variety. There are many analytical methods available to determine the homoz... Read More
Inventors: Steiger, Debra Kay; Streit, Leon George; Grace, III, Dorman John;, Assignee: Pioneer Hi-Bred International, Inc. (Des Moines, IA) |
Piperazides of substituted phenylalanine derivatives as thrombin inhibitors
We claim: 1. D,L-, L- or D-phenylalanine piperazides of formula ##STR15## wherein R.sup.1 represents a basic group of formula ##STR16## R.sup.2 represents an (un)substituted aryl or heteroaryl residue... Read More
Inventors: Stuerzebecher, Joerg; Vieweg, Helmut; Wikstroem, Peter; Adler, Christoph;, Assignee: Pentapharm AG (Basel, CH) |
Process for the preparation of (aryl)-(dimethyl)-(3-(4-fluoro-3-aryloxyphenyl)propyl)silanes
I claim: 1. A process for the preparation of a compound of formula I ##STR12## in which: R.sup.1 is hydrogen, halogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy; and R.sup.2 is hydrogen, h... Read More
Inventors: Schubert, Hans H.;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Method for generating and screening useful peptides
A method is provided for inexpensively and rapidly producing a large and varied population of peptides, up to nearly all theoretically possible peptides in a particular size range, according to amino ... Read More
Inventors: Venton, Duane L.; Hopfinger, Anton J.; Le Breton, Guy;, Assignee: Receptor Laboratories, Inc. (Chicago, IL) |
Method and apparatus for detecting a blood clot
OF THE FIGURES Referring to FIG. 1, there is shown a diagrammatic illustration of the phases of a blood sample in a basic system for detecting the formation of a fibrin clot. Numeral 1 represents a b... Read More
Inventors: Mintz, Michael;, Assignee: International Technidyne Corp. (Edison, NJ) |
IL-6 mutein and DNA encoding thereto
What is claimed is: 1. A polypeptide comprising the amino acid sequence of SEQ ID NO:1. 2. A DNA molecule comprising the DNA sequence coding for the polypeptide of claim 1. 3. A vector comprising the ... Read More
Inventors: Ehlers, Marc; Rose-John, Stefan; Grotzinger, Joachim;, Assignee: Applied Research Systems ARS Holding N.V. (Curacao, NL) |
Microbiological assay pad and kit for selective detection of toxicants
OF THE INVENTION The biological assay of the subject invention selectively detects the presence of heavy metals in an environmental sample. The sample can be, for example, water, soil, sediment, or a... Read More
Inventors: Bitton, Gabriel; Koopman, Ben;, Assignee: University of Florida Research Foundation, Inc. (Gainesville, FL) |
Hydrophilic nitrite copolymers
We claim: 1. A composition comprising a hydrophilic copolymer having reactive -C.tbd.N groups, which contains (A) 2 - 50 mol. percent of methacrylonitrile or acrylonitrile and (B) 50 - 98 mol. percent... Read More
Inventors: Vacik, Jiri; Kopecek, Jindrich;, Assignee: Ceskoslovenska akadamie ved (Prague, CS) |
Method and apparatus for applying synthetic resin powder in a grate-shaped coating to web material
Starting from the mentioned German petty patent the present invention contemplates a method for applying synthetic resin powder in a grate-shaped coating to web material composed of textile fibers whe... Read More
Inventors: Caratsch, Hans-Peter;, Assignee: |
Process for reducing the coefficient of friction in regenerated cellulose sausage casings
What is claimed is: 1. A process for preparing linked meat filled sausage casings of regenerated cellulose having uniform dimensional characteristics which comprises applying to the external walls of ... Read More
Inventors: Judd, Henry E.; Talty, Robert D.;, Assignee: Teepak, Inc. (Chicago, IL) |
Quick action flow regulator for medical apparatus
The present invention is concerned with a flow regulator for use in medical apparatus in which flow of fluid can be quickly adjusted in either direction and can thereafter be adjusted more precisely. ... Read More
Inventors: Bellin, Matthew E.; Marino, Jr., Joseph A.;, Assignee: |
Coupling connectors for respirator masks
It is an object of the invention to eliminate or minimise these shortcomings and to this end relates to a coupling connector of the kind which may be attached to and detached from the snout of a respi... Read More
Inventors: Biard, Jacques;, Assignee: Fenzy S.A. (Montreuil, FR) |
Gene Therapy 
