Method of treating adult respiratory distress syndrome
OF THE DISCLOSED EMBODIMENTS In accordance with the present invention, a method is provided for treating pathologic hydrophobic interactions in blood and other biological fluids of humans and animals... Read More
Inventors: Hunter, Robert L.;, Assignee: Emory University (Atlanta, GA) |
Method of treating burns
OF THE DISCLOSED EMBODIMENTS In accordance with the present invention, a method is provided for treating pathologic hydrophobic interactions in blood and other biological fluids of humans and animals... Read More
Inventors: Hunter, Robert L.;, Assignee: Emory University (Atlanta, GA) |
Method for treating sickle cell disease
OF THE DISCLOSED EMBODIMENT The present invention comprises a composition which provides a synergistic action in lysing blood clots and reestablishing and maintaining blood flow through a thrombosed ... Read More
Inventors: Hunter, Robert L.; Duncan, Alexander;, Assignee: Emory University (Atlanta, GA) |
Method and composition for reducing tissue damage
OF THE DISCLOSED EMBODIMENT The present invention comprises a composition which provides a synergistic action in lysing blood clots and reestablishing and maintaining blood flow through a thrombosed ... Read More
Inventors: Hunter, Robert L.; Duncan, Alexander;, Assignee: Emory University (Atlanta, GA) |
Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
These objects are achieved by the provision of a tissue plasminogen activator (t-PA) zymogen capable of converting to the enzymatically active form of t-PA upon cleavage by plasmin. In another aspect,... Read More
Inventors: Anderson, Stephen; Bennett, William F.; Botstein, David; Higgins, Deborah L.; Paoni, Nicholas F.; Zoller, Mark J.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Dramatic simplification of a method to treat neoplastic disease by radiation
OF THE INVENTION I. Simplification of a Complex Protocol CldC and a single coadministered cytidine deaminase inhibitor, such as Tetrahydrouridine (H4U) or Zebularine (Zb), are surprisingly and unexpe... Read More
Inventors: Greer, Sheldon B.;, Assignee: |
Compounds
1. A compound of formula (II): ##STR14## where R1 is C3-5 alkyl optionally substituted by 1 or more halogen atoms; R3 and R4 are both hydroxy; R is XOH, where X is OCH2CH2, or a protected derivative t... Read More
Inventors: Hardern, David; Ingall, Anthony; Springthorpe, Brian; Willis, Paul; Guile, Simon;, Assignee: AstraZeneca AB (Sodertalje, SE) |
Calcium hypochlorite blended tablets
OF THE INVENTION The term "non-Division 5.1 Oxidizer composition" as used in the present specification and claims refers to any blend of calcium hypochlorite hydrate and magnesium sulfate heptahydrat... Read More
Inventors: Brennan, James P.; Loomis, Paul S.;, Assignee: Arch Chemicals, Inc. (Norwalk, CT) |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
OF THE INVENTION This invention relates to processes, DNA sequences, compositions of matter and transgenic mammals for the production of recombinant proteins More specifically, this invention relates... Read More
Inventors: Meade, Harry; Lonberg, Nils;, Assignee: Biogen, Inc. (Cambridge, MA) |
Methods for predicting the behaviour of breast tumours
What is claimed is: 1. A method of determining the risk of metastasis of a female breast tumour, which comprises determining whether a tissue sample from said tumour expresses a polypeptide comprising... Read More
Inventors: Manning, David Lockwood; Nicholson, Robert Ian; Gee, Julia Margaret Wendy; Green, Christopher Douglas;, Assignee: University of Wales College of Medicine (Cardiff, GB) |
Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
In a first embodiment, there is provided a method, for evaluating a biological condition of a subject, based on a sample from the subject. The method includes: deriving from the sample a profile data ... Read More
Inventors: Bevilacqua, Michael P.; Cheronis, John C.; Tryon, Victor; Bankaitis-Davis, Danute M.;, Assignee: Source Precision Medicine, Inc. (Boulder, CO) |
Functional DNA clone for hepatitis C virus (HCV) and uses thereof
The present invention advantageously provides an authentic hepatitis C virus (HCV) DNA clone capable of replication, expression of functional HCV proteins, and infection in vivo and in vitro for devel... Read More
Inventors: Rice, Charles M.; Kolykhalov, Alexander A.;, Assignee: Washington University (St. Louis, MO) |
Self-replicating RNA molecule from hepatitis C virus
OF THE DRAWINGS FIG. 1 is a schematic view of the bi-cistronic replicon RNA. The sequence deviations between the 1377/NS2-3' replicon from Lohman et al., 1999 Science 285: 110-113 and the APGK12 repl... Read More
Inventors: Kukolj, George; Pause, Arnim;, Assignee: |
Sugar modified nucleosides and oligonucleotides
What is claimed is: 1. A nucleoside having the structure: ##STR6## wherein: R.sub.2 is selected from the group consisting of H, OH, alkoxy, aralkoxy and aryloxy; R.sub.3 and R.sub.5 are independently ... Read More
Inventors: Wang, Guangyi; Ramasamy, Kandasamy; Seifert, Wilfried E.;, Assignee: ICN Pharmaceuticals (Costa Mesa, CA) |
Methods and compositions for administration of iron for the treatment of restless leg syndrome
1. A method of treating Restless Leg Syndrome, comprising administering to a subject an iron sucrose having an iron release rate greater than IDI, wherein the iron release rate is determined at a conc... Read More
Inventors: Helenek, Mary Jane; Lange, Ralf A.; Oldham, Fred B.; Tokars, Marc L.;, Assignee: Luitpold Pharmaceuticals, Inc. (Shirley, NY) |
C-reactive protein fragment with immunomodulatory activity
OF THE INVENTION Abbreviations and Definitions The abbreviations for the various common amino acids are as recommended by the IUPAC-IUB Commission on Biochemical Nomenclature, Biochem. J. 219:345 (19... Read More
Inventors: Nestor, Jr., John J.; Ho, Teresa H.; Eppstein, Deborah A.; Felgner, Philip L.; Barna, Barbara P.; Deodhar, Sharad D.;, Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof
OF THE INVENTION As mentioned above, this invention relates to water-based pharmaceutical compositions with pH values between 4.1 and 7.2 intended to promote the growth of Gram-positive bacilli and e... Read More
Inventors: Zeng, Zhongming;, Assignee: Shanghai Jiao Da Onlly Co., Ltd. (Shanghai, CN) |
Method of preparing a lipoprotein modified by incorporation of a lipophilic active substance
OF THE PREFERRED EMBODIMENTS The method according to the invention may also have the characteristics to be described below, taken separately or in combination. The lipophilic active substance which m... Read More
Inventors: Favre, Gilles; Duriez, Patrick; Monard, Francoise; Medhi, Samadi-Baboli; Soula, Georges; Fruchart, Jean-Charles;, Assignee: Universite Droit et Sante Lille II (Lille, FR); Universite Paul Sabatier Toulouse III (Toulouse, FR) |
Microemulsions used as vehicles for carrying chemotherapeutic agents to neoplastic cells
What is claimed is: 1. A method for treating neoplasms, wherein cells from said neoplasms have an increased number of LDL receptors compared to normal cells, comprising: binding apolipoprotein E in th... Read More
Inventors: Maranh ao, Raul C.;, Assignee: Zerbini; Fundac ao E. J. (S ao Paulo, BR) |
Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
OF THE INVENTION The term "pharmaceutically acceptable salt" within the context of vinorelbine is meant to indicate that the active ingredient vinorelbine is present in the pharmaceutical composition... Read More
Inventors: Bougaret, Joel; Leverd, Elie; Bohn, Marie-Madeleine; Heintz, Norbert;, Assignee: R.P. Scherer Technologies, Inc. (Las Vegas, NV) |
Connective tissue growth factor (CTGF) regulatory nucleic acid sequences
Various cell types produce and secrete PDGF and PDGF-related molecules. In an attempt to identify the type of PDGF dimers present in the growth media of cultured endothelial cells, a new growth factor... Read More
Inventors: Grotendorst, Gary R.; Bradham, Jr., Douglass M.;, Assignee: University of South Florida (Tampa, FL) |
Process for producing humanized chimera antibody
The present invention relates to a process for producing humanized chimera antibody which comprises the steps of: (1) constructing a cassette vector by inserting a cDNA coding for human antibody CH in... Read More
Inventors: Shitara, Kenya; Hanai, Nobuo; Hasegawa, Mamoru; Miyaji, Hiromasa; Kuwana, Yoshihisa;, Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP) |
Methylation analysis using nicking agents
OF THE INVENTION The present invention provides simple and efficient methods for characterizing nucleic acid methylation states using nicking agents. Prior to providing a detailed description of the ... Read More
Inventors: Van Ness, Jeffrey; Galas, David J.; Van Ness, Lori K.;, Assignee: Keck Graduate Institute (Claremont, CA) |
Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
OF THE INVENTION The present invention provides a method for treating injury or degeneration of retinal ganglion cells by administering a therapeutically effective amount of glial cell line-derived n... Read More
Inventors: Yan, Qiao; Louis, Jean-Claude;, Assignee: Amgen Inc. (Thousand Oaks, CA) |
Fluorescent proteins
In view of the needs of the prior art, the present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid ... Read More
Inventors: Stubbs, Simon Lawrence John; Jones, Anne Elizabeth; Michael, Nigel Paul; Thomas, Nicholas;, Assignee: Amersham plc (Amersham, GB) |
Engineered cells producing insulin in response to glucose
The present invention is intended to address such disadvantages present in the prior art. In general, the invention is based on the inventor's discovery that recombinant DNA technology and cell cultur... Read More
Inventors: Newgard, Christopher B.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
DNA molecules encoding vascular endothelial cell growth factor II subunits
Vascular endothelial cell growth factor II is purified from the culture media used to maintain mammalian glioma cells. The protein is a heterodimer and stimulates mitogenesis of mammalian vascular end... Read More
Inventors: Bayne, Marvin L.; Conn, Gregory L.; Thomas, Jr., Kenneth A.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Method for cryopreserving heart valves
OF THE PREFERRED EMBODIMENT The present invention is a method of freezing, storing and thawing collagen-rich tissue, such as heart valves, with a cell-viability of at least 70% after thawing. The col... Read More
Inventors: McNally, Robert T.; Heacox, Albert; Brockbank, Kelvin G. M.; Bank, Harvey L.;, Assignee: CryoLife, Inc. (Atlanta, GA) |
Method for cryopreserving blood vessels
The device of the present invention is a structure for supporting and distending a blood vessel while permitting fluids to infiltrate the vessel to facilitate cryopreservation. More particularly discl... Read More
Inventors: McNally, Robert T.; McCaa, Cameron; Brockbank, Kelvin G. M.; Heacox, Albert E.; Bank, Harvey L.;, Assignee: CryoLife Inc. (Marietta, GA); Medical Univ. of South Carolina (Marietta, GA) |
Treated tissue for implantation and methods of treatment and use
The invention described herein includes a transplantable bioprosthetic graft tissue which is treated prior to transplant with a growth factor and then exposed to cells which are attracted into the tis... Read More
Inventors: Orton, E. Christopher;, Assignee: Colorado State University Research Foundation (Fort Collins, CO) |
Gene Therapy 
