Method for processing and preserving collagen-based tissues for transplantation
What is claimed: 1. A method for processing collagen-based tissue for transplantation comprising: (a) procuring said collagen-based tissue and placing said collagen-based tissue into a stabilizing sol... Read More
Inventors: Livesey, Stephen A.; del Campo, Anthony A.; Nag, Abhijit; Nichols, Ken B.; Coleman, Christopher;, Assignee: LifeCell Corporation (The Woodlands, TX) |
Method of preparing transplant tissue to reduce immunogenicity upon implantation
OF THE INVENTION Depending on the type of transplant intended, if the recipient is human, the initial transplant tissue or organ may be of non-human origin. These tissues or organs may be obtained at... Read More
Inventors: Goldstein, Steven;, Assignee: Cryolife, Inc. (Marietta, GA) |
Treated tissue for implantation and methods of preparation
OF THE INVENTION Depending on the type of transplant intended, if the recipient is human, the initial transplant tissue or organ may be of non-human origin. These tissues or organs may be obtained at... Read More
Inventors: Goldstein, Steven;, Assignee: Cryolife, Inc. (Marietta, GA) |
Treated tissue for implantation and methods of preparation
OF THE INVENTION Depending on the type of transplant intended, if the recipient is human, the initial transplant tissue or organ may be of non-human origin. These tissues or organs may be obtained at... Read More
Inventors: Goldstein, Steven;, Assignee: Cryolife, Inc. (Marietta, GA) |
Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
What is claimed is: 1. A method of preparing biological implants by removing cellular components and forming an extracellular matrix, comprising the steps of: a. procuring tissue; b. fixing said tissu... Read More
Inventors: Hu, Jie;, Assignee: |
Method of preparing tissues and cells for vitrification
OF THE PREFERRED EMBODIMENT AND BEST MODE I. Description of the Perfusion Apparatus In a preferred embodiment, the apparatus incorporating the principles and features of this invention is contained i... Read More
Inventors: Fahy, Gregory M.; Khirabadi, Bijan; Okouchi, Yasumitsu; Maciag, Thomas;, Assignee: The United States of America as represented by The American National Red (Washington, DC) |
AAV2 vectors and methods
The present invention is illustrated by the following examples that are not intended to limit the invention. Example I describes construction of AAV packaging plasmids encoding altered capsid protein... Read More
Inventors: Bartlett, Jeffrey S.;, Assignee: Children's Hopital Inc. (Columbus, OH) |
Recombinant negative strand RNA virus expression systems
What is claimed is: 1. A recombinant RNA molecule comprising a binding site specific for an RNA-directed RNA polymerase derived from a respiratory syncytial virus, operatively linked to a heterologous... Read More
Inventors: Clarke, David Kirkwood; Palese, Peter M.;, Assignee: Aviron (Mountain View, CA) |
Process for refolding recombinantly produced TGF-.beta.-like proteins
We claim: 1. A process for the production of a dimeric, biologically active form of a recombinantly produced Transforming Growth Factor type .beta. (TGF-.beta.)-Iike protein selected from the group co... Read More
Inventors: Cerletti, Nico; McMaster, Gary Kent; Cox, David; Schmitz, Albert; Meyhack, Bernd;, Assignee: Ciba-Geigy Corporation (Tarrytown, NY) |
Thiol-modified hyaluronan
The present invention relates to compositions including, for example, a biscarbodiimide having an intramolecular disulfide bond. The invention inter alia also includes the following embodiments, alone... Read More
Inventors: Bulpitt, Paul C. A.; Sherwood, Charles H.; Sadozai, Khalid K.;, Assignee: Anika Therapeutics, Inc. (Woburn, MA) |
Method and apparatus for analyzing multi-channel chromatogram
However, although peak separation or resolution methods relying on the above-mentioned conventional leastsquares method are resistant to noise and suitable for practical use, a model function of any f... Read More
Inventors: Ito, Masahito; Deguchi, Kisaburo;, Assignee: Hitachi, Ltd. (Tokyo, JP) |
Method and apparatus for energy efficient drying
The present invention sets out to eliminate most of the waste of sensible energy transferred from the heat source arising with known drying methods and apparatus as described above, and to allow, for ... Read More
Inventors: Stubbing, Thomas J.;, Assignee: |
Analyte concentration determination meters and methods of using the same
Devices and methods for determining the concentration of an analyte in a physiological sample are provided. The subject devices are meters characterized by having an internal structure that includes a... Read More
Inventors: Otake, Gary;, Assignee: LifeScan, Inc. (Milpitas, CA) |
Intravascular stent and method
These and other objects are accomplished by the present invention. We have discovered an intravascular stent having a coating which includes a polymer and a therapeutic substance on the body of a sten... Read More
Inventors: Tuch, Ronald J.;, Assignee: Medtronic, Inc. (Minneapolis, MN) |
Intravasoular stent and method
These and other objects are accomplished by the present invention. We have discovered an intravascular stent having a coating which includes a polymer and a therapeutic substance on the body of a sten... Read More
Inventors: Tuch, Ronald J.;, Assignee: Medtronic, Inc. (Minneapolis, MN) |
Method for treating diseases mediated by cellular proliferation in response to PDGF,EGF,FGF and VEGF
The present invention provides a method for: (1) inhibiting new blood vessel formation that is useful for treating or preventing progression of diabetic retinopathy, cavernous haemangiomas, Kaposi's s... Read More
Inventors: Brown, Paul A.; Bursten, Stuart L.; Rice, Glenn C.; Singer, Jack W.;, Assignee: Cell Therapeutics, Inc. (Seattle, WA) |
Intraluminal stent
I have found that an intraluminal stent comprising fibrin is capable of reducing the incidence of restenosis at the site of a vascular injury and can also serve as a matrix for the local administratio... Read More
Inventors: Schwartz, Robert S.;, Assignee: Medtronic, Inc. (Minneapolis, MN) |
Automated material balance system for hydrocarbon reservoirs using a genetic procedure
The present invention, accordingly, provides a system and method of producing a material balance solution for well patterns in a hydrocarbon reservoir that automatically optimizes the fluid allocation... Read More
Inventors: McCormack, Michael D.; MacAllister, Donald J.; Stoisits, Richard F.; Scherer, Perry W.; Ma, Tuan D.;, Assignee: |
Linkage of agents to body tissue using microparticles and transglutaminase
OF THE INVENTION The invention relates in part to the discovery that microparticles with particular surface characteristics can be linked to a tissue and can thereby effect an extended period of agen... Read More
Inventors: Green, Howard; Compton, Bruce J.; Corey, George D.; Djian, Philippe;, Assignee: Pericor Science, Inc. (Boston, MA) |
Wound healing using PDGF and IGF-II
We claim: 1. A method for healing an external wound of a mammal comprising applying to said wound a wound-healing amount of a composition comprising purified platelet-derived growth factor and purifie... Read More
Inventors: Antoniades, Harry N.; Lynch, Samuel E.;, Assignee: President and Fellows of Harvard College (Cambridge, MA) |
Collagen-containing sponges as drug delivery compositions for proteins
OF THE INVENTION The present invention relates to a collagen-containing sponge comprising an absorbable gelatin sponge, collagen, and an active ingredient. An appropriate absorbable gelatin sponge is... Read More
Inventors: Song, Suk-Zu; Morawiecki, Andrew;, Assignee: Amgen Inc. (Thousand Oaks, CA) |
Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
OF PREFERRED EMBODIMENTS The present invention is directed to methods of treatment of corneal haze and pain resulting from laser irradiation of the eye. The invention also encompasses compositions wh... Read More
Inventors: Yanni, John M.;, Assignee: Alcon Laboratories, Inc. (Fort Worth, TX) |
Isolated nucleic acid encoding a newt acidic fibroblast growth factor (AFGF)
We claim: 1. A cDNA clone comprising a DNA sequence coding Notophthalmus viridescens acidic fibroblast growth factor (aFGF) as shown in Sequence ID No. 2. 2. A cDNA clone of claim 1 wherein the cDNA i... Read More
Inventors: Chiu, Ing Ming; Poulin, Matthew L.;, Assignee: The Ohio State University Research Foundation (Columbus, OH) |
Methods of wound healing and treating hyperproliferative diseases of epidermis comprising administering trunicated keratinocyte growh factor (KGF) having increased biological activity
OF THE PREFERRED EMBODIMENTS It has been surprisingly discovered that a truncated, unglycosylated KGF having a deletion spanning the first 23 N-terminal amino acid residues of mature recombinant KGF ... Read More
Inventors: Gospodarowicz, Denis J.; Masiarz, Frank R.;, Assignee: Chiron Corporation (Emeryville, CA) |
DNA molecules encoding PDGF molecules having protease resistant basic cleavage sites
Briefly stated, the present invention provides PDGF B-chain polypeptides characterized by a substitution or deletion at an amino acid position selected from the group consisting of position 27, positi... Read More
Inventors: Murray, Mark J.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
Methods and compositions for the specific coagulation of vasculature
The present invention overcomes the limitations of the prior art by providing novel compositions and methods for use in achieving specific coagulation, for example, coagulation in tumor vasculature, w... Read More
Inventors: Thorpe, Philip E.; Edgington, Thomas S.;, Assignee: Board of Regents, The University of Texas System (Austin, TX); The Scripps Research Institute (La Jolla, CA) |
Medium containing flt3 ligand for culturing hematophoietic cells
OF THE INVENTION A cDNA encoding murine flt3-L has been isolated and is disclosed in SEQ ID NO:1. A cDNA encoding human flt3-L also has been isolated and is disclosed in SEQ ID NO:5. This discovery o... Read More
Inventors: Lyman, Stewart D.; Beckmann, M. Patricia;, Assignee: Immunex Corporation (Thousand Oaks, CA) |
Crystalline form of N-acetylmuramyl-L-.alpha.-aminobutyryl-D-isoglutamine
What is claimed is: 1. Crystalline N-acetylmuramyl-L-.alpha.-aminobutyryl-D-isoglutamine monohydrate. 2. A method for making crystalline N-acetylmuramyl-L-.alpha.-aminobutyryl-D-isoglutamine monohydra... Read More
Inventors: Chan, Tai W.; Becker, Allyn R.;, Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
OF THE INVENTION EXAMPLE 1 Lecithin-coated microcrystals of oxytetracycline (OTC) were prepared by sonication in the following manner: Into a 150 ml glass beaker, 4.4 gm oxytetracycline dihydrate (Si... Read More
Inventors: Haynes, Duncan H.;, Assignee: |
Apparatus for transporting substances into living cells and tissues
Accordingly, one object of the present invention is to provide a widely applicable mechanism for transporting particles, which can comprise or be associated with biological substances, into living cel... Read More
Inventors: Sanford, John C.; Wolf, Edward D.; Allen, Nelson K.;, Assignee: Cornell Research Foundation, Inc. (Ithaca, NY) |
Gene Therapy 
