Needleless syringe using supersonic gas flow for particle delivery
What is claimed is: 1. A needleless syringe for delivering particles having a nominal particle size of at least about 10 .mu.m, said syringe comprising: an elongate tubular nozzle having upstream and ... Read More
Inventors: Bellhouse, Brian J.; Sarphie, David F.; Greenford, John C.;, Assignee: Powderject Research Limited (Oxford, GB) |
Trans-mucosal particle delivery
OF THE PREFERRED EMBODIMENTS Before describing the present invention in detail, it is to be understood that this invention is not limited to particular pharmaceutical formulations or process paramete... Read More
Inventors: Bellhouse, Brian John; Bell, John; Greenford, John Christopher; Sarphie, David Francis;, Assignee: PowderJect Research Limited (GB) |
Saratin for inhibiting platelet adhesion to collagen
OF THE INVENTION Suitable recombinant Saratin for use in the invention was expressed and isolated from Hansenula polymorpha and was found to acts by blocking vWF binding to collagen and effectively p... Read More
Inventors: Barnes, Christopher; Frech, Matthias; Hofmann, Uwe; Gleitz, Johannes; Strittmatter, Wolfgang;, Assignee: Merck GmbH (Darmstadt, DE) |
Biological pesticide
Corn rootworms are the most serious pests of corn in the major corn growing regions of North America. Root feeding of the larvae has a pronounced effect on corn growth and corn yields. Corn rootworm i... Read More
Inventors: Aronson, Arthur I.; Dunn, Peter E.;, Assignee: Purdue Research Foundation (West Lafayette, IN) |
Nucleic acid molecules from rice encoding RAR1 disease resistance proteins and uses thereof
OF THE INVENTION I. A. General Description of Trait Functional Genomics Project The goal of functional genomics is to assign functions to the genes of an organism using a variety of methodologies, in... Read More
Inventors: Sainz, Manuel B.; Salmeron, John;, Assignee: Syngenta Participations AG (Basel, CH) |
Compositions containing pipercillin and tazobactam useful for injection
1. A pharmaceutical composition comprising effective amounts of (a) piperacillin or a pharmaceutically acceptable salt thereof, (b) tazobactam or a pharmaceutically acceptable salt thereof and, (c) as... Read More
Inventors: Cohen, Jonathan Marc; Shah, Syed M.; Ofslager, Christian Luther; Fawzi, Mahdi;, Assignee: Wyeth Holdings Corporation (Madison, NJ) |
Pharmacological composition containing yeast cell wall fraction
The present invention is directed to a pharmacological composition having a yeast cell wall fraction as its active constituent (claim 1); a pharmacological composition according to claim 1, wherein th... Read More
Inventors: Shirasu, Yoshiharu; Nakamura, Tomohiko; Wakabayashi, Hideyuki;, Assignee: Kirin Beer Kabushiki Kaisha (Tokyo, JP) |
Liposome composition for the stabilization of oxidizable substances
The disadvantages and limitations of the prior art are obviated by providing an effective and efficient means of stabilizing readily oxidizable lipophilic materials. The present invention is particula... Read More
Inventors: Haynes, Lynn C.; Levine, Harry; Finley, John W.;, Assignee: Nabisco Brands, Inc. (East Hanover, NJ) |
Liposomes containing active agents aggregated with lipid surfactants
It is therefore a general object of the invention to provide a liposome composition and method for administering a therapeutically effective amount of a compound for an extended period in the bloodstr... Read More
Inventors: Needham, David;, Assignee: Duke University (Durham, NC) |
Microbubble-containing contrast agents having a non-proteinaceous crosslinked or polymerised amphiphilic shell
We claim: 1. A diagnostic ultrasound contrast agent comprising a stable dispersion in an aqueous carrier liquid of vesicles comprising microbubbles of biocompatible gas stabilized at the gas-liquid in... Read More
Inventors: Klaveness, Jo; Priebe, Hanno; Rongved, P.ang.l; Stubberud, Lars; Skurtveit, Roald; Dugstad, Harald;, Assignee: Nycomed Imaging AS (Oslo, NO) |
Composition of menthol and menthyl lactate, its preparation method and its applications as a cooling agent
OF THE INVENTION Menthol can be obtained naturally from peppermint oil, or can be synthetic. Menthol contains three asymmetrical carbon atoms. It therefore exists in 12 different stereoisomers. Howev... Read More
Inventors: Su, Evelyn G.; Wang, Chang-Guo;, Assignee: Nanjing Zhongshi Chemical Co. (Nanjing, CN) |
Automated blend reclaim system for pharmaceutical tablet compression machine
What is claimed is: 1. In combination with a pharmaceutical tablet compression machine having a bulk material container for the tablet blend mounted thereon, an automated blend waste reclaim apparatus... Read More
Inventors: Bullock, Brian C.; Nowicki, Steven R.;, Assignee: Glaxo Wellcome Inc. (RTP, NC) |
Method of modulating tumor immunity
The inventors have demonstrated that anti-lymphoma effects can be achieved in the absence of GVHD by a single injection of either viable allogeneic splenocytes or double negative regulatory T cells (D... Read More
Inventors: Zhang, Li; Young, Kevin;, Assignee: University Health Network (Toronto, CA) |
Engineered open reading frame for p53
1. An isolated nucleic acid molecule comprising a nucleotide sequence as shown in SEQ ID NO: 1. 2. A cell comprising the nucleic acid molecule of claim 1, wherein said cell is in in vitro culture. tab... Read More
Inventors: Brachmann, Rainer K.;, Assignee: Washington University (St. Louis, MO) |
Proteins with integrin-like activity
In accordance with the objects outlined above, the present invention provides structurally biased variant integrin and I domain proteins comprising amino acid sequences with at least three amino acid ... Read More
Inventors: Mayo, Stephen; Shifman, Julia; Shimaoka, Motomu; Springer, Timothy;, Assignee: California Institute of Technology (Pasadena, CA) |
Treatment of DNA viral infections
1. A method of treating DNA viral infections by administering to a patient a therapeutically effective amount of frusemide and digoxin. 2. A pharmaceutical composition for treating DNA virus infection... Read More
Inventors: Hartley, Christopher Edward;, Assignee: Henderson Morley Research and Development Limited (GB) |
Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof
1. Molecule comprising the following moiety: ##STR11## wherein R1 is C1-10 alkyl group substituted by hydroxyl, C1-4 alkoxy or halo; and R2 is hydrogen and R7 is H or a mono-, di-, tri-phosphate or th... Read More
Inventors: Fuller, Carl W.; McDougall, Mark; Kumar, Shiv;, Assignee: Amersham Biosciences Corp. (Piscataway, NJ) |
Combined hepatitis and herpesvirus antigen compositions
What is claimed is: 1. An immunogenic composition comprising: (a) a hepatitis B surface antigen (HBsAg) for inducing an immune response; and (b) a herpes simplex-2 glycoprotein D (HSV-2 gD) antigen or... Read More
Inventors: Stephenne, Jean; Wettendorff, Martine Anne Cecile;, Assignee: SmithKline Beecham Biologicals S.A. (Rixensart, BE) |
Artemisinins with improved stability and bioavailability for therapeutic drug development and application
The present invention is directed to a novel form of artemisinins that remain stable over time in solution. The artemisinins may be, but are not limited to artelinic acid and artesunic acid. This nov... Read More
Inventors: Hartell, Mark G.; Bhattacharjee, Apurba K.; Hicks, Rickey P.; VanHamont, John E.; Milhous, Wilbur K.;, Assignee: The United States of America as represented by the Secretary of the Army (Washington, DC) |
Hybrid microspheres
We claim: 1. A method of forming a coated product comprising the steps of: immersing a synthetic organic resin substrate in the form of spheres, particles, sheets, rods or tubes in an aqueous solution... Read More
Inventors: Rembaum, Alan; Yen, Richard C. K.;, Assignee: California Institute of Technology (Pasadena, CA) |
Electrodepositable coating composition containing diorganotin dicarboxylates
The ionic resin of component (a) (hereinafter referred to as "Component A", where appropriate) includes both anionic and cationic resins known to those skilled in the art. The cationic resins are pre... Read More
Inventors: Eswarakrishnan, Venkatachalam; Zwack, Robert R.; McCollum, Gregory J.; Kollah, Raphael O.; Zawacky, Steven R.;, Assignee: PPG Industries, Inc. (Pittsburgh, PA) |
Spray dried vaccine preparation comprising aluminium adsorbed immunogens
OF THE INVENTION In accordance with the present invention, immunogen-containing microspheres of the controlled- or delayed-release vaccine preparation are produced by a one-step process of manufactur... Read More
Inventors: Cox, John Cooper; Sparks, Robert Edward; Jacobs, Irwin Clay; Mason, Norbert Simon;, Assignee: CSL Limited (Parkville, AU) |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** *** NO IMAGES AVAILABLE***
Description:... Read More
Inventors: , Assignee: |
Transgenic mice expressing APC resistant factor V
We claim: 1. A transgenic mouse expressing an activated protein C (APC) resistant factor V, wherein the genome of said transgenic mouse contains a non-naturally occurring point mutation which results ... Read More
Inventors: Ginsburg, David; Cui, Jisong;, Assignee: The Regents of the University of Michigan (Ann Arbor, MI) |
Isolated nucleic acid encoding murine musculin
1. An isolated nucleic acid encoding murine musculin comprising the amino acid sequence of SEQ ID NO:2. 2. The isolated nucleic acid of claim 1 comprising a nucleotide sequence of SEQ ID NO:1. 3. A ge... Read More
Inventors: Robb, Lorraine; Begley, Glenn C.; Harvey, Richard P.;, Assignee: Walter and Eliza Hall Institute of Medical Research (AU) |
Method for nucleotide sequence amplification
OF THE INVENTION This invention is based upon the discovery that when a glycine-based osmolyte is added to a PCR amplification reaction mixture for the detection of Huntington's disease the resultant... Read More
Inventors: Miller, Glenn A.;, Assignee: Genzyme Corporation (Cambridge, MA) |
Amplification of nucleic acids
This invention generally provides methods and compositions for increasing the efficiency of amplification of nucleic acids, especially nucleic acids with high G+C content. In one aspect, a reaction mi... Read More
Inventors: Weissman, Sherman M.; Baskaran, Namadev;, Assignee: Yale University (New Haven, CT) |
Enhancement of the specificity of nucleic acid amplification by carrier nucleic acid
OF THE INVENTION The present invention is based on the finding that adding carrier nucleic acid to a nucleic acid amplification mixture considerably increases the efficiency and specificity of amplif... Read More
Inventors: Preston, Gregory M.; Backus, John W.;, Assignee: Ortho-Clinical Diagnostics, INC (Raritan, NJ) |
α-galactosidases and methods for making and using them
The invention provides an isolated nucleic acid having a sequence as set forth in SEQ ID NO.:3 and variants thereof having at least 50% sequence identity to SEQ ID NO.:3 and encoding polypeptides havi... Read More
Inventors: Murphy, Dennis; Reid, John; Robertson, Dan E.;, Assignee: Diversa Corporation (San Diego, CA) |
NF-AT polypeptides and polynucleotides and screening methods for immunosuppressive agents
The present invention provides novel methods and compositions useful, e.g., in screening for immunosuppressive agents. The invention is based in part on the discovery of the overall mechanism by which... Read More
Inventors: Crabtree, Gerald R.; Northrop, Jeffrey P.; Ho, Steffan N.; Flanagan, William M.;, Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA) |
Gene Therapy 
