Terminally-branched polymeric linkers and polymeric conjugates containing the same
In one aspect of the invention, compounds of Formula (I) are provided: ##STR6## wherein: J is ##STR7## E.sub.1-4 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyls, C.s... Read More
Inventors: Martinez, Anthony J.; Pendri, Annapurna; Greenwald, Richard B.; Choe, Yun H.;, Assignee: Enzon, Inc. (Piscataway, NJ) |
Rectally absorbable form of L-dopa
What is claimed is: 1. A method of enhancing the rate of absorption of a rectally administered composition comprising rectally administering to a patient a therapeutically effective dosage amount of a... Read More
Inventors: Repta, A. J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Rectally absorbable form of L-dopa
What is claimed is: 1. A method of enhancing the rate of absorption of a rectally administered composition comprising a therapeutically effective dosage amount of an ester of L-dopa having the structu... Read More
Inventors: Repta, A. J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Rectally absorbable form of L-dopa
What is claimed is: 1. A pharmaceutical composition for enhancing rectal absorption of L-dopa by administering a formulation comprising a therapeutically effective dosage amount of an ester of L-dopa ... Read More
Inventors: Repta, A. J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Method to treat Parkinsons disease
I claim: 1. The method of treatment of Parkinson's disease and related neurological syndromes which consists of administering by the oral or sublingual route to a patient in need of said treatment an ... Read More
Inventors: Chiesi, Paolo;, Assignee: Chiesi Farmaceutici S.p.A. (Parma, IT) |
Method of using cytoprotective alcohols to treat neural disease and neural injury
The present invention is grounded in the surprising discovery that hexacosanol and analogues and homologs thereof, including saturated and unsaturated straight chain alcohols of preferably from about ... Read More
Inventors: Borg, Jacques; Cotman, Carl W.; Kesslak, J. Patrick;, Assignee: The Regents of the University of California (Oakland, CA) |
Methods of treating Parkinson's disease using melanin
OF THE INVENTION One aspect of the present invention relates to the treatment of a mammal having a disease of a tissue which exhibits a melanin deficiency by the administration to the mammal of an ef... Read More
Inventors: Berliner, David L.; Erwin, Robert L.; McGee, David R.;, Assignee: |
Method of treating memory disorders using R-enantiomers of N-propargyl-aminoindan compounds
OF THE INVENTION The present invention thus provides as a novel compound the R(+)-enantiomer of N-propargyl-1-aminoindan [R(+)PAI] of the formula (I): ##STR1## and pharmaceutically acceptable acid ad... Read More
Inventors: Youdim, Moussa B. H.; Finberg, John P. M.; Levy, Ruth; Yellin, Haim;, Assignee: Teva Pharmaceutical Industries Ltd. (Jerusalem, IL); Technion Research and Development Foundation, Ltd. (Haifa, IL) |
L-DOPA ethyl ester to treat Parkinson's disease
OF THE INVENTION This invention provides a composition which comprises a pharmaceutically acceptable carrier and an active ingredient, such active ingredient comprising L-DOPA ethyl ester in an amoun... Read More
Inventors: Milman, Isaac; Veinberg, Alexander; Atlas, Daphne; Melamed, Eldad;, Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem, IL); Teva Pharmaceutical Industries Ltd. (Jerusalem, IL) |
Episomal vector systems and related methods
The present invention provides papilloma virus episomal vector systems and methods for papilloma virus episomal vector replication in a variety of human and animal cells not normally permissive for re... Read More
Inventors: Woo, Savio L. C.; Nordloh, Peter W.; Stenlund, Arne;, Assignee: |
Method for treating Parkinson's disease employing an ATP-sensitive potassium channel blocker
What is claimed is: 1. A method for treating Parkinson's disease, which comprises administering locally to a mammalian species in need of treatment a therapeutically effective amount of a sulfonyl ure... Read More
Inventors: Greenfield, Susan A.; Levesque, Denyse;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NY) |
Method of treatment of parkinson's disease
We claim: 1. A method of treatment of Parkinson's disease in a patient in need of such treatment, which method comprises the step of administering to said patient a therapeutically effective amount of... Read More
Inventors: Johnson, Peter; Watkins, Barry E.; Harris, Eric W.;, Assignee: Astra AB (Sodertalje, SE) |
4-aminoethoxy indolone derivatives
What is claimed is: 1. A compound of the formula I: ##STR5## in which: Y is hydrogen, halogen or alkoxy of 1 to 6 carbon atoms; R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or arylalkyl of 7 to 1... Read More
Inventors: Mewshaw, Richard Eric;, Assignee: American Home Products Corporation (Madison, NJ) |
Genetically engineered cells that produce produce L. Dopa
In one aspect, the present invention provides a process of increasing the production of dopamine in a cell, the process comprising transfecting the cell with a first expression vector that contains a ... Read More
Inventors: Kang, Un Jung; Gage, Fred H.;, Assignee: Arch Development Corporation (Chicago, IL) |
C. elegans deletion mutants
What is claimed is: 1. A nematode having null mutations in hop-1 and sel-12, said nematode having a combined maternal-effect embryonic lethality and egg laying defective phenotype, at least one of sai... Read More
Inventors: Johnson, Carl; Westlund, Bethany; Parry, Dianne;, Assignee: Axys Pharmaceuticals, Inc. (South San Francisco, CA) |
Feline hepatocyte growth factor
The invention claimed is: 1. An isolated DNA or RNA encoding a protein having an amino acid sequence as shown in SEQ ID NO: 2 or SEQ ID NO: 4. 2. A recombinant vector comprising the DNA or RNA accord... Read More
Inventors: Miyake, Masashi; Iwabuchi, Shigehiro; Suzuta, Yasuyuki;, Assignee: Nippon Zenyaku Kogyo, LTD (Fukushima, JP) |
ppRB.sup.110 -phosphoprotein the retinoblastoma susceptibility gene product
OF FIGURES FIG. 1 is the chromatogram illustrating the identification of RB proteins by immunoprecipitation with rabbit anti-RB IgG in various cell lines. Human cells such as neuroblastoma LAN-1 (Lan... Read More
Inventors: Lee, Wen-Hwa; Lee, Eva Y. - H. P.;, Assignee: The Regents of the University of California (Berkeley, CA) |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
It has now been discovered that tumor formation in a patient can be treated or prevented by administering to the patient an antigen-presenting cell(s) that is loaded with antigen encoded in RNA derive... Read More
Inventors: Nair, Smita K.; Boczkowski, David J.; Gilboa, Eli;, Assignee: Duke University (Durham, NC) |
Mutants of the RB and P53 genes
OF THE INVENTION Definitions The term "functional expression of the gene" meant to include the suppression of transcription of the gene, the degradation of the gene transcript (pre-message RNA), the ... Read More
Inventors: Fung, Yuen Kai;, Assignee: Research Development Foundation (Carson City, NV) |
Oncolytic virus therapy
OF THE INVENTION As used herein the term "human cells" means cells isolated from a human, or cultured cells that have been derived from cells isolated from a human and/or whose nucleic acid component... Read More
Inventors: Groene, William S.; Miller, Jeffrey A.; Mueller, Stephen N.;, Assignee: Wellstat Biologics Corporation (Gaithersburg, MD) |
Covalently cross-linked oligonucleotides
OF THE INVENTION In accordance with the objects of this invention novel, covalently cross-linked oligonucleotide strands are disclosed. Preferably such strands are "duplexed" or "complementary" along... Read More
Inventors: Cook, Phillip Dan; Manoharan, Muthiah; Bruice, Thomas;, Assignee: ISIS Pharmaceuticals, Inc. (Carlsbad, CA) |
Methods of inducing cancer cell death and tumor regression
The present invention provides methods of treating cancer in a patient (e.g., a mammal such as a human) in need of such treatment, comprising administering an effective amount of (1) a farnesyl protei... Read More
Inventors: Bishop, Walter R.; Brassard, Diana L.; Nagabhushan, Tattanahalli L.;, Assignee: Schering Corporation (Kenilworth, NJ) |
Injectable hyaluronic acid derivative with pharmaceuticals/cells
OF THE INVENTION The present invention concerns injectable, biocompatible and biodegradable compositions containing at least one hyaluronic acid benzyl ester derivative and/or auto-crosslinked deriva... Read More
Inventors: Radice, Marco; Pastorello, Andrea; Pavesio, Alessandra; Callergaro, Lanfranco;, Assignee: Fidia Advanced Biopolymers, SRL. (Abano Terme, IT) |
Modification of polymer surfaces and molecular immobilization by photoreaction
OF THE INVENTION To obviate disadvantages associated with the modification methods presently existing, the object of the present invention is to provide a method for modifying the surface of a polyme... Read More
Inventors: Elsner, Henrik; Mouritsen, Soren;, Assignee: Nunc A/S (Roskilde, DK) |
Wound and skin care compositions
What is claimed: 1. A composition comprising a dermatologically acceptable carrier and an effective amount of a hydroxy acid compound, present in a concentration of about 10.sup.-4 M to about 10.sup.-... Read More
Inventors: Malik, Sohail;, Assignee: Kimberly-Clark Worldwide, Inc. (Neenah, WI) |
Water treatment apparatus
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. Water purification apparatus for purifying dirty water, comprising, in combination: a... Read More
Inventors: Xylander, Kurt;, Assignee: |
Membrane cell
What we claim is: 1. A monopolar filter press electrolytic cell suitable for use in the electrolysis of an aqueous alkali metal halide solution (brine) to produce an aqueous alkali metal hydroxide sol... Read More
Inventors: Boulton, Thomas W.; Darwent, Brian J.;, Assignee: Imperial Chemical Industries Limited (London, GB2) |
Encapsulating biological active substances into erythrocytes
We claim: 1. A process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity utilizing a dialysis element having a primary compartment and a seco... Read More
Inventors: Ropars, Claude; Nicolau, Yves C.; Chassaigne, Maurice;, Assignee: Centre National de la Recherche Scientifique (CNRS) (Paris, FR); Centre Hospitalier Regional de Tours (Tours, FR); Studiengesellschaft Kohle MBH (Muelheim/Ruhr, DE) |
Flow chamber and electro-manipulator incorporating same
Accordingly, an object of the present invention is to provide a flow chamber and an electro-manipulator incorporating the same which can be operated easily, and which are capable of continuously condu... Read More
Inventors: Hibi, Tadaaki; Sugiura, Miyoji; Kano, Hiromi; Kimura, Sigeyuki; Kazami, Takeshi;, Assignee: Ntl. Inst. of Agrobiological Resources (Ibargi, JP); Nihon Bunko Kogyo Kabushiki Kaisya (Tokyo, JP) |
Electroblotting technique for transferring specimens from a polyacrylamide electrophoresis or like gel onto a membrane
What is claimed is: 1. An apparatus especially suitable for transferring a biological specimen from a polyacrylamide electrophoresis or like gel onto a support sheet by means of electroblotting, said ... Read More
Inventors: Littlehales, William J.;, Assignee: American Bionetics, Inc. (Hayward, CA) |
Gene Therapy 
