Chlamydia antigens and corresponding DNA fragments and uses thereof
In one aspect, the present invention provides purified and isolated DNA molecules that encode Chlamydia which can be used in methods to prevent, treat, and diagnose Chlamydia infection. Encoded polype... Read More
Inventors: Murdin, Andrew D.; Oomen, Raymond P.; Dunn, Pamela L.;, Assignee: Aventis Pasteur Limited (Toronto, CA) |
Methods for selecting polynucleotides encoding T cell epitopes
OF THE INVENTION The present invention relates to methods for the identification of target antigens recognized by CTLs, and the use of such antigens in immunogenic compositions or vaccines to induce ... Read More
Inventors: Zauderer, Maurice;, Assignee: University of Rochester (Rochester, NY) |
Epidermal surface antigen gene
By the molecular cloning and characterization of a human epidermal surface antigen, ESA, the present invention overcomes several of the drawbacks inherent in the prior art. The present invention also ... Read More
Inventors: Duvic, Madeleine; Schroeder, Wanda T.;, Assignee: The University of Texas System (Austin, TX) |
Method for preparing the fimbrin protein of Haemophilus influenzae
OF THE INVENTION It has been found that fimbriae, which are surface appendages, are produced by 100% of the bacteria recovered from the middle ears and nasopharynges of children with chronic otitis m... Read More
Inventors: Kolattukudy, Pappachan E.; Bakaletz, Lauren O.; Sirakova, Tatiana;, Assignee: Ohio State Research Foundation (Columbus, OH) |
Purified chitinases and use thereof
An object of the invention herein is to provide purified chitinases which can be used per se to inhibit fungi and insects that contain chitin or can be used to provide novel chitinase-producing bacter... Read More
Inventors: Harman, Gary E.; Broadway, Roxanne M.; Tronsmo, Arne; Lorito, Matteo; Hayes, Christopher K.; Di Pietro, Antonio;, Assignee: Cornell Research Foundation, Inc. (Ithaca, NY) |
Recombinant negative strand RNA virus expression systems and vaccines
Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or... Read More
Inventors: Palese, Peter; Garcia-Sastre, Adolfo;, Assignee: The Mount Sinai School of Medicine of the City University of New York (New York, NY) |
Interferon inducing genetically engineered attenuated viruses
OF THE INVENTION The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuat... Read More
Inventors: Egorov, Andrei; Muster, Thomas; Garcia-Sastre, Adolfo; Palese, Peter; Brandt, Sabine;, Assignee: Mount Sinai School of Medicine of the City University of New York (New York, NY) |
Oxime methyl ethers
OF THE INVENTION The present invention is directed to the novel compound and the use of these compounds in fragrance formulations. We have discovered that the above described oxime methyl ethers comp... Read More
Inventors: Narula, Anubhav P. S.; Mahesh, Rajamony; Pawlak, Manfred; Merritt, Patrick M.; Brooks, Clint Dee Winton;, Assignee: International Flavors & Fragrances Inc. (New York, NY) |
Recombinant DNA coding for signal peptide, selective interacting polypeptide and membrane anchoring sequence
We claim: 1. A recombinant DNA encoding a fusion polypeptide which upon expression in a Gram positive bacterium is expressed on the surface thereof, which recombinant DNA comprises (i) a first DNA fra... Read More
Inventors: St.ang.hl, Stefan; Nygren, Per-.ANG.ke; Hansson, Marianne; Uhlen, Mathias; Nguyen, Thien Ngoc;, Assignee: Pierre Fabre Medicament (Boulogne, FR) |
Methods of electrophysiological testing
OF THE INVENTION The methods of the present invention, which are described below, may be used in the system shown in the accompanying FIG. 1, in which a plurality of electrodes 10 are placed on the h... Read More
Inventors: John, E. Roy;, Assignee: |
Sensory monitoring apparatus and method
This invention provides apparatus and method for monitoring the sensory system of a patient to enable determining of the level and depth of spinal and epidural nerve blocks affecting the sympathetic a... Read More
Inventors: Barsa, John E.;, Assignee: |
Brain electrical activity analysis and mapping
One of the primary objects of the invention is to provide an improved apparatus and method for analyzing brain electrical activity and displaying a topographical map of brain electrical activity. A mo... Read More
Inventors: Raviv, Gabriel; Raviv, Gil;, Assignee: Bio-Logic Systems Corporation (Northbrook, IL) |
Electroencephalographic consciousness and anesthetic monitor
I claim: 1. A method of testing anaesthetic depth or consciousness of a subject (2) having closed eyelids, comprising the steps of applying a stimulus signal (216) of visible red light, whose intensit... Read More
Inventors: Silberstein, Richard B.;, Assignee: Swineburn Limited (Victoria, AU) |
Multiple afferent sensory stimulation device
The invention relates to a multiple afferent sensory stimulation device receiving on a prerecorded tape, a series of electronic signals which, after processing, control the placement of visual or soun... Read More
Inventors: Gleeson, III, William J.;, Assignee: |
Electroencephalographic attention monitor
This invention relates to an attention monitor. More particularly, the invention relates to a method and apparatus for monitoring the level of attention of a subject to a visual stimulus. Results from... Read More
Inventors: Silberstein, Richard B.;, Assignee: Swinburne Limited (Victoria, AU) |
Equipment for testing or measuring brain activity
The reported insensitivity of the SSVEP to cognitive processes could have been due to a number of factors. Firstly, Wilson & O'Donnell (1986, 1988) appear to have only examined the correlation between... Read More
Inventors: Silberstein, Richard B.;, Assignee: Swinburne Limited (Victoria, AU) |
Removing irregularities from seismic data caused by tube waves
It is an object of the present invention to provide a method that effectively removes the irregularities caused by tube waves. To this end the method of removing irregularities caused by tube waves fr... Read More
Inventors: Fehmers, Gijsbert Christiaan; Mulder, William Alexander; Plessix, Rene-Edouard Andre Michel;, Assignee: Shell Oil Company (Houston, TX) |
Fibrous structure and absorbent article including such a fibrous structure
OF THE PREFERRED EMBODIMENTS The diaper 100 which is shown in FIG. 1 comprises a fluid permeable cover sheet 101, a fluid impermeable cover sheet 103 and an absorption body 105 enclosed between the c... Read More
Inventors: Chihani, Thami; Cocolios, Panayotis; Coeuret, Fran.cedilla.ois; Nihlstrand, Anna; Villermet, Alain;, Assignee: SCA Hygiene Products AB (Gothenburg, SE) |
Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae
The present invention relates to the discovery that when one or more immunogens, in a pharmaceutically acceptable composition, is first administered at an early age (typically prior to 42 days of age)... Read More
Inventors: Classen, John Barthelow;, Assignee: Classen Immunotherapies, Inc. (Baltimore, MD) |
Therapeutic liposome composition and method
In one aspect, the invention includes a method of liposome-based therapy for a mammalian subject which includes systemically administering to the subject, liposomes with outer surfaces that contain (i... Read More
Inventors: Martin, Francis J.; Zalipsky, Samuel; Huang, Shi Kun;, Assignee: Sequus Pharmaceuticals, Inc. (Menlo Park, CA) |
Polymer-lipid conjugate for fusion of target membranes
In one aspect, the invention includes a polymer-lipid conjugate for use in promoting fusion between target membranes, comprising a first segment composed of a hydrophilic polymer and a second segment ... Read More
Inventors: Martin, Francis J.; Zalipsky, Samuel;, Assignee: Sequus Pharmaceuticals, Inc. (Menlo Park, CA) |
Vitamin E conjugates
The present invention provides vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. In one aspect, the invention provides vitamin E conjugates. The vitami... Read More
Inventors: Lal, Manjari; Zhang, Yuehua; Palepu, Nagesh;, Assignee: Sonus Pharmaceuticals, Inc. (Bothell, WA) |
Agent for use as an anti-irritant
I claim: 1. A method for preventing or treating irritation or itching of the skin, which comprises the topical administration to the skin of a composition containing, as an active ingredient, an effec... Read More
Inventors: Cauwenbergh, Gerard F. M. J.;, Assignee: Janssen Pharmaceutica N.V. (BE) |
N-[.omega., (.omega.-1)-dialkyloxy]- and N-[.omega., (.omega.-1)-dialkenyloxy]-alk-1-yl-N, N, N-tetrasubstituted ammonium lipids and uses therefor
OF THE INVENTION Several advantages flow from the compounds and methods of the present invention. One of the advantages of the methods and materials disclosed herein is that they permit up to 100% en... Read More
Inventors: Eppstein, Deborah A.; Felgner, Philip L.; Gadek, Thomas R.; Jones, Gordon H.; Roman, Richard B.;, Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Vanadium complexes and derivatives thereof and methods related thereto
The present invention is directed to vanadium(V) complexes, including pharmaceutically acceptable salts thereof, of the formula: ##STR1## wherein, Z.sub.1 is independently selected from O and NR.sub.4... Read More
Inventors: Zhang, Zaihui; Toleikis, Philip M.; Lemieux, Pierre M.;, Assignee: Angiotech Pharmaceuticals, Inc. (Columbia, CA) |
Essential bacterial genes and their use
The invention is based on the discovery of 23 genes in the bacterium Streptococcus pneumoniae, and a related gene in the bacterium Bacillus subtilis, that are located within operons that are essential... Read More
Inventors: Youngman, Philip; Fritz, Christian; Murphy, Christopher; Guzman, Luz-Maria;, Assignee: Millennium Pharmaceuticals, Inc. (Cambridge, MA) |
Methods of using steroid-polyanionic polymer-based conjugated targeted to vascular endothelial cells
OF THE PREFERRED EMBODIMENTS Excessive or inappropriate endothelial cell, proliferation or activation can contribute to the cause or maintenance of several disease processes. This includes angiogenes... Read More
Inventors: Thorpe, Philip E.;, Assignee: Board of Regents the University of Texas System (Austin, TX) |
Microcapsule matrix microspheres, absorption-enhancing pharmaceutical compositions and methods
The present invention relates to microspheres, processes for the manufacture of said microspheres, pharmaceutical compositions comprising said microspheres, and sustained release methods of administer... Read More
Inventors: Vaghefi, Farid; Savitzky, Martin F.;, Assignee: Verion, Inc. (Lionville, PA) |
Interleukin 4 signal transducers
OF THE INVENTION The invention provides methods and compositions relating to IL-4 Stats --a novel family of transcription factors. An IL-4 Stat cDNA and amino acid sequence are disclosed in SEQUENCE ... Read More
Inventors: McKnight, Steven L.; Hou, Jinzhao;, Assignee: Tularik, Inc. (So. San Francisco, CA) |
Methods and compositions for identifying morphogen analogs
The present invention provides methods and compositions for identifying morphogen analogs. A morphogen analog of the present invention is a substance, preferably suitable for administration to a mamma... Read More
Inventors: Harada, Shun-ichi; Sampath, Kuber T.; Rodan, Gideon A.;, Assignee: Creative BioMolecule, Inc. (Hopkinton, MA) |
Gene Therapy 
